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Fig. 5 | Hereditas

Fig. 5

From: A novel missense mutation (FGG c.1168G > T) in the gamma chain of fibrinogen causing congenital hypodysfibrinogenemia with bleeding phenotype

Fig. 5

a, b Predicted tertiary structure and surface structure of the WT γ-chain, respectively. The yellow area indicated the hole “a”. Red referred to the γD390. c, d The HB between the γ390 and other residues in WT and γD390Y fibrinogen γ-chain. The green and blue sticks referred to different amino acids. The yellow dotted lines meant HB between residues. Hole “a” is a constitutive complementary-binding pocket in the γD region that would interact with the polymerization site termed knob “A”. HB, hydrogen bond

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Hereditas

ISSN: 1601-5223

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