Fig. 1
From: Detect accessible chromatin using ATAC-sequencing, from principle to applications
The mechanism of identifying chromatin accessibility using the Tn5 transposase. a Open and closed status of chromatin. b When the chromatin accessibility is increased, the Tn5 transposase transpose in the open chromatin more often than in the inaccessible chromatin. Then the Tn5 transposase cuts the open chromatin and tags the adaptors to it to generate DNA fragments. The green symbol represents “adapter 1” of the Tn5 transposase, while the red symbol represents “adapter 2” of theTn5 transposase