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Table 1 Coagulation testing results, thromboelastography results, blood test results and liver function results

From: A novel mutation in the FGG gene causes hypofibrinogenemia in a Chinese family

 

Test

I:2

II:1

II:2

II:4

III:1

III:2

III:3

Reference interval

Coagulation testing results

PT

11.8

12.9 ↑

11.3

11.4

12.6 ↑

11.8

14.9 ↑

9.4–12.5s

APTT

27.7

33.9

32.1

29.5

39.2 ↑

36.5

30.8

25.1–36.5s

TT

15.3

18.6 ↑

15.3

18.8 ↑

19.4 ↑

13

22.5 ↑

10.3–16.6s

PT-derived

4.65

1.51 ↓

3.61

1.67 ↓

0.8 ↓

/

0.97 ↓

2.38–4.98 g/L

Fg:C

3.3

1.3 ↓

2.96

1.45 ↓

0.72 ↓

2.57

0.85 ↓

2.38–4.98 g/L

Fg:Ag

2.93

1.35 ↓

3.59 ↑

1.51 ↓

0.779 ↓

2.53

0.769 ↓

1.8–3.5 g/L

D-Dimer

0.65 ↑

0.13

0.17

0.22

0.1

0.17

0.05

0–0.5 µg/mL

Thromboelast-ography

results

R

/

1.8

/

6.1

7.9

5.8

2.8 ↓

4–9 min

K

/

8.4 ↑

/

8.2 ↑

10.9 ↑

2.4

13.7 ↑

1–3 min

Angle

/

33.8 ↓

/

30.2 ↓

25.1 ↓

56

26.4 ↓

53–72 deg

MA

/

35.2 ↓

/

37 ↓

27.8 ↓

54

27.3 ↓

50–70 mm

Inflammatory markers

WBC

4.65

9.25

5.69

6.38

6.06

4.54

8.72

3.5–9.5 g/L

CRP

1.04

5.92

2.38

1.14

1.6

1.17

2.31

0–10 mg/L

SAA

< 4.80

5.38

< 4.80

< 4.80

< 4.80

5.56

< 4.80

0–10 mg/L

PCT

< 0.05

< 0.05

< 0.05

< 0.05

< 0.05

< 0.05

< 0.05

0–0.05 mg/mL

Liver function

AST

21

34

30

21

19

14

18

13–35 U/L

ALT

9

34

30

12

21

13

16

7–40 U/L

TP

73.6

69

73.6

71.9

75

68.8

70.8

65–85 g/L

ALB

45.3

45.8

44.1

46.2

51

46

46.5

35–55 g/L

  1. Abbreviations PT, prothrombin time; APTT, activated partial thromboplastin time; TT, thrombin time; Fg:C, activity of fibrinogen measured by Clauss assay; Fg:Ag, antigen level of fibrinogen; WBC, white blood cell; CRP, C-reactive protein; SAA, serum amyloid A; PCT, procalcitonin; AST, aspartate aminotransferase; ALT, alanine aminotransferase; TP, total protein; ALB, albumin. ↑, above; ↓, below