Table 4 Allelic and genotypic association of 9 SNPs in LAMC1 gene with POP
From: Common variants in LAMC1 confer risk for pelvic organ prolapse in Chinese population
SNP | Sample | N | Allele frequency (%) | OR (95% CI) | χ2 | P | Genotype frequency (%) | χ2 | P | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
rs20558 | C | T | CC | CT | TT | |||||||
POP | 159 | 192 (60.4) | 126 (39.6) | 1.192 (0.888–1.601) | 1.372 | 0.241 | 64 (40.3) | 64 (40.3) | 31 (19.4) | 1.393 | 0.498 | |
CTR | 231 | 298 (64.5) | 164 (35.5) | 102 (44.2) | 94 (40.7) | 35 (15.2) | ||||||
rs10911193 | C | T | CC | CT | TT | |||||||
POP | 160 | 277 (86.6) | 43 (13.4) | 1.397 (0.899–2.170) | 2.229 | 0.135 | 123 (76.9) | 31 (19.4) | 6 (3.8) | 2.270 | 0.321 | |
CTR | 235 | 423 (90.0) | 47 (10.0) | 192 (81.7) | 39 (16.6) | 4 (1.7) | ||||||
rs6424889 | C | G | CC | CG | GG | |||||||
POP | 160 | 201 (62.8) | 119 (37.2) | 1.003 (0.746–1.350) | 4.67 E-04 | 0.957 | 72 (45.0) | 57 (35.6) | 31 (19.4) | 1.403 | 0.496 | |
CTR | 225 | 283 (62.9) | 167 (37.1) | 95 (42.2) | 93 (41.3) | 37 (16.4) | ||||||
rs10911241 | A | G | AA | AG | GG | |||||||
POP | 160 | 103 (32.2) | 217 (67.8) | 1.709 (1.238–2.359) | 10.70 | 1.1 E-03 | 82 (51.3) | 53 (33.1) | 25 (15.6) | 14.98 | 5.6 E-04a | |
CTR | 230 | 100 (21.7) | 360 (78.3) | 140 (60.9) | 80 (34.8) | 10 (4.3) | ||||||
rs3768617 | C | T | CC | CT | TT | |||||||
POP | 156 | 117 (37.5) | 195 (62.5) | 0.912 (0.678–1.226) | 0.540 | 0.912 | 59 (37.8) | 77 (49.4) | 20 (12.8) | 0.423 | 0.809 | |
CTR | 228 | 181 (39.7) | 275 (60.3) | 81 (35.5) | 113 (49.6) | 34 (14.9) | ||||||
rs12073936 | T | G | TT | TG | GG | |||||||
POP | 161 | 283 (87.9) | 39 (12.1) | 1.200 (0.766–1.880) | 0.636 | 0.425 | 126 (78.3) | 31 (19.3) | 4 (2.5) | 0.916 | 0.633 | |
CTR | 233 | 418 (89.7) | 48 (10.3) | 188 (80.7) | 42 (18.0) | 3 (1.3) | ||||||
rs729819 | A | G | AA | AG | GG | |||||||
POP | 159 | 197 (61.9) | 121 (38.1) | 1.115 (0.829–1.500) | 0.515 | 0.473 | 57 (35.8) | 83 (52.2) | 19 (11.9) | 1.693 | 0.429 | |
CTR | 228 | 294 (64.5) | 162 (35.5) | 95 (41.7) | 104 (45.6) | 29 (12.7) | ||||||
rs10911214 | T | C | TT | TC | CC | |||||||
POP | 156 | 239 (76.6) | 73 (23.4) | 1.270 (0.895–1.804) | 1.795 | 0.180 | 99 (63.5) | 41 (26.3) | 16 (10.3) | 7.637 | 0.022 | |
CTR | 227 | 366 (80.6) | 88 (19.4) | 147 (64.8) | 72 (31.7) | 8 (3.5) | ||||||
rs869133 | G | C | GG | GC | CC | |||||||
POP | 159 | 297 (93.4) | 21 (6.6) | 1.118 (0.620–2.016) | 0.138 | 0.710 | 139 (87.4) | 19 (11.9) | 1 (0.6) | 0.386 | 0.824 | |
CTR | 227 | 427 (94.1) | 27 (5.9) | 202 (89.0) | 23 (10.1) | 2 (0.9) | ||||||