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Fig. 1 | Hereditas

Fig. 1

From: Single-nucleotide polymorphisms and activities of indoleamine 2,3-dioxygenase isoforms, IDO1 and IDO2, in tuberculosis patients

Fig. 1

Sanger sequence electropherograms of R248W and Y359X and the position of R248W and Y359X in the predicted 3D structure. (a) Three IDO2 genotypes were found in R248W and Y359X: wild type, heterocigoto type, and homocigoto type; (b) Mutations in the predicted 3D structure of IDO2 (red arrows). Structure prediction using the SWISS-MODEL server showed that IDO1 and IDO2 formed dimers. Interaction values of binding free energy (− 12.75 kcal/mol) and dissociation constant (4.50 e− 10 M) were estimated using the PPA-Pred2 online software (Protein-Protein Affinity Predictor; https://www.iitm.ac.in/bioinfo/PPA_Pred/prediction.html)

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Hereditas

ISSN: 1601-5223

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