Fig. 2
From: IFNAR1 gene mutation may contribute to developmental stuttering in the Chinese population
Schematic diagram of the mutations of human IFNAR1 identified in individuals with stuttering. A The human IFNAR1 protein is 557 amino acids long and consists of an N-terminal extracellular cytokine-binding (EC) domain (436 aa), a hydrophobic transmembrane (TM) domain (21 aa), and a C-terminal intracytoplasmic (IC) domain (100 aa). B The protein sequences of IFNAR1 in different organisms were aligned with the Clustal Omega program in the UniProt database. Its predicted orthologs show the conservation of the Gly301Glu, Pro335 and Lys428 residues. An * (asterisk) indicates positions that have a single, fully conserved residue. A (colon) indicates conservation between groups with highly similar properties — scoring > 0.5 in the Gonnet PAM 250 matrix. A (period) indicates conservation between groups with weakly similar properties — scoring =< 0.5 in the Gonnet PAM 250 matrix