Table 1 Potential drugs identified by CMap database
Name | Score | Target | MOA (mechanism of action) |
|---|---|---|---|
isoliquiritigenin | -96.41 | AKR1B1, HRH2, SIRT1 | Guanylate cyclase activator |
beta-CCP | -95.98 | GABRA1, GABRG2, IDO1 | Indoleamine 2,3-dioxygenase inhibitor |
piperacillin | -91.66 | Â | Bacterial cell wall synthesis inhibitor |
memantine | -87.22 | GRIN1, CHRFAM7A, CYP2E1, DRD2, GRIN2A, GRIN2B, GRIN3A, HTR3A | Glutamate receptor antagonist |
noscapine | -86.38 | BDKRB2, SIGMAR1 | Bradykinin receptor antagonist, Tubulin inhibitor |
huperzine-a | -86.28 | ACHE | Acetylcholinesterase inhibitor |
orantinib | -85.89 | PDGFRB, AURKA, AURKB, KDR, EGFR, FGFR1, FGFR2, PDGFRA, TBK1 | FGFR inhibitor, VEGFR inhibitor, PDGFR receptor inhibitor |
androstenol | -85.18 | NR1I3 | GABA receptor modulator |
taurodeoxycholic-acid | -84.95 | Â | Bile acid |
eicosatetraynoic-acid | -83.34 | ALOX12, PPARA, PPARG, PTGS1 | Cyclooxygenase inhibitor, Lipoxygenase inhibitor |
clofazimine | -82.31 | Â | GK0582 inhibitor |
norepinephrine | -82 | ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB3, ADRB2, DRD1, DRD5, PAH, SLC18A1, SLC18A2 | Adrenergic receptor agonist |
vinburnine | -80.09 | CHRM1, CHRM2, CHRM3, CHRM4 | Adrenergic receptor antagonist |