Variant | PROVEAN score | Prediction (cutoff = -2.5) | SNAP2 score | PANTHER | I-Mutant stability prediction | ΔΔG (Kcal/mol) | RIa | MUpro ΔΔG (Kcal/mol) | mCSM-NA ΔΔG (Kcal/mol) |
---|---|---|---|---|---|---|---|---|---|
R186W | -7.46 | Deleterious | 99 | damaging | decrease | -0.55 | 6 | -0.717 | -0.853 |
R186Q | -3.7 | Deleterious | 89 | damaging | decrease | -1.09 | 8 | -0.669 | -1.255 |