Table 3 KEGG pathway of up-regulated and down-regulated DEGs
ID | Description | Adjusted P-values | Gene symbol | Count |
|---|---|---|---|---|
Up-regulated | ||||
 hsa04062 | Chemokine signaling pathway | 1.90E-14 | CXCL9/CXCL10/CCL18/CXCL6/CCL5/CCR5/STAT1/CCR2/ITK/PRKCB/NCF1/CXCL13/RAC2/CCR7/CXCL5/CXCL11/CXCR4/CCL13/ADCY7/CXCR6/CXCR3/DOCK2/PRKCZ/XCL1/JAK2/PRKACB/PIK3CG/CCR1/WAS/VAV1/CXCL1/PIK3CD/HCK/CX3CR1/CCL19/CCL7/CXCR5/ARRB2/GNAI2/STAT2/CCR6/FGR/PRKCD | 43 |
 hsa04640 | Hematopoietic cell lineage | 8.51E-13 | HLA-DOB/MS4A1/IL7R/ITGA4/CD38/CD2/CD8A/CD3D/HLA-DMB/CSF1R/CD19/3ADCY7/HLA-DMA/CD3E/HLA-DPB1/CD37/HLA-DQB1/CR1/HLA-DRA/CD14/CD4/IL2RA/CSF3R/FLT3LG/CD1B/CD24/CD3G/CD7/CSF2RA | 29 |
 hsa04060 | Cytokine-cytokine receptor interaction | 4.76E-12 | TNFRSF17/CXCL9/CD27/CXCL10/IL21R/CCL18/TNFSF11/CXCL6/CCL5/IL7R/IL2RG/CCR5/IL32/CCR2/CSF2RB/CXCL13/CSF1R/CCR7/IL15/CXCL5/IL23A/CXCL11/CXCR4/CCL13/CXCR6/CXCR3/TNFSF10/LTB/XCL1/IL27RA/TNFRSF4/CD4/CCR1/IL10RA/CXCL1/IL2RA/CSF3R/IL15RA/CX3CR1/FAS/IL18/CCL19/IFNA21/CD40LG/CCL7/TNFSF13/IL1RL1/CXCR5/CSF2RA/CCR6 | 50 |
 hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 6.00E-12 | CXCL9/CXCL10/CCL18/CXCL6/CCL5/IL2RG/CCR5/CCR2/CXCL13/CSF1R/CCR7/CXCL5/CXCL11/CXCR4/CCL13/CXCR3/TNFSF10/XCL1/CCR1/IL10RA/CXCL1/IL2RA/CX3CR1/IL18/CCL19/CCL7/CXCR5/CCR6 | 28 |
 hsa05340 | Primary immunodeficiency | 7.15E-11 | CD79A/LCK/BLNK/IL7R/IL2RG/PTPRC/CD8A/CD3D/CD19/CD3E/TAP1/RFX5/ZAP70/CD4/ICOS/IGLL1/CD40LG | 17 |
 hsa05140 | Leishmaniasis | 1.16E-10 | HLA-DOB/ITGA4/STAT1/HLA-DMB/PRKCB/NCF1/ITGB2/3ADCY7/HLA-DMA/HLA-DPB1/CYBA/CYBB/CD1B3/HLA-DQB1/CR1/HLA-DRA/PTPN6/FCGR3B/JAK2/MARCKSL1/NCF2/MAPK13/NCF4 | 23 |
 hsa04380 | Osteoclast differentiation | 4.24E-10 | TNFSF11/LCK/BLNK/STAT1/NCF1/CSF1R/FCGR2B/PLCG2/SYK/LILRB2/CYBA/LILRB4/LILRB1/CD1B3/LILRB3/FCGR3B/SIRPG/LILRA3/LCP2/PIK3CD/NCF2/MAPK13/NCF4/TREM2/TYROBP/ACP5/7CD3E8/STAT2/SPI1 | 29 |
 hsa05323 | Rheumatoid arthritis | 1.27E-09 | MMP1/HLA-DOB/TNFSF11/CXCL6/CCL5/HLA-DMB/MMP3/ITGB2/ITGAL/3ADCY7/IL15/HLA-DMA/CXCL5/IL23A/HLA-DPB1/CD86/HLA-DQB1/LTB/HLA-DRA/CXCL1/CTLA4/IL18/TNFSF13/ACP5 | 24 |
Down-regulated | ||||
 hsa03320 | PPAR signaling pathway | 0.000189284 | PLIN1/PCK1/ADIPOQ/ACADL/FABP4/LPL | 6 |
 hsa04923 | Regulation of lipolysis in adipocytes | 0.000398572 | PLIN1/ADCY2/NPY1R/FABP4/PTGS2 | 5 |
 hsa04920 | Adipocytokine signaling pathway | 0.000818815 | ADCY291/PCK1/LEP/ADIPOQ/ACACB | 5 |
 hsa04922 | Glucagon signaling pathway | 0.004887657 | ADCY2/ADCY291/PHKA1/PCK1/ACACB | 5 |
 hsa04152 | AMPK signaling pathway | 0.006451484 | ADCY291/PCK1/LEP/ADIPOQ/ACACB | 5 |
 hsa04020 | Calcium signaling pathway | 0.006451484 | ADCY2/PHKA1/EDNRB/PLN/TNNC2/AGTR1 | 6 |
 hsa04918 | Thyroid hormone synthesis | 0.008113772 | ADCY2/ATP1A2/DUOX2/GPX3 | 4 |
 hsa04371 | Apelin signaling pathway | 0.008113772 | PLIN1/ADCY2/ADCY291/23710/AGTR1 | 5 |
 hsa04022 | cGMP-PKG signaling pathway | 0.016012172 | ADCY2/EDNRB/ATP1A2/PLN/AGTR1 | 5 |
 hsa04925 | Aldosterone synthesis and secretion | 0.016012172 | ADCY2/ATP1A2/KCNK3/AGTR1 | 4 |