A new model of the mechanism underlying lead poisoning: SNP in miRNA target region influence the AGT expression level

Table 2 Angiotensinogen gene (AGT) re7079 allele frequencies in the lead-exposed and unexposed (control) population, and the association of these polymorphisms with lead exposure

Genotypes	BLL1^a (n = 190)		BLL2^b (n = 114)		P ^c	Crude OR (95% CI)	Adjusted OR (95% CI)^d
Genotypes	N	%	N	%	P ^c	Crude OR (95% CI)	Adjusted OR (95% CI)^d
rs7079
CC	100	52.6	76	66.7	0.04	1.00	1.00
CA	88	46.3	36	31.6		1.86 (1.14–3.03)	2.27 (1.33–3.86)
AA	2	1.1	2	1.7		0.76 (0.11–5.52)	0.93 (0.12–7.31)
CA + AA	90	47.4	38	33.3	0.02	1.80 (1.11–2.92)	1.92 (1.16–3.18)
A Allele	92	24.2	92	17.5	0.08

The observed genotype frequency among the control subjects was in agreement with Hardy-Weinberg equilibrium (p² + 2pq + q² = 1) (χ² = 0.954, P = 0.329 for rs7079
^a Blood lead level (BLL) < 200 μg/L
^b Blood lead level (BLL) ≥ 400 μg/L
^c Two-sided χ² test for either genotype or allele frequency
^d Obtained from logistic regression models adjusted for age, sex, and smoking habits

ISSN: 1601-5223