Table 2 The list of miRNAs of peripheral blood that can be used as biomarkers of schizophrenia
From: MiRNAs of peripheral blood as the biomarker of schizophrenia
MiRNA | Biological functionality | Direction associated with schizophrenia | As Biomarkers | Author (Refs.) |
|---|---|---|---|---|
miRNA30e | Mitosis, cell division, etc | up-regulation | hsa-miRNA30e | Sun et al. [35] (2014) |
miR-130b | nervous system development, neuron differentiation, etc | up-regulation | hsa-miR-130b | Wei et al. [41](2015) |
miR-193a-3p | neuron migration, nervous system development, etc | up-regulation | hsa-miR-193a-3p | |
miR-30e | as above | up-regulation | hsa-miR-30e, hsa-miR-181b, hsa-miR-34a, hsa-miR-346 and hsa-miR-7 as a whole | Sun et al. [36] (2015) |
miR-181b | central nervous system development, aging, etc | up-regulation | ||
miR-34a | neuron migration, generation of neurons, organ regeneration, etc | up-regulation | ||
miR-346 | response to stress, nervous system development, learning or memory, etc | up-regulation | ||
miR-7 | dendrite development, cellular response to stress, etc | up-regulation | ||
miR-34a | as above | up-regulation | hsa-miR-34a | Lai et al. [33] (2016) |
miR-449a | neuron apoptotic process, cellular response to hypoxia, etc | up-regulation | hsa-miR-449a | |
miR-564 | PI3K signaling networks, MAPK signaling pathway, etc | up-regulation | hsa-miR-564 | |
miR-432 | PI3K/AKT/mTOR signaling pathway, cell proliferation and differentiation, etc | up-regulation | hsa-miR-432 | |
miR-548d | nervous system development, positive regulation of rho gtpase activity, etc | up-regulation | hsa-miR-548d | |
miR-572 | cellular response to extracellular stimulus, organ regeneration, response to hyperoxia, etc | up-regulation | hsa-miR-572 | |
miR-652 | regulation of energy homeostasis, dendrite morphogenesis, etc | up-regulation | hsa-miR-652 | |
miR-30a-5p | response to hypoxia, neuron migration, immune response, etc | down regulation | EGR1-miR-30a-5p-NEUROD1 axis | Liu et al. [42] (2017) |