Common variants in the SLC28A2 gene are associated with serum uric acid level and hyperuricemia and gout in Han Chinese

Table 2 Results of the seven SNPs in gout versus control cohort, HUA versus control cohort, gout versus HUA cohort and gout+HUA versus control cohort

SNP	A1	F_Gout	F_HUA	F_Gout+HUA	F_Ctrl	HWE P	Gout vs Ctrl OR	Gout vs Ctrl P	Gout vs Ctrl Pperm	HUA vs Ctrl OR	HUA vs Ctrl P	HUA vs Ctrl Pperm	Gout vs HUA OR	Gout vs HUA P	Gout vs HUA Pperm	Gout+HUA vs Ctrl OR	Gout+HUA vs Ctrl P	Gout+HUA vs Ctrl Pperm
rs11854484	T	0.0480	0.0543	0.0510	0.0541	0.576	0.8822	0.3061	0.3333	1.003	0.9810	1	0.879	0.2985	0.3256	0.9402	0.5567	0.8571
rs2413775	T	0.1890	0.1843	0.1867	0.1998	0.754	0.9321	0.3088	0.3256	0.9033	0.1503	0.2419	1.032	0.6584	0.75	0.9179	0.1552	0.2344
rs2413769	T	0.1701	0.1624	0.1664	0.1868	0.465	0.8883	0.1005	0.0914	0.8406	0.0184	0.0172	1.059	0.4440	0.5625	0.8645	0.0202	0.0324
rs1060896	A	0.0493	0.0574	0.0532	0.0542	0.980	0.9056	0.4176	0.4	1.063	0.6112	0.6667	0.852	0.1899	0.2273	0.9813	0.8572	1
rs2271437	G	0.0418	0.0368	0.0394	0.0308	0.801	1.387	0.0277	0.0288	1.205	0.2236	0.35	1.145	0.3439	0.5	1.298	0.0499	0.0667
rs11639349	T	0.0422	0.0557	0.0487	0.0415	0.067	1.016	0.9077	0.8571	1.363	0.0171	0.0219	0.7419	0.0213	0.0211	1.181	0.1510	0.1589
rs16941238	A	0.1170	0.1043	0.1108	0.1301	0.060	0.8801	0.1315	0.1491	0.7734	0.0033	0.0020	1.142	0.1337	0.1328	0.8279	0.0101	0.0140
rs765787	C	0.3416	0.3433	0.3424	0.3340	0.008	1.037	0.54	0.7	1.045	0.462	0.75	0.9921	0.8927	1	1.041	0.4385	0.5625

A1, minor allele for the whole sample, namely the effect allele (the one that the reported OR correlates with); F_Gout, frequency of A1 in the gout cohort; F_HUA, frequency of A1 in the HUA cohort; F_Gout+HUA, frequency of A1 in the Gout+HUA cohort; F_Ctrl, frequency of A1 in the control cohort; OR, odds ratio; P, P value; Pperm, empirical permutation p values were permutated randomly with up to 1,000,000 trials. Pperm< 0.05 as the significance threshold and significant p values in bold

ISSN: 1601-5223