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Table 5 GSEA enrichment summary

From: Comprehensive analysis revealed the immunoinflammatory targets of rheumatoid arthritis based on intestinal flora, miRNA, transcription factors, and RNA-binding proteins databases, GSEA and GSVA pathway observations, and immunoinfiltration typing

GEO accession

ID

Description

enrichmentScore

pvalue

qvalues

GSE55235

hsa05310

Asthma

0.876

 < 0.001

 < 0.001

hsa05330

Allograft rejection

0.842

 < 0.001

 < 0.001

hsa05340

Primary immunodeficiency

0.841

 < 0.001

 < 0.001

hsa05320

Autoimmune thyroid disease

0.837

 < 0.001

 < 0.001

hsa04672

Intestinal immune network for IgA production

0.826

 < 0.001

 < 0.001

hsa05150

Staphylococcus aureus infection

0.793

 < 0.001

 < 0.001

hsa04940

Type I diabetes mellitus

0.773

 < 0.001

 < 0.001

hsa05332

Graft-versus-host disease

0.773

 < 0.001

 < 0.001

hsa04612

Antigen processing and presentation

0.739

 < 0.001

 < 0.001

hsa05322

Systemic lupus erythematosus

0.736

 < 0.001

 < 0.001

hsa03008

Ribosome biogenesis in eukaryotes

-0.591

0.004

0.017

hsa05217

Basal cell carcinoma

-0.606

0.002

0.01

hsa04137

Mitophagy—animal

-0.607

 < 0.001

0.006

hsa04978

Mineral absorption

-0.617

0.003

0.013

hsa00830

Retinol metabolism

-0.635

0.004

0.015

hsa05213

Endometrial cancer

-0.64

 < 0.001

0.003

hsa03040

Spliceosome

-0.649

 < 0.001

 < 0.001

hsa04710

Circadian rhythm

-0.685

0.006

0.022

hsa05216

Thyroid cancer

-0.693

 < 0.001

0.006

hsa00350

Tyrosine metabolism

-0.769

 < 0.001

 < 0.001

GSE55457

hsa05340

Primary immunodeficiency

0.785

 < 0.001

 < 0.001

hsa05330

Allograft rejection

0.724

 < 0.001

 < 0.001

hsa05320

Autoimmune thyroid disease

0.683

 < 0.001

 < 0.001

hsa04940

Type I diabetes mellitus

0.672

 < 0.001

 < 0.001

hsa05332

Graft-versus-host disease

0.661

 < 0.001

0.002

hsa04672

Intestinal immune network for IgA production

0.657

 < 0.001

 < 0.001

hsa04061

Viral protein interaction with cytokine and cytokine receptor

0.643

 < 0.001

 < 0.001

hsa04062

Chemokine signaling pathway

0.566

 < 0.001

 < 0.001

hsa04612

Antigen processing and presentation

0.563

 < 0.001

0.001

hsa04650

Natural killer cell mediated cytotoxicity

0.562

 < 0.001

 < 0.001

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

-0.432

0.007

0.034

hsa04928

Parathyroid hormone synthesis, secretion and action

-0.444

 < 0.001

0.006

hsa05410

Hypertrophic cardiomyopathy

-0.455

0.001

0.008

hsa04520

Adherens junction

-0.477

0.001

0.01

hsa05031

Amphetamine addiction

-0.479

0.004

0.023

hsa04923

Regulation of lipolysis in adipocytes

-0.481

0.004

0.024

hsa05210

Colorectal cancer

-0.488

 < 0.001

0.002

hsa04350

TGF-beta signaling pathway

-0.506

 < 0.001

0.001

hsa04979

Cholesterol metabolism

-0.541

 < 0.001

0.006

hsa04977

Vitamin digestion and absorption

-0.666

0.005

0.028