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Table 3 Gender-based data on genotype and allele frequency distribution of rs3761548C/A and rs2294021 Polymorphism among HC, T2DM and T2DN

From: Forkhead box P3 gene polymorphisms predispose to type 2 diabetes and diabetic nephropathy in the Han Chinese populations: a genetic-association and gender-based evaluation study

   

Genotype

 

χ2

(p-value)

 

Alleles

OR 95%CI

p-value

Group comparison

OR 95%CI

p-value

rs3761548

 

CC (%)

CA (%)

AA (%)

 

C

A

     

Females

HC (103)

70 (68)

29 (28)

4 (4)

5.294 (0.071)

0.82

0.18

0.593 (0.381–0.924)

0.021

CC vs. Others

0.636 (0.374–1.083)

0.096

Patients (141)

81 (58)

44 (31)

13 (23)

0.73

0.27

CA vs Others

1.157 (0.663–2.022)

0.607

AA vs. Others

3.168 (1.027–9.777)

0.045

T2DM (85)

46 (54)

36 (42)

3 (4)

9.503 (0.009)

0.75

0.25

0.857 (0.499–1.473)

0.577

CC vs. Others

1.216 (0.615–2.406)

0.574

T2DN (56)

33 (59)

15 (27)

8 (14)

0.72

0.28

CA vs Others

0.371 (0.172–0.802)

0.012

AA vs. Others

4.556 (1.153–17.997)

0.031

Males

HC (97)

89 (92)

3 (3)

5 (5)

15.923 (< 0.001)

0.93

0.07

0.214 (0.118–0.389)

< 0.001

CC vs. Others

0.238 (0.110–0.516)

< 0.001

Patients (259)

188 (73)

12 (4)

59 (23)

0.75

0.25

CA vs Others

1.522 (0.420–5.515)

0.522

AA vs. Others

5.428 (2.108–13.975)

< 0.001

T2DM (115)

98 (85)

2 (2)

15 (13)

15.944 (< 0.001162)

0.86

0.14

0.299 (0.192–0.467)

< 0.001

CC vs. Others

0.307 (0.166–0.569)

< 0.001176

T2DN (144)

92 (64)

3 (2)

49 (34)

0.65

0.35

CA vs Others

1.202 (0.197–7.318)

0.842

AA vs. Others

3.439 (1.808–6.540)

< 0.001166

rs2294021

 

CC (%)

CT (%)

TT (%)

 

C

T

     

Females

HC (103)

Patients (141)

30 (29)

54 (38)

51 (50)

49 (35)

22 (21)

38 (27)

5.376 (0.068)

0.54

0.56

0.46

0.44

075 (0.749–1.542)

0.695

CC vs. Others

1.510 (0.877–2.602)

0.137

CT vs Others

0.543 (0.323–0.913)

0.021

TT vs. Others

1.358 (0.745–2.476)

0.317

T2DM (85)

T2DN (56)

36 (42)

27 (32)

22 (26)

1.559 (0.459)

0.58

0.42

0.770 (0.477–1.245)

0.770

CC vs. Others

0.645 (0.318–1.307)

0.224

18 (32)

22 (39)

16 (29)

0.70

0.30

CT vs Others

1.390 (0.687–2.811)

0.360

TT vs. Others

1.145 (0.538–2.440)

0.725

Males

HC (97)

Patients (259)

52 (54)

112 (48)

4 (4)

19 (3)

41 (42)

128 (49)

3.533 (0.171)

0.58

0.42

0.647 (0.464–0.903)

0.010

CC vs. Others

0.659 (0.413–1.054)

0.082

0.47

0.53

CT vs Others

1.841 (0.610–5.554)

0.279

TT vs. Others

1.335 (0.833–2.137)

0.230

T2DM (115)

T2DN (144)

53 (46)

59 (41)

17 (15)

2 (1.4)

45 (39)

83 (57.6)

20.454 (< 0.001036)

0.86

0.14

0.621 (0.438–0.881)

0.008

CC vs. Others

0.812 (0.495–1.332)

0.409

0.66

0.34

CT vs Others

0.081 (0.018–0.359)

0.001

TT vs. Others

2.117 (1.284–3.488)

0.003

  1. OR Odds Ratio and 95% CI, HC Healthy controls, T2DM Type 2 diabetes, T2DN Type 2 diabetic Nephropathy; patients = Female/Male (T2DN + T2DM)
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Hereditas

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