Skip to main content

Table 4 Allelic and genotypic association of 9 SNPs in LAMC1 gene with POP

From: Common variants in LAMC1 confer risk for pelvic organ prolapse in Chinese population

SNP Sample N Allele frequency (%) OR (95% CI) χ2 P Genotype frequency (%) χ2 P
rs20558    C T     CC CT TT   
  POP 159 192 (60.4) 126 (39.6) 1.192 (0.888–1.601) 1.372 0.241 64 (40.3) 64 (40.3) 31 (19.4) 1.393 0.498
  CTR 231 298 (64.5) 164 (35.5) 102 (44.2) 94 (40.7) 35 (15.2)
rs10911193    C T     CC CT TT   
  POP 160 277 (86.6) 43 (13.4) 1.397 (0.899–2.170) 2.229 0.135 123 (76.9) 31 (19.4) 6 (3.8) 2.270 0.321
  CTR 235 423 (90.0) 47 (10.0)    192 (81.7) 39 (16.6) 4 (1.7)
rs6424889    C G     CC CG GG   
  POP 160 201 (62.8) 119 (37.2) 1.003 (0.746–1.350) 4.67 E-04 0.957 72 (45.0) 57 (35.6) 31 (19.4) 1.403 0.496
  CTR 225 283 (62.9) 167 (37.1) 95 (42.2) 93 (41.3) 37 (16.4)
rs10911241    A G     AA AG GG   
  POP 160 103 (32.2) 217 (67.8) 1.709 (1.238–2.359) 10.70 1.1 E-03 82 (51.3) 53 (33.1) 25 (15.6) 14.98 5.6 E-04a
  CTR 230 100 (21.7) 360 (78.3) 140 (60.9) 80 (34.8) 10 (4.3)
rs3768617    C T     CC CT TT   
  POP 156 117 (37.5) 195 (62.5) 0.912 (0.678–1.226) 0.540 0.912 59 (37.8) 77 (49.4) 20 (12.8) 0.423 0.809
  CTR 228 181 (39.7) 275 (60.3) 81 (35.5) 113 (49.6) 34 (14.9)
rs12073936    T G     TT TG GG   
  POP 161 283 (87.9) 39 (12.1) 1.200 (0.766–1.880) 0.636 0.425 126 (78.3) 31 (19.3) 4 (2.5) 0.916 0.633
  CTR 233 418 (89.7) 48 (10.3) 188 (80.7) 42 (18.0) 3 (1.3)
rs729819    A G     AA AG GG   
  POP 159 197 (61.9) 121 (38.1) 1.115 (0.829–1.500) 0.515 0.473 57 (35.8) 83 (52.2) 19 (11.9) 1.693 0.429
  CTR 228 294 (64.5) 162 (35.5) 95 (41.7) 104 (45.6) 29 (12.7)
rs10911214    T C     TT TC CC   
  POP 156 239 (76.6) 73 (23.4) 1.270 (0.895–1.804) 1.795 0.180 99 (63.5) 41 (26.3) 16 (10.3) 7.637 0.022
  CTR 227 366 (80.6) 88 (19.4) 147 (64.8) 72 (31.7) 8 (3.5)
rs869133    G C     GG GC CC   
  POP 159 297 (93.4) 21 (6.6) 1.118 (0.620–2.016) 0.138 0.710 139 (87.4) 19 (11.9) 1 (0.6) 0.386 0.824
  CTR 227 427 (94.1) 27 (5.9) 202 (89.0) 23 (10.1) 2 (0.9)
  1. POP Pelvic organ prolapse, CTR Control, SNP Single-nucleotide polymorphism, CI Confidence interval, OR Odds ratio
  2. aGlobal P-value was 7.1 E-03 after 10,000 permutations