Integrated identification of key genes and pathways in Alzheimer’s disease via comprehensive bioinformatical analyses

Table 6 Detailed information of hub genes

Hub genes	Involved cell functions	References
Hippocampus
CDC42	actin cytoskeleton, gene expression, cell proliferation, Aβ neurotoxicity	[69,70,71,72]
VEGFA	neurogenesis, neuronal migration	[73,74,75]
BDNF	growth, survival and maintenance of neurons	[76, 77]
PDYN	memory, learning, and cognitive functions; drug consumption and addiction	[78,79,80]
CALB	long-term potentiation, synaptic plasticity, and memory functions	[81, 82]
TH	memory and recognition functions	[83, 84]
CACNA1A	learning and memory	[85, 86]
CD44	inflammation-related functions	[87,88,89]
TAC1	neurotrophic and inflammation related functions	[90, 91]
Entorhinal cortex
OXT	drug addiction, anxiety and memory formation	[92,93,94]
TAC1	neurotrophic and inflammation related functions	[90, 91]

ISSN: 1601-5223