Table 1 Thirty-seven genes correlated with HCC development in T2DM
Gene | Term | T2DM | HCC | ||
|---|---|---|---|---|---|
LogFC | P_value | LogFC | P_value | ||
CXCL5 | C-X-C Motif Chemokine Ligand 5 | 0.40 | 7.57E-03 | 1.65 | 1.95E-02 |
GPC3 | Glypican 3 | 0.39 | 6.27E-03 | 5.22 | 5.70E-08 |
NETO2 | Neuropilin And Tolloid Like 2 | 0.22 | 8.83E-03 | 1.39 | 1.14E-03 |
IGF2BP2 | Insulin Like Growth Factor 2 MRNA Binding Protein 2 | 0.22 | 4.10E-02 | 1.43 | 1.98E-02 |
ACAT1 | Acetyl-CoA Acetyltransferase 1 | -0.33 | 7.41E-04 | -1.47 | 4.35E-04 |
CRYL1 | Crystallin Lambda 1 | -0.29 | 1.18E-03 | -1.20 | 4.34E-03 |
SLC2A2 | Solute Carrier Family 2 Member 2 | -0.65 | 2.54E-03 | -1.88 | 1.13E-02 |
PCK1 | Phosphoenolpyruvate Carboxykinase 1 | -0.33 | 4.89E-02 | -3.96 | 3.27E-04 |
ABAT | 4-Aminobutyrate Aminotransferase | -0.50 | 2.75E-03 | -1.91 | 1.15E-02 |
ACADSB | Acyl-CoA Dehydrogenase Short/Branched Chain | -0.29 | 7.88E-04 | -1.76 | 2.39E-03 |
ST3GAL6 | ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 6 | -0.27 | 2.55E-02 | -2.15 | 1.29E-06 |
EPHX2 | Epoxide Hydrolase 2 | -0.32 | 1.07E-02 | -1.96 | 4.06E-04 |
KCNMA1 | Potassium Calcium-Activated Channel Subfamily M Alpha 1 | -0.34 | 2.10E-02 | -1.93 | 3.94E-07 |
SORL1 | Sortilin Related Receptor 1 | -0.42 | 1.01E-02 | -2.36 | 1.36E-07 |
ACYP2 | Acylphosphatase 2 | -0.25 | 1.51E-03 | -1.09 | 3.55E-03 |
QDPR | Quinoid Dihydropteridine Reductase | -0.26 | 4.17E-02 | -1.12 | 1.43E-02 |
TSPAN7 | Tetraspanin 7 | -0.52 | 3.92E-03 | -1.22 | 5.81E-03 |
MAN1C1 | Mannosidase Alpha Class 1C member 1 | -0.29 | 9.13E-03 | -1.74 | 2.16E-05 |
SC5D | Sterol-C5-Desaturase | -0.39 | 9.94E-04 | -1.61 | 3.96E-03 |
IRS2 | Insulin Receptor Substrate 2 | -0.21 | 1.99E-02 | -1.45 | 4.61E-03 |
RBL2 | RB Transcriptional Corepressor Like 2 | -0.27 | 1.10E-02 | -1.09 | 8.00E-03 |
F8 | Coagulation factor VIII | -0.20 | 2.28E-02 | -1.23 | 6.47E-04 |
PRKAR2B | Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta | -0.30 | 9.63E-03 | -1.56 | 1.25E-03 |
ETFDH | Electron Transfer Flavoprotein Dehydrogenase | -0.27 | 1.80E-02 | -1.61 | 3.04E-05 |
LIMCH1 | LIM And Calponin Homology Domains 1 | -0.29 | 4.39E-02 | -1.21 | 1.78E-02 |
HADH | 3-Hydroxyacyl-CoA Dehydrogenase | -0.33 | 8.97E-03 | -1.19 | 4.69E-04 |
ACSL1 | Acyl-CoA Synthetase Long Chain Family Member 1 | -0.43 | 1.36E-03 | -1.63 | 4.18E-03 |
PTS | 6-Pyruvoyltetrahydropterin Synthase | -0.21 | 4.82E-02 | -1.20 | 1.83E-04 |
PHLDA2 | Pleckstrin Homology Like Domain Family A Member 2 | 0.29 | 8.18E-03 | 1.47 | 2.22E-02 |
GAS2 | Growth Arrest Specific 2 | -0.28 | 4.53E-02 | -1.09 | 1.28E-02 |
TGFBR3 | Transforming Growth Factor Beta Receptor 3 | -0.45 | 2.95E-03 | -1.25 | 1.96E-03 |
PEMT | Phosphatidylethanolamine N-Methyltransferase | -0.21 | 4.74E-02 | -1.43 | 4.27E-04 |
PTPN3 | Protein Tyrosine Phosphatase Non-Receptor Type 3 | -0.33 | 1.76E-03 | -1.07 | 2.35E-03 |
PPP1R1A | Protein Phosphatase 1 Regulatory Inhibitor Subunit 1A | -0.74 | 5.26E-05 | -1.59 | 2.55E-02 |
RNF130 | Ring Finger Protein 130 | -0.22 | 1.90E-03 | -1.24 | 2.20E-02 |
RCBTB2 | RCC1 And BTB Domain Containing Protein 2 | -0.30 | 9.65E-03 | -1.26 | 3.23E-05 |
OAT | Ornithine Aminotransferase | -0.49 | 8.27E-04 | -2.50 | 1.86E-03 |