Table 2 Correlation analysis between CCR5 and related genes and markers of immune cells in Tumor Immune Estimation Resource (TIMER2.0)

CD8+ T cell

CD8A

0.896

9.19e-186***

0.887

1.58e-166***

CD8B

0.846

5.64e-144***

0.832

2e-127***

T cell

CD3D

0.87

1.71e-161***

0.859

2.3e-144***

CD3E

0.939

1.51e-242***

0.933

5.57e-220***

CD2

0.938

4.26e-242***

0.932

1.49e-217***

B cell

CD19

0.588

6.64e-50***

0.558

1.52e-41***

CD79A

0.582

1.26e-48***

0.553

8.95e-41***

Monocyte

CD86

0.772

2.16e-104***

0.749

1.37e-89***

CD115 (CSF1R)

0.841

7.1e-141***

0.828

2.87e-125***

TAM

CCL2

0.587

1e-49***

0.553

1.01e-40***

CD68

0.473

1.85e-30***

0.457

9.69e-27***

IL10

0.618

2.29e-56***

0.58

1.28e-45***

M1 Macrophage

INOS (NOS2)

0.314

1.99e-13***

0.341

7.91e-15***

IRF5

0.358

3.2e-17***

0.378

3.71e-18***

COX2(PTGS2)

−0.147

7.7e-04***

−0.132

3.4e-03***

M2 Macrophage

CD163

0.71

3.84e-81***

0.701

8.05e-74***

VSIG4

0.642

4.64e-62***

0.638

1.43e-57***

MS4A4A

0.746

5.93e-94***

0.73

3.89e-83***

Neutrophils

CD66b (CEACAM8)

0.075

8.81e-02

0.059

1.9e-01

CD11b (ITGAM)

0.633

9.83e-60***

0.614

2.08e-52***

CCR7

0.749

3.41e-95***

0.726

1.37e-81***

Natural killer cell

KIR2DL1

0.398

2.86e-21***

0.4

2.39e-20***

KIR2DL3

0.555

1.38e-43***

0.549

4.7e-40***

KIR2DL4

0.639

2.37e-61***

0.639

7.05e-58***

KIR3DL1

0.509

9.34e-36***

0.508

1.16e-33***

KIR3DL2

0.651

2.58e-64***

0.644

5.71e-59***

KIR3DL3

0.261

1.52e-09***

0.253

1.33e-08***

KIR2DS4

0.409

1.85e-22***

0.386

6.8e-19***

Dendritic cell

HLA-DPB1

0.862

2.47e-155***

0.848

4.71e-137***

HLA-DQB1

0.698

2.36e-77***

0.678

1.42e-67***

HLA-DRA

0.858

1.69e-152***

0.844

2.04e-134***

HLA-DPA1

0.864

7.54e-157***

0.851

5.61e-139***

BDCA-1(CD1C)

0.54

7.3e-41***

0.489

6.57e-31***

BDCA-4(NRP1)

0.431

4.4e-25***

0.415

6.67e-22***

CD11c (ITGAX)

0.696

6.05e-77***

0.674

2.02e-66***

Th1

T -bet (TBX21)

0.896

5.71e-185***

0.888

2.99e-167***

STAT4

0.681

1.74e-72***

0.652

7.99e-61***

STAT1

0.623

1.97e-57***

0.605

1.95e-50***

IFN-γ (IFNG)

0.759

4.45e-99***

0.743

2.28e-87***

TNF-α (TNF)

0.227

1.62e-07***

0.2

7.51e-06***

Th2

GATA3

0.472

2.81e-30***

0.431

1.19e-23***

STAT6

0.323

3.55e-14***

0.371

1.87e-17***

STAT5A

0.661

9.69e-67***

0.654

2.84e-61***

IL13

0.481

1.47e-31***

0.456

1.09e-26***

Tfh

BCL6

0.122

5.09e-03

0.185

3.61e-05***

IL21

0.572

1.24e-46***

0.545

1.82e-39***

Th17

STAT3

0.395

6.09e-21***

0.399

2.85e-20***

IL17A

0.362

1.23e-17***

0.337

1.5e-14***

Treg

FOXP3

0.853

9.12e-149***

0.839

1.05e-131***

CCR8

0.752

4.31e-96***

0.728

1.89e-82***

STAT5B

0.431

5.72e-25***

0.43

1.43e-23***

TGFβ (TGFB1)

−0.012

7.89e-01

−0.028

5.42e-01

T cell exhaustion

PD-1 (PDCD1)

0.895

4.3e-184***

0.887

9.24e-167***

PDL1(PDCD1LG2)

0.593

6.31e-51***

0.567

3.74e-43***

CTLA4

0.823

1.06e-129***

0.808

1.07e-114***

LAG3

0.817

2.22e-126***

0.807

2.88e-114***

TIM-3 (HAVCR2)

0.879

2.91e-169***

0.873

6.53e-155***

GZMB

0.776

3.73e-106***

0.759

2.31e-93***