Region (n) | A*03 positivity, %b | A*03 allele frequency c | Reference |
|---|
Australia (129)d | 39.5 | 0.2519 | [13] |
Alabama (43)d | 58.1 | 0.3953 | [14] |
Italy (47)d | 61.7 | 0.3936 | [15] |
Alabama (180) | 78.3 | 0.4944 | present study |
Value of p |  < 0.0001 |  < 0.0001 |  |
- a Abbreviation: HLA human leukocyte antigen
- b Positivity is defined as either A*03 homozygosity or heterozygosity. Positivity in the Australia cohort was lower than that in the previous Alabama (n = 43), Italy, and the present Alabama (n = 180) cohorts (p = 0.0098, 0.0015, and < 0.0001, respectively; post-hoc Fisher's exact tests). Positivity in the previous Alabama (n = 43) and Italy cohorts was lower than that in the present Alabama (n = 180) cohort (p = 0.0106 and 0.0239, respectively; post-hoc Fisher's exact tests)
- c Allele frequency is defined as the quotient of total A*03 alleles by total A alleles. A*03 allele frequency in the Australia cohort was lower than that in the previous Alabama (n = 43) and present Alabama (n = 180) cohorts (p = 0.0133 and < 0.0001, respectively; post-hoc Fisher's exact tests). A*03 allele frequency was lower in the Italy cohort than in the present Alabama cohort (p = 0.0147; post-hoc Fisher's exact test)
- d Patients in these cohorts were not characterized by HFE genotyping
