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Table 3 Correlation analysis between CCR5 and related genes and markers of monocyte, macrophages, and T-cell exhaustion in Gene Expression Profiling Interaction Analysis (GEPIA)

From: CCR5 as a prognostic biomarker correlated with immune infiltrates in head and neck squamous cell carcinoma by bioinformatic study

Description

Gene markers

HNSC

Tumor

Normal

Cor

p

Cor

p

Monocyte

CD86

0.77

4.7e-101***

0.67

7.6e-07***

CD115 (CSF1R)

0.84

1.3e-136***

0.69

2.4e-07***

TAM

CCL2

0.58

4.9e-48***

0.12

0.45

CD68

0.43

4.9e-25***

0.35

0.02

IL10

0.63

2.8e-59***

0.56

7.9e-05***

M1 Macrophage

INOS (NOS2)

0.31

6.3e-13***

0.38

0.011

IRF5

0.33

1.5e-14***

0.29

0.052

COX2(PTGS2)

−0.14

0.0017*

0.08

0.6

M2 Macrophage

CD163

0.67

5.5e-70***

0.19

0.23

VSIG4

0.63

3.9e-59***

0.2

0.18

MS4A4A

0.74

1.7e-89***

0.22

0.15

T cell exhaustion

PD-1 (PDCD1)

0.9

7.1e-184***

0.76

2.2e-09***

PDL1(PDCD1LG2)

0.59

7.6e-50***

0.51

0.00038***

CTLA4

0.83

1.8e-133***

0.64

2.9e-06***

LAG3

0.79

8.7e-113***

0.67

5.4e-07***

TIM-3 (HAVCR2)

0.88

9.9e-167***

0.72

2.9e-08***

GZMB

0.75

1.6e-94***

0.56

7.5e-05***

  1. Note. HNSC Head and neck squamous cell carcinoma, TAM Tumor-associated macrophages; Tumor correlation analysis in tumor tissue of TCGA; Normal correlation analysis in normal tissue of TCGA. *p < 0.01; **p < 0.001; ***p < 0