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Table 4 Kyn and Trp serum levels in healthy controls and TB patients with R248W and Y359X genotypes (μmol/L)

From: Single-nucleotide polymorphisms and activities of indoleamine 2,3-dioxygenase isoforms, IDO1 and IDO2, in tuberculosis patients

Group Healthy controls Patients R248W(TT) in patients R248W(CC) in patients Y359X(TT) in patients Y359X(AA) in patients
N 60 64 10 6 8 4
Kyn 1.70 ± 0.35 2.42 ± 1.02* 2.83 ± 1.06 2.62 ± 1.11 2.59 ± 0.98 2.37 ± 1.15
Trp 52.55 ± 10.45 48.18 ± 16.56* 47.39 ± 13.74 49.11 ± 14.69 50.23 ± 15.72 51.37 ± 16.88
Kyn/Trp 0.032 ± 0.01 0.050 ± 0.028* 0.061 ± 0.029 0.053 ± 0.031 0.052 ± 0.033 0.046 ± 0.044
  1. *Significant differences between TB patients and healthy controls, P < 0.05