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The evolution of transcriptional repressors in the Notch signaling pathway: a computational analysis

The Notch signaling pathway is highly conserved in eukaryotes. Notch repressors, however, are only known from arthropods and vertebrates (Drosophila: Hairless, vertebrates: SHARP/MINT and KyoT2). Database searches revealed homologues of Hairless only after the Chelicerata-Mandibulata radiation, SHARP only in vertebrates, and KyoT2 with a ΦWΦP interacting motif only in placental mammals. However, the data provide a hypothesis on the evolution of KyoT2 from Prickle-like ancestors. These Prickle-like ancestors contain a novel, putative CSL interacting motif. If it were confirmed by experiments, this work has uncovered a novel, very ancestral CSL interactor found in the entire animal kingdom.

Aims and scope

For almost a century, Hereditas has published original cutting-edge research and reviews. As the Official journal of the Mendelian Society of Lund, the journal welcomes research from across all areas of genetics and genomics. Topics of interest include human and medical genetics, animal and plant genetics, microbial genetics, agriculture and bioinformatics. Articles covering novel viral sequences or the use of new technology and software in genomic research are also welcomed.


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Hereditas launched with BioMed Central in 2015, transferring from its previous publisher Wiley. All back content is available in the archive.


Stefan Baumgartner, Lund University
Yongyong Shi, Shanghai Jiao Tong University

Society information

The Mendelian Society of Lund was founded in 1910 and except for a short break during 1912-1916 has been active ever since. In 1920, the Society started to publish Hereditas, a scientific journal in genetics. In the post-genomic era, the scope of Hereditas has evolved to include any research on genomic analysis.

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