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Table 4 Kyn and Trp serum levels in healthy controls and TB patients with R248W and Y359X genotypes (μmol/L)

From: Single-nucleotide polymorphisms and activities of indoleamine 2,3-dioxygenase isoforms, IDO1 and IDO2, in tuberculosis patients

Group

Healthy controls

Patients

R248W(TT) in patients

R248W(CC) in patients

Y359X(TT) in patients

Y359X(AA) in patients

N

60

64

10

6

8

4

Kyn

1.70 ± 0.35

2.42 ± 1.02*

2.83 ± 1.06

2.62 ± 1.11

2.59 ± 0.98

2.37 ± 1.15

Trp

52.55 ± 10.45

48.18 ± 16.56*

47.39 ± 13.74

49.11 ± 14.69

50.23 ± 15.72

51.37 ± 16.88

Kyn/Trp

0.032 ± 0.01

0.050 ± 0.028*

0.061 ± 0.029

0.053 ± 0.031

0.052 ± 0.033

0.046 ± 0.044

  1. *Significant differences between TB patients and healthy controls, P < 0.05
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Hereditas

ISSN: 1601-5223

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