From: A novel mutation in the FGG gene causes hypofibrinogenemia in a Chinese family
Test | I:2 | II:1 | II:2 | II:4 | III:1 | III:2 | III:3 | Reference interval | |
---|---|---|---|---|---|---|---|---|---|
Coagulation testing results | PT | 11.8 | 12.9 ↑ | 11.3 | 11.4 | 12.6 ↑ | 11.8 | 14.9 ↑ | 9.4–12.5s |
APTT | 27.7 | 33.9 | 32.1 | 29.5 | 39.2 ↑ | 36.5 | 30.8 | 25.1–36.5s | |
TT | 15.3 | 18.6 ↑ | 15.3 | 18.8 ↑ | 19.4 ↑ | 13 | 22.5 ↑ | 10.3–16.6s | |
PT-derived | 4.65 | 1.51 ↓ | 3.61 | 1.67 ↓ | 0.8 ↓ | / | 0.97 ↓ | 2.38–4.98 g/L | |
Fg:C | 3.3 | 1.3 ↓ | 2.96 | 1.45 ↓ | 0.72 ↓ | 2.57 | 0.85 ↓ | 2.38–4.98 g/L | |
Fg:Ag | 2.93 | 1.35 ↓ | 3.59 ↑ | 1.51 ↓ | 0.779 ↓ | 2.53 | 0.769 ↓ | 1.8–3.5 g/L | |
D-Dimer | 0.65 ↑ | 0.13 | 0.17 | 0.22 | 0.1 | 0.17 | 0.05 | 0–0.5 µg/mL | |
Thromboelast-ography results | R | / | 1.8 | / | 6.1 | 7.9 | 5.8 | 2.8 ↓ | 4–9 min |
K | / | 8.4 ↑ | / | 8.2 ↑ | 10.9 ↑ | 2.4 | 13.7 ↑ | 1–3 min | |
Angle | / | 33.8 ↓ | / | 30.2 ↓ | 25.1 ↓ | 56 | 26.4 ↓ | 53–72 deg | |
MA | / | 35.2 ↓ | / | 37 ↓ | 27.8 ↓ | 54 | 27.3 ↓ | 50–70 mm | |
Inflammatory markers | WBC | 4.65 | 9.25 | 5.69 | 6.38 | 6.06 | 4.54 | 8.72 | 3.5–9.5 g/L |
CRP | 1.04 | 5.92 | 2.38 | 1.14 | 1.6 | 1.17 | 2.31 | 0–10 mg/L | |
SAA | < 4.80 | 5.38 | < 4.80 | < 4.80 | < 4.80 | 5.56 | < 4.80 | 0–10 mg/L | |
PCT | < 0.05 | < 0.05 | < 0.05 | < 0.05 | < 0.05 | < 0.05 | < 0.05 | 0–0.05 mg/mL | |
Liver function | AST | 21 | 34 | 30 | 21 | 19 | 14 | 18 | 13–35 U/L |
ALT | 9 | 34 | 30 | 12 | 21 | 13 | 16 | 7–40 U/L | |
TP | 73.6 | 69 | 73.6 | 71.9 | 75 | 68.8 | 70.8 | 65–85 g/L | |
ALB | 45.3 | 45.8 | 44.1 | 46.2 | 51 | 46 | 46.5 | 35–55 g/L |