Table 3 The nodes with degree more than 20 in the integrated network based on upregulated DEGs, transcription factor (TFs), and miRNA. The blod fonts indicate miRNA, the italic indicate TFs
From: microRNA-9 might be a novel protective factor for osteoarthritis patients
Symbol | Degree | Symbol | Degree |
|---|---|---|---|
FOS | 51.0 | MIR-30D | 27.0 |
COL1A1 | 36.0 | MIR-30C | 27.0 |
CCND1 | 36.0 | MIR-30A-5P | 27.0 |
ATP2A2 | 35.0 | SMAD6 | 26.0 |
APP | 35.0 | TIMP1 | 25.0 |
MMP2 | 34.0 | PTGS2 | 25.0 |
NRAS | 34.0 | HIC2 | 25.0 |
FN1 | 34.0 | FNDC3B | 25.0 |
SMAD7 | 34.0 | TIMP3 | 24.0 |
EGR3 | 33.0 | PRRX1 | 24.0 |
MIR-519D | 32.0 | SOX9 | 23.0 |
MIR-20B | 32.0 | MIR-524 | 23.0 |
MIR-106B | 32.0 | MIR-124A | 22.0 |
MIR-106A | 32.0 | GLI3 | 22.0 |
MIR-20A | 32.0 | MIR-9 | 22.0 |
MIR-17-5P | 32.0 | CCND2 | 22.0 |
EGR1 | 30.0 | MIR-429 | 21.0 |
IGF1 | 29.0 | MIR-200C | 21.0 |
NR4A2 | 29.0 | MIR-200B | 21.0 |
EP300 | 28.0 | PRKACB | 21.0 |
APOE | 27.0 | EDEM3 | 21.0 |
MIR-30E-5P | 27.0 | SOX4 | 21.0 |
MIR-30B | 27.0 | ZNF512B | 21.0 |