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Table 2 Forty key targets of ACP acting on colon cancer and related parameters

From: Mechanisms of Actinidia chinensis Planch in treating colon cancer based on the integration of network pharmacology, molecular docking, and experimental verification

Gene

Uniprot ID

Degree centrality

Betweenness centrality

Closeness centrality

TP53

P04637

48

0.333

0.514

HSP90AA1

P07900

38

0.261

0.490

MYC

P01106

27

0.086

0.447

CASP3

P42574

25

0.053

0.433

CDK1

P06493

21

0.015

0.412

PIK3R1

P27986

21

0.037

0.387

CCND1

P24385

20

0.026

0.420

FYN

P06241

19

0.041

0.377

HSP90AB1

P08238

18

0.025

0.412

CCNA2

P20248

17

0.006

0.375

MMP9

P14780

17

0.078

0.395

HPGDS

O60760

16

0.140

0.436

CCNB1

P14635

16

0.003

0.373

CHEK1

O14757

16

0.007

0.393

STAT1

P42224

16

0.031

0.416

LCK

P06239

15

0.030

0.372

IL1B

P01584

15

0.017

0.370

FGF2

P09038

15

0.053

0.391

PLK1

P53350

14

0.007

0.398

BIRC5

Q9NQS7

14

0.005

0.371

PCNA

P12004

14

0.009

0.358

CDK2

P24941

14

0.006

0.399

AURKB

Q96GD4

13

0.030

0.391

GSK3B

P49841

13

0.007

0.412

CAV1

Q03135

13

0.029

0.377

TOP2A

P11388

12

0.006

0.356

CXCL12

P48061

12

0.013

0.353

CYP2E1

P05181

11

0.087

0.372

MAPT

P10636

11

0.018

0.397

CCL2

P13500

11

0.005

0.328

CXCL8

P10145

11

0.004

0.336

EPHA2

P29317

10

0.035

0.372

PPARG

P37231

10

0.028

0.414

SLC2A1

P11166

9

0.072

0.380

NR3C1

P04150

9

0.018

0.393

CASP8

Q14790

8

0.004

0.379

BCL2

P10415

8

0.013

0.357

HSPB1

P04792

8

0.004

0.385

CHEK2

O96017

8

0.005

0.349

PGR

P06401

8

0.005

0.395