The Mendelian Society of Lund has been publishing the journal Hereditas since 1920.
Articles
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Citation: Hereditas 2023 160:24
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EZH2 regulates pancreatic cancer cells through E2F1, GLI1, CDK3, and Mcm4
Pancreatic cancer (PC) is one of the most common malignant tumors in digestive tract. To explore the role of epigenetic factor EZH2 in the malignant proliferation of PC, so as to provide effective medical help in...
Citation: Hereditas 2023 160:23 -
Whole-exome sequencing detected a novel AIFM1 variant in a Han-Chinese family with Cowchock syndrome
Charcot-Marie-Tooth disease(CMT) is a hereditary peripheral neuropathy, characterized by progressive distal hypoesthesia and amyotrophia. CMT is characterized by an X- linked recessive inheritance pattern. The...
Citation: Hereditas 2023 160:22 -
A potential immunotherapeutic and prognostic biomarker for multiple tumors including glioma: SHOX2
Short stature homeobox 2 (SHOX2) is significant gene in the development and progression of multiple types of tumors. Nonetheless, the biological role of SHOX2 within pan-cancer datasets has not been investigat...
Citation: Hereditas 2023 160:21 -
Genomics in animal breeding from the perspectives of matrices and molecules
This paper describes genomics from two perspectives that are in use in animal breeding and genetics: a statistical perspective concentrating on models for estimating breeding values, and a sequence perspective...
Citation: Hereditas 2023 160:20 -
Stable populations and Hardy-Weinberg equilibrium
The conditions on the mating matrix associated with a stable equilibrium are specified for an autosomal locus with five alleles. This points the way to the maintenance of Hardy-Weinberg proportions with non-ra...
Citation: Hereditas 2023 160:19 -
Deciphering the potential ability of RG108 in cisplatin-induced HEI-OC1 ototoxicity: a research based on RNA-seq and molecular biology experiment
Drug-induced hearing loss (DIHL) is very common, and seriously affects people's happiness in life. RG108 is a small molecule inhibitor. RG108 is protective against DIHL. Our purpose is to probe the incidence o...
Citation: Hereditas 2023 160:18 -
Identification and validation of autophagy-related genes in Kawasaki disease
Kawasaki disease (KD) is a systemic vasculitis of unknown etiology affecting mainly children. Studies have shown that the pathogenesis of KD may be related to autophagy. Using bioinformatics analysis, we asses...
Citation: Hereditas 2023 160:17 -
Mendel’s terminology and notation reveal his understanding of genetics
We describe both the terminology and use of symbols introduced by Mendel in his 1866 paper and discuss some misconceptions concerning their interpretation.
Citation: Hereditas 2023 160:16 -
γ-tocotrienol regulates gastric cancer by targeting notch signaling pathway
Gastric cancer is a common cause of death from cancer and an important global health care issue. Consequently, there is an urgent need to find new drugs and therapeutic targets for the treatment of gastric can...
Citation: Hereditas 2023 160:15 -
Comprehensive evaluations of individual discrimination, kinship analysis, genetic relationship exploration and biogeographic origin prediction in Chinese Dongxiang group by a 60-plex DIP panel
Dongxiang group, as an important minority, resides in Gansu province which is located at the northwest China, forensic detection system with more loci needed to be studied to improve the application efficiency...
Citation: Hereditas 2023 160:14 -
CCNE1 is a predictive and immunotherapeutic indicator in various cancers including UCEC: a pan-cancer analysis
CCNE1 plays an important oncogenic role in several tumors, especially high-stage serous ovarian cancer and endometrial cancer. Nevertheless, the fundamental function of CCNE1 has not been explored in multiple ...
Citation: Hereditas 2023 160:13 -
Circular RNA circHMCU promotes breast tumorigenesis through miR-4458/PGK1 regulatory cascade
Circular RNAs (circRNAs) are abnormally expressed in breast cancer (BC). However, the biological function and mechanism of circHMCU still need to be further explored.
Citation: Hereditas 2023 160:12 -
SMPD1 expression profile and mutation landscape help decipher genotype–phenotype association and precision diagnosis for acid sphingomyelinase deficiency
Acid sphingomyelinase deficiency (ASMD) disorder, also known as Niemann–Pick disease (NPD) is a rare genetic disease caused by mutations in SMPD1 gene, which encodes sphingomyelin phosphodiesterase (ASM). Except ...
Citation: Hereditas 2023 160:11 -
Development and validation of an RBP gene signature for prognosis prediction in colorectal cancer based on WGCNA
RNA binding proteins (RBPs) have been implicated in oncogenesis and progression in various cancers. However, the potential value of RBPs as prognostic indicators and therapeutic targets in colorectal cancer (C...
Citation: Hereditas 2023 160:10 -
Identification of the shared genes and immune signatures between systemic lupus erythematosus and idiopathic pulmonary fibrosis
Systemic lupus erythematosus (SLE) is an autoimmune disorder which could lead to inflammation and fibrosis in various organs. Pulmonary fibrosis is a severe complication in patients with SLE. Nonetheless, SLE-...
Citation: Hereditas 2023 160:9 -
Identification of autophagy-related genes in neuropathic pain through bioinformatic analysis
Neuropathic pain (NP) is one of the most common types of chronic pain and significantly compromises the quality of life. Autophagy is an intracellular catabolic process that is required to maintain cellular ho...
Citation: Hereditas 2023 160:8 -
Exploration of the underlying comorbidity mechanism in psoriasis and periodontitis: a bioinformatics analysis
Increasing evidence indicates that psoriasis (PSO) and periodontitis (PD) are likely to occur together, however, the underlying mechanism remains unclear.
Citation: Hereditas 2023 160:7 -
m6A-related lncRNA-based immune infiltration characteristic analysis and prognostic model for colonic adenocarcinoma
Colonic adenocarcinoma (COAD) is a common gastrointestinal tract tumor, and its occurrence and progression are typically associated with genomic instability, tumor-suppressor gene and oncogene mutations, and t...
Citation: Hereditas 2023 160:6 -
Understanding the contemporary high obesity rate from an evolutionary genetic perspective
The topic of obesity is gaining increasing popularity globally. From an evolutionary genetic perspective, it is believed that the main cause of the high obesity rate is the mismatch between environment and gen...
Citation: Hereditas 2023 160:5 -
Development of a risk model based on autophagy-related genes to predict survival and immunotherapy response in ovarian cancer
Autophagy is a highly conserved cellular proteolytic process that can interact with innate immune signaling pathways to affect the growth of tumor cells. However, the regulatory mechanism of autophagy in the t...
Citation: Hereditas 2023 160:4 -
Forkhead box P3 gene polymorphisms predispose to type 2 diabetes and diabetic nephropathy in the Han Chinese populations: a genetic-association and gender-based evaluation study
Functional mutations or polymorphisms affecting forkhead box P3 (FOXP3) can lead to their abnormal FOXP3 gene expression and/or defective Treg cells generation, thus resulting in autoimmune disease and inflammato...
Citation: Hereditas 2023 160:3 -
Identification of the prognostic value of Th1/Th2 ratio and a novel prognostic signature in basal-like breast cancer
Breast cancer is a heterogeneous group of diseases. The polarization of CD4+ T helper (Th) lymphocytes (mainly Th1 and Th2) may differ in breast cancers with different outcomes, but this has not been fully val...
Citation: Hereditas 2023 160:2 -
Upregulation of CENPM is associated with poor clinical outcome and suppression of immune profile in clear cell renal cell carcinoma
The response of advanced clear cell renal cell carcinoma (ccRCC) to immunotherapy is still not durable, suggesting that the immune landscape of ccRCC still needs to be refined, especially as some molecules tha...
Citation: Hereditas 2023 160:1 -
Stages of preadipocyte differentiation: biomarkers and pathways for extracellular structural remodeling
This study utilized bioinformatics to analyze the underlying biological mechanisms involved in adipogenic differentiation, synthesis of the extracellular matrix (ECM), and angiogenesis during preadipocyte diff...
Citation: Hereditas 2022 159:47 -
Variations in the TAS2R38 gene among college students in Hubei
The bitter taste receptor gene TAS2R38 is a member of the human TAS2R gene family. Polymorphisms in TAS2R38 affect the ability to taste the bitterness of phenylthiourea (PTC) compounds, thus affecting an individu...
Citation: Hereditas 2022 159:46 -
Identification of GINS1 as a therapeutic target in the cancer patients infected with COVID-19: a bioinformatics and system biology approach
Coronavirus disease 2019 (COVID-19) caused a series of biological changes in cancer patients which have rendered the original treatment ineffective and increased the difficulty of clinical treatment. However, ...
Citation: Hereditas 2022 159:45 -
Mechanisms of Cynarine for treatment of non-alcoholic fatty liver disease based on the integration of network pharmacology, molecular docking and cell experiment
Nonalcoholic Fatty Liver Disease (NAFLD) is a chronic Liver Disease prevalent all over the world. It has become more and more common in Japan, China and most western developed countries. The global prevalence ...
Citation: Hereditas 2022 159:44 -
Comprehensive analysis to identify pseudogenes/lncRNAs-hsa-miR-200b-3p-COL5A2 network as a prognostic biomarker in gastric cancer
Gastric cancer is one of the most common and deadly types of cancer. The molecular mechanism of gastric cancer progression remains unclear.
Citation: Hereditas 2022 159:43 -
Screening of ulcerative colitis biomarkers and potential pathways based on weighted gene co-expression network, machine learning and ceRNA hypothesis
Ulcerative colitis (UC) refers to an intractable intestinal inflammatory disease. Its increasing incidence rate imposes a huge burden on patients and society. The UC etiology has not been determined, so screen...
Citation: Hereditas 2022 159:42 -
Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation
ATM (ataxia-telangiectasia mutated) protein kinase is highly conserved in metazoan, and plays a critical role at DNA damage response, oxidative stress, metabolic stress, immunity, RNA biogenesis etc. Systemic ...
Citation: Hereditas 2022 159:41 -
A novel chromatin regulator-related immune checkpoint related gene prognostic signature and potential candidate drugs for endometrial cancer patients
Endometrial cancer (EC) is the most common gynecologic malignancy in developed countries and its prevalence is increasing. As an emerging therapy with a promising efficacy, immunotherapy has been extensively a...
Citation: Hereditas 2022 159:40 -
Integrative analyses of genes related to liver ischemia reperfusion injury
Liver ischemia reperfusion injury (LIRI) is not only a common injury during liver transplantation and major hepatic surgery, but also one of the primary factors that affect the outcome of postoperative disease...
Citation: Hereditas 2022 159:39 -
Bioinformatics analysis of diagnostic biomarkers for Alzheimer's disease in peripheral blood based on sex differences and support vector machine algorithm
The prevalence of Alzheimer's disease (AD) varies based on gender. Due to the lack of early stage biomarkers, most of them are diagnosed at the terminal stage. This study aimed to explore sex-specific signalin...
Citation: Hereditas 2022 159:38 -
CCR5 as a prognostic biomarker correlated with immune infiltrates in head and neck squamous cell carcinoma by bioinformatic study
C-C chemokine receptor 5 (CCR5) has recently been recognized as an underlying therapeutic target for various malignancies. However, the association of CCR5 with prognosis in the head and neck squamous cell car...
Citation: Hereditas 2022 159:37 -
Identification of tubulointerstitial genes and ceRNA networks involved in diabetic nephropathy via integrated bioinformatics approaches
Diabetic nephropathy (DN) is the major cause of end-stage renal disease worldwide. The mechanism of tubulointerstitial lesions in DN is not fully elucidated. This article aims to identify novel genes and clari...
Citation: Hereditas 2022 159:36 -
miR-31-5p from placental and peripheral blood exosomes is a potential biomarker to diagnose preeclampsia
Preeclampsia, a multisystem disorder of unknown etiology, is one of the leading causes of maternal and perinatal morbidity and mortality. Identifying sensitive, noninvasive markers can aid its prevention and i...
Citation: Hereditas 2022 159:35 -
An artificial neural network model based on autophagy-related genes in childhood systemic lupus erythematosus
Childhood systemic lupus erythematosus (cSLE) is a multisystemic, life-threatening autoimmune disease. Compared to adults, SLE in childhood is more active, can cause multisystem involvement including renal, ne...
Citation: Hereditas 2022 159:34 -
Association of novel MUC16, MAP3K15 and ABCA1 mutation with giant congenital melanocytic nevus
Giant congenital melanocytic nevus (GCMN) is the benign nevomelanocytic proliferation. Mutations in NRAS have been previously detected in GCMN, but mutations in BRAF are generally lacking in the Chinese popula...
Citation: Hereditas 2022 159:33 -
A novel molecular subtypes and risk model based on inflammatory response-related lncrnas for bladder cancer
Inflammation and long noncoding RNAs (lncRNAs) are gradually becoming important in the development of bladder cancer (BC). Nevertheless, the potential of inflammatory response-related lncRNAs (IRRlncRNAs) as a...
Citation: Hereditas 2022 159:32 -
Transformation and gene-disruption in the apple-pathogen, Neonectria ditissima
Apple production in Sweden and elsewhere is being threatened by the fungus, Neonectria ditissima, which causes a disease known as European canker. The disease can cause extensive damage and the removal of disease...
Citation: Hereditas 2022 159:31 -
Susceptibility genes of hyperuricemia and gout
Gout is a chronic metabolic disease that seriously affects human health. It is also a major challenge facing the world, which has brought a heavy burden to patients and society. Hyperuricemia (HUA) is the most...
Citation: Hereditas 2022 159:30 -
Arecoline promotes proliferation and migration of human HepG2 cells through activation of the PI3K/AKT/mTOR pathway
Arecoline is a well-known risk factor for oral submucosal fibrosis and cancer. However, the mechanistic correlation between arecoline and hepatocellular cancer remains elusive. Here, we investigated the effect...
Citation: Hereditas 2022 159:29 -
Mutation update of SERPING1 related to hereditary angioedema in the Chinese population
Hereditary angioedema (HAE) is a rare disease characterized by recurrent attacks of severe swellings of the skin and submucosa. More than 900 variants of the SERPING1 gene associated with HAE have been identified...
Citation: Hereditas 2022 159:28 -
ARG1 as a promising biomarker for sepsis diagnosis and prognosis: evidence from WGCNA and PPI network
Sepsis is a life-threatening multi-organ dysfunction caused by the dysregulated host response to infection. Sepsis remains a major global concern with high mortality and morbidity, while management of sepsis p...
Citation: Hereditas 2022 159:27 -
Identification of key apoptosis-related genes and immune infiltration in the pathogenesis of psoriasis
Psoriasis is a condition in which skin cells build up and form itchy scales and dry patches. It is also considered a common lifelong disease with an unclear pathogenesis. Furthermore, an effective cure for pso...
Citation: Hereditas 2022 159:26 -
HLA-A*03, the hemochromatosis ancestral haplotype, and phenotypes of referred hemochromatosis probands with HFE p.C282Y homozygosity
Human leukocyte antigen (HLA)-A*03, hemochromatosis ancestral haplotype marker, was associated with greater iron overload in hemochromatosis cohorts reported before discovery of the HFE gene. We sought to learn w...
Citation: Hereditas 2022 159:25 -
Identification of biomarkers, immune infiltration landscape, and treatment targets of ischemia–reperfusion acute kidney injury at an early stage by bioinformatics methods
Mechanisms underlying ischemia/reperfusion injury-acute kidney injury (IRI-AKI) are not fully elucidated. We conducted an integrative analysis of IRI-AKI by bioinformatics methods.
Citation: Hereditas 2022 159:24 -
Trimeric complexes of Antp-TBP with TFIIEβ or Exd modulate transcriptional activity
Hox proteins finely coordinate antero-posterior axis during embryonic development and through their action specific target genes are expressed at the right time and space to determine the embryo body plan. As ...
Citation: Hereditas 2022 159:23 -
Insights into AIM-InDel diversities in Yunnan Miao and Hani ethnic groups of China for forensic and population genetic purposes
Ancestry informative markers are regarded as useful tools for inferring the ancestral information of an individual, which have been widely used in the criminal investigations and population genetic studies. Pr...
Citation: Hereditas 2022 159:22
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