Fig. 1
From: Somatic frameshift mutation in PIK3CA causes CLOVES syndrome by provoking PI3K/AKT/mTOR pathway
Clinical features of the patient. a-b The patient showed irregularly extended capillary malformations and asymmetrical hypertrophy of the lower limb. c Epidermal nevi. d Sandal gap toe and wide foot with second and third toes macrodactyly caused by skeletal elongation and adipose overgrowth. e Scoliosis and surgical removal of lipomatous masses. f X-ray examinations confirmed the asymmetrical overgrowth. g Decreased vascular anomalies and fat overgrowth of her lower limb after oral rapamycin treatment. h Removal of the left third toe by surgical amputation