Fig. 3

Correlation between the ancestral allele frequencies and latitude coordinates for the variants (a) rs699 (AGT), (b) rs5443 (GNB3), (c) rs776746 (CYP3A5), (d) rs4343 (ACE) and (e) rs4293393 (UMOD). Variant rs4343 is in strong linkage disequilibrium with the ACE I/D polymorphism. The ancestral allele A is linked with the insertion polymorphism. Significant correlations between the ancestral variant frequencies and the latitude coordinates are shown in all variants tested except rs4309 and rs4293393. However, distinct clusters are observed which indicates significant different ancestral allele frequencies between African, European, East Asian and American populations. ACB, African Carribean; ASW, African in Southwest US; BEB, Bengali in Bangladesh; CDX, Chinese Dai; CEU, European in Centre Utah; CHB, Han Chinese Beijing; CHS, Southern Han Chinese; CLM, Colombian; ESN, Esan Nigeria; Fin, Finnish, GBR, British; GIH, Gujurati Indian in Houston; GWD, Gambian; IBS, Iberian Spain; ITU, Indian Telugu in UK; JPT, Japanese Tokyo; KHV, Kinh Vietnam; LWK, Luhya Kenya; MSL, Mende in Sierra Leone Africa; MXL, Mexican in California; PEL, Peruvian; PJL, Punjabi Pakistan; PUR; Puerto Rican; STU, Sri Lankan; TSI, Toscani Italy; YRI, Yoruba Nigeria