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  1. C-C chemokine receptor 5 (CCR5) has recently been recognized as an underlying therapeutic target for various malignancies. However, the association of CCR5 with prognosis in the head and neck squamous cell car...

    Authors: Chunhong Li, Shanlin Chen, Chuanyu Liu, Chune Mo, Weiwei Gong, Jiahua Hu, Min He, Lei Xie, Xianliang Hou, Jianhong Tang and Minglin Ou
    Citation: Hereditas 2022 159:37
    Content type: Research Published on:

  2. Diabetic nephropathy (DN) is the major cause of end-stage renal disease worldwide. The mechanism of tubulointerstitial lesions in DN is not fully elucidated. This article aims to identify novel genes and clari...

    Authors: Haiyan Cao, Xiaosheng Rao, Junya Jia, Tiekun Yan and Dong Li
    Citation: Hereditas 2022 159:36
    Content type: Research Published on:

  3. Preeclampsia, a multisystem disorder of unknown etiology, is one of the leading causes of maternal and perinatal morbidity and mortality. Identifying sensitive, noninvasive markers can aid its prevention and i...

    Authors: Gang Zou, Qingfang Ji, Zixiang Geng, Xiling Du, Lingyan Jiang and Te Liu
    Citation: Hereditas 2022 159:35
    Content type: Research Published on:

  6. Inflammation and long noncoding RNAs (lncRNAs) are gradually becoming important in the development of bladder cancer (BC). Nevertheless, the potential of inflammatory response-related lncRNAs (IRRlncRNAs) as a...

    Authors: Fucai Tang, Jiahao Zhang, Zechao Lu, Haiqin Liao, Chuxian Hu, Yuexue Mai, Yongchang Lai, Zeguang Lu, Zhicheng Tang, Zhibiao Li and Zhaohui He
    Citation: Hereditas 2022 159:32
    Content type: Research Published on:

  7. Apple production in Sweden and elsewhere is being threatened by the fungus, Neonectria ditissima, which causes a disease known as European canker. The disease can cause extensive damage and the removal of disease...

    Authors: Heriberto Vélëz, Jonas Skytte af Sätra, Firuz Odilbekov, Salim Bourras, Larisa Garkava-Gustavsson and Kerstin Dalman
    Citation: Hereditas 2022 159:31
    Content type: Brief report Published on:

  8. Gout is a chronic metabolic disease that seriously affects human health. It is also a major challenge facing the world, which has brought a heavy burden to patients and society. Hyperuricemia (HUA) is the most...

    Authors: Yue-Li Nian and Chong-Ge You
    Citation: Hereditas 2022 159:30
    Content type: Review Published on:

  9. Arecoline is a well-known risk factor for oral submucosal fibrosis and cancer. However, the mechanistic correlation between arecoline and hepatocellular cancer remains elusive. Here, we investigated the effect...

    Authors: Hai Xie, Ren Jing, Xiaoting Liao, Haishao Chen, Xianlong Xie, Huijun Dai and Linghui Pan
    Citation: Hereditas 2022 159:29
    Content type: Research Published on:

  11. Sepsis is a life-threatening multi-organ dysfunction caused by the dysregulated host response to infection. Sepsis remains a major global concern with high mortality and morbidity, while management of sepsis p...

    Authors: Jing-Xiang Zhang, Wei-Heng Xu, Xin-Hao Xing, Lin-Lin Chen, Qing-Jie Zhao and Yan Wang
    Citation: Hereditas 2022 159:27
    Content type: Research Published on:

  13. Human leukocyte antigen (HLA)-A*03, hemochromatosis ancestral haplotype marker, was associated with greater iron overload in hemochromatosis cohorts reported before discovery of the HFE gene. We sought to learn w...

    Authors: James C. Barton, J. Clayborn Barton and Ronald T. Acton
    Citation: Hereditas 2022 159:25
    Content type: Research Published on:

  14. Mechanisms underlying ischemia/reperfusion injury-acute kidney injury (IRI-AKI) are not fully elucidated. We conducted an integrative analysis of IRI-AKI by bioinformatics methods.

    Authors: Ruilian You, Zhige Heyang, Yixin Ma, Peng Xia, Hua Zheng, Jianfeng Lin, Peili Ji and Limeng Chen
    Citation: Hereditas 2022 159:24
    Content type: Research Published on:

  15. Hox proteins finely coordinate antero-posterior axis during embryonic development and through their action specific target genes are expressed at the right time and space to determine the embryo body plan. As ...

    Authors: Gustavo Jiménez-Mejía, Rubén Montalvo-Méndez, Carolina Hernández-Bautista, Claudia Altamirano-Torres, Martha Vázquez, Mario Zurita and Diana Reséndez-Pérez
    Citation: Hereditas 2022 159:23
    Content type: Research Published on:

  16. Ancestry informative markers are regarded as useful tools for inferring the ancestral information of an individual, which have been widely used in the criminal investigations and population genetic studies. Pr...

    Authors: Wei Cui, Shengjie Nie, Yating Fang, Man Chen, Ming Zhao, Qiong Lan, Chunmei Shen and Bofeng Zhu
    Citation: Hereditas 2022 159:22
    Content type: Research Published on:

  17. Ferroptosis, a novel manner of cell death depended on iron ion, contributed to goat mammary epithelial cell dysfunction. Interleukin-6 (IL-6) is a major pro-inflammatory factor during many inflammation-related...

    Authors: Guangqin Zhu, Shaopu Sui, Fengyun Shi and Qinglin Wang
    Citation: Hereditas 2022 159:21
    Content type: Research Published on:

  18. Spindle and kinetochore‑associated complex subunit 3 (SKA3) has recently been considered a key regulator of carcinogenesis. However, the connection between SKA3 and immune cell infiltration remains unknown.

    Authors: Chenyang Wang, Shasha Liu, Xinhong Zhang, Yan Wang, Peng Guan, Fanyou Bu, Hao Wang, Dawen Wang, Yi Fan, Sichuan Hou and Zhilei Qiu
    Citation: Hereditas 2022 159:20
    Content type: Research Published on:

  19. The historian studies revealed during Mendel’s later research period when mainly focusing on the constant hybrid in Hieracium, he had to be intervened to conduct the controlled pollination experiments in Mirabili...

    Authors: Hui Zhang, Xiaoxi Zhao, Fan Zhao, Jianshan Han and Kun Sun
    Citation: Hereditas 2022 159:19
    Content type: Letter to the Editor Published on:

  22. Lysophosphatidic acid (LPA) and its receptors play a key role in regulating cancer progression. Upregulation of LPA receptor 2 (LPAR2) plays a role in carcinogenesis; however, the exact role of LPAR2 in tumors re...

    Authors: Kai Sun, Ri-xin Chen, Jing-zhang Li and Zhan-xiong Luo
    Citation: Hereditas 2022 159:16
    Content type: Research Published on:

  23. The efficacy of moxibustion in treating rheumatoid arthritis is recognized, but its molecular mechanism is still unclear. This study aimed to characterize the molecular map and potential key genes in the proce...

    Authors: Li Zeng, Jing Guo, Ping Du, Shuguang Yu and Haiyan Yin
    Citation: Hereditas 2022 159:15
    Content type: Research Published on:

  24. Sepsis is a life-threatening condition in which the immune response is directed towards the host tissues, causing organ failure. Since sepsis does not present with specific symptoms, its diagnosis is often del...

    Authors: Mingliang Li, He Huang, Chunlian Ke, Lei Tan, Jiezhong Wu, Shilei Xu and Xusheng Tu
    Citation: Hereditas 2022 159:14
    Content type: Research Published on:

  28. A chronic progressive degenerative joint disease, such as osteoarthritis (OA) is positively related to age. The medical economy is facing a major burden, because of the high disability rate seen in patients wi...

    Authors: Yaguang Han, Jun Wu, Zhenyu Gong, Yiqin Zhou, Haobo Li, Yi Chen and Qirong Qian
    Citation: Hereditas 2022 159:10
    Content type: Research Published on:

  29. The goal of this study was to evaluate marker-assisted selection (MAS) in broiler chickens using previously mapped gene regions associated with ascites syndrome incidence. The second-generation MAS products we...

    Authors: Katie Pepper Lee, Nicholas B. Anthony, Sara K. Orlowski and Douglas D. Rhoads
    Citation: Hereditas 2022 159:9
    Content type: Research Published on:

  30. Niemann-Pick disease type C (NPC) is a rare lysosomal neurovisceral storage disease caused by mutations in the NPC 1 (95%) or NPC2 (5%) genes. The products of NPC1 and NPC2 genes play considerable roles in glycol...

    Authors: Rezvan Abtahi, Parvaneh Karimzadeh, Omid Aryani, Diba Akbarzadeh, Shadab Salehpour, Alireza Rezayi, Seyed Hassan Tonekaboni, Reza Zolfaghari Emameh and Massoud Houshmand
    Citation: Hereditas 2022 159:8
    Content type: Research Published on:

  32. This study aimed to explore the mRNA and protein expression of SLC3A2 in laryngeal carcinoma cells and tissues, and functional regulatory mechanism of SLC3A2 in cell ferroptosis of laryngeal carcinoma.

    Authors: Fangxing Wu, Gaoyun Xiong, Zejun Chen, Chenyang Lei, Qianqian Liu and Yundan Bai
    Citation: Hereditas 2022 159:6
    Content type: Research Published on:

  33. To explore the role and effects of the single-nucleotide polymorphisms (SNPs) of the two functionally related indoleamine 2,3-dioxygenase (IDO) isoforms on IDO activity in the Chinese Han ethnic population.

    Authors: Tingming Cao, Guangming Dai, Hongqian Chu, Chengcheng Kong, Huijuan Duan, Na Tian and Zhaogang Sun
    Citation: Hereditas 2022 159:5
    Content type: Research Published on:

  34. Maffucci syndrome (MS, OMIM 166000) is an extremely unusual, nonhereditary, multisystemic disorder that is characterized with multiple enchondromas and vascular lesions, most of which are spindle cell hemangio...

    Authors: Yi Sun, Xindong Fan, Yamin Rao, Zhenfeng Wang, Deming Wang, Xitao Yang, Lianzhou Zheng, Mingzhe Wen, Ren Cai and Lixin Su
    Citation: Hereditas 2022 159:4
    Content type: Brief report Published on:

  35. MicroRNAs (miRNAs) are involved in the prognosis of nasopharyngeal carcinoma (NPC). This study used clinical data and expression data of miRNAs to develop a prognostic survival signature for NPC patients to de...

    Authors: Bo Tu, Ling Ye, Qingsong Cao, Sisi Gong, Miaohua Jiang and Hui Li
    Citation: Hereditas 2022 159:3
    Content type: Research Published on:

  36. The homeobox gene homeobrain (hbn) is located in the 57B region together with two other homeobox genes, Drosophila Retinal homeobox (DRx) and orthopedia (otp). All three genes encode transcription factors with im...

    Authors: Kirsten Hildebrandt, Dieter Kolb, Christine Klöppel, Petra Kaspar, Fabienne Wittling, Olga Hartwig, Jannic Federspiel, India Findji and Uwe Walldorf
    Citation: Hereditas 2022 159:2
    Content type: Research Published on:

  37. PIK3CA-related overgrowth spectrum (PROS) is a series of congenital, sporadic disorders that are associated with segmental overgrowth phenotypes and postzygotic, somatic gene mutations in the PIK3CA-ATK-mTOR pat...

    Authors: Li Xin Su, Yi Sun, Zhenfeng Wang, Deming Wang, Xitao Yang, Lianzhou Zheng, Mingzhe Wen, Xindong Fan and Ren Cai
    Citation: Hereditas 2022 159:1
    Content type: Brief report Published on:

  38. Indian Hedgehog (IHH), an important cell signaling protein, plays a key regulatory role in development of cartilage and chondrogenesis. Earlier studies have shown that heterozygous missense mutations in IHH gene ...

    Authors: Wei Zhou, Luan Chen, Hao Wu, Ting Wang, Gang Ma, Baocheng Wang, Cong Wang, Na Zhang, Yingtian Zhang, Lin He, Shengying Qin, Xiaofang Sun, Hai Zhang and Lu Shen
    Citation: Hereditas 2021 158:48
    Content type: Research Published on:

  39. Asthma is a common chronic respiratory disease that influences 300 million people all over the world. However, the pathogenesis of asthma has not been fully elucidated. It has been reported that transforming g...

    Authors: Yuebin Wang, Huike Yang, Xian Su, Anqiang Cao, Feng Chen, Peng Chen, Fangtao Yan and Huirong Hu
    Citation: Hereditas 2021 158:47
    Content type: Research Published on:

  41. Developmental stuttering is the most common form of stuttering without apparent neurogenic or psychogenic impairment. Recently, whole-exome sequencing (WES) has been suggested to be a promising approach to stu...

    Authors: Yimin Sun, Yong Gao, Yuxi Zhou, Yulong Zhou, Ying Zhang, Dong Wang and Li-Hai Tan
    Citation: Hereditas 2021 158:46
    Content type: Research Published on:

  43. Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide due to its high degree of malignancy, high incidence, and low survival rate. However, the underlying mechanisms of ...

    Authors: Yi Shi, Ji-Bin Liu, Jing Deng, Da-Zhi Zou, Jian-Jun Wu, Ya-Hong Cao, Jie Yin, Yu-Shui Ma, Fu Da and Wen Li
    Citation: Hereditas 2021 158:44
    Content type: Review Published on:

  44. Immortalized cell lines have long been used as model systems to systematically investigate biological processes under controlled and reproducible conditions, providing insights that have greatly advanced cellu...

    Authors: Yulong Liu, Hua Li, Daniel M. Czajkowsky and Zhifeng Shao
    Citation: Hereditas 2021 158:43
    Content type: Brief report Published on:

  45. The Drosophila brain is an ideal model system to study stem cells, here called neuroblasts, and the generation of neural lineages. Many transcriptional activators are involved in formation of the brain during the...

    Authors: Christine Klöppel, Kirsten Hildebrandt, Dieter Kolb, Nora Fürst, Isabelle Bley, Ruth-Jessica Karlowatz and Uwe Walldorf
    Citation: Hereditas 2021 158:42
    Content type: Research Published on:

  46. Many transcription factors are involved in the formation of the brain during the development of Drosophila melanogaster. The transcription factor Earmuff (Erm), a member of the forebrain embryonic zinc finger fam...

    Authors: Kirsten Hildebrandt, Sabrina Kübel, Marie Minet, Nora Fürst, Christine Klöppel, Eva Steinmetz and Uwe Walldorf
    Citation: Hereditas 2021 158:41
    Content type: Research Published on:

  47. Autosomal dominant osteopetrosis type II (ADO2) is a genetically and phenotypically metabolic bone disease, caused by osteoclast abnormalities. The pathways dysregulated in ADO2 could lead to the defects in os...

    Authors: Chunhong Li, Yu Shangguan, Peng Zhu, Weier Dai, Donge Tang, Minglin Ou and Yong Dai
    Citation: Hereditas 2021 158:40
    Content type: Research Published on:

  48. Oral lichen planus (OLP) is a T cell-mediated autoimmune disease recognized as an oral potential malignant disorder (OPMD) with the precise mechanism unknown. This study focused on the transcriptional profiles...

    Authors: Haoyu Wang, Yiwen Deng, Siqi Peng, Li Yan, Hui Xu, Qingzhong Wang and Zhengyu Shen
    Citation: Hereditas 2021 158:39
    Content type: Research Published on:

  49. Alterations in genes encoding chromatin regulatory proteins are prevalent in cancers and may confer oncogenic properties and molecular changes linked to therapy resistance. However, the impact of copy number a...

    Authors: Zhiwei Xing, Buhuan Ma, Weiting Sun, Yimin Sun and Caixia Liu
    Citation: Hereditas 2021 158:38
    Content type: Research Published on:

  50. Osteoarthritis (OA) and rheumatoid arthritis (RA) were two major joint diseases with similar clinical phenotypes. This study aimed to determine the mechanistic similarities and differences between OA and RA by...

    Authors: Yanzhi Ge, Zuxiang Chen, Yanbin Fu, Xiujuan Xiao, Haipeng Xu, Letian Shan, Peijian Tong and Li Zhou
    Citation: Hereditas 2021 158:37
    Content type: Research Published on:
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