The Mendelian Society of Lund has been publishing the journal Hereditas since 1920.
Articles
Page 1 of 7
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Citation: Hereditas 2024 161:13
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Huanglian-Hongqu herb pair improves nonalcoholic fatty liver disease via NF-κB/NLRP3 pathway in mice: network pharmacology, molecular docking and experimental validation
The Huanglian-Hongqu herb pair (HH) is a carefully crafted traditional Chinese herbal compound designed to address disorders related to glucose and lipid metabolism. Its primary application lies in treating hy...
Citation: Hereditas 2024 161:12 -
A guide to barley mutants
Mutants have had a fundamental impact upon scientific and applied genetics. They have paved the way for the molecular and genomic era, and most of today’s crop plants are derived from breeding programs involvi...
Citation: Hereditas 2024 161:11 -
Bioinformatic analysis and experimental validation of cuproptosis-related LncRNA as a novel biomarker for prognosis and immunotherapy of oral squamous cell carcinoma
The novel form of regulatory cell death, cuproptosis, is characterized by proteotoxicity, which ultimately leads to cell death. Its targeting has emerged as a promising therapeutic approach for oral squamous c...
Citation: Hereditas 2024 161:10 -
A novel mutation in the FGG gene causes hypofibrinogenemia in a Chinese family
Congenital fibrinogen disorders are a group of coagulation deficiencies caused by fibrinogen defects and are divided into four types, including afibrinogenemia, hypofibrinogenemia, dysfibrinogenemia, and hypod...
Citation: Hereditas 2024 161:9 -
Genetic analysis of albinism caused by compound heterozygous mutations of the OCA2 gene in a Chinese family
Oculocutaneous albinism (OCA) is a group of rare genetic disorders characterized by a reduced or complete lack of melanin in the skin, hair, and eyes. Patients present with colorless retina, pale pink iris, an...
Citation: Hereditas 2024 161:8 -
Integrative single-cell analysis: dissecting CD8 + memory cell roles in LUAD and COVID-19 via eQTLs and Mendelian Randomization
Lung adenocarcinoma exhibits high incidence and mortality rates, presenting a significant health concern. Concurrently, the COVID-19 pandemic has emerged as a grave global public health challenge. Existing lit...
Citation: Hereditas 2024 161:7 -
Comprehensive analysis revealed the immunoinflammatory targets of rheumatoid arthritis based on intestinal flora, miRNA, transcription factors, and RNA-binding proteins databases, GSEA and GSVA pathway observations, and immunoinfiltration typing
Rheumatoid arthritis (RA) is a chronic inflammatory arthritis. This study aimed to identify potential biomarkers and possible pathogenesis of RA using various bioinformatics analysis tools.
Citation: Hereditas 2024 161:6 -
Correction: Identification of five hub genes as monitoring biomarkers for breast cancer metastasis in silico
Citation: Hereditas 2024 161:5 -
A novel missense mutation (FGG c.1168G > T) in the gamma chain of fibrinogen causing congenital hypodysfibrinogenemia with bleeding phenotype
Fibrinogen plays pivotal roles in multiple biological processes. Genetic mutation of the fibrinogen coding genes can result in congenital fibrinogen disorders (CFDs). We identified a novel heterozygous missens...
Citation: Hereditas 2024 161:4 -
Extracellular vesicle-derived TP53BP1, CD34, and PBX1 from human peripheral blood serve as potential biomarkers for the assessment and prediction of vascular aging
Vascular aging is an important pathophysiological basis for the senescence of various organs and systems in the human body, and it is a common pathogenetic trigger for many chronic diseases in the elderly.
Citation: Hereditas 2024 161:3 -
Network pharmacology to unveil the mechanism of suanzaoren decoction in the treatment of alzheimer’s with diabetes
Suanzaoren Decoction (SZRD), a well-known formula from traditional Chinese medicine, has been shown to have reasonable cognitive effects while relaxing and alleviating insomnia. Several studies have demonstrat...
Citation: Hereditas 2024 161:2 -
Revisiting bicoid function: complete inactivation reveals an additional fundamental role in Drosophila egg geometry specification
The bicoid (bcd) gene in Drosophila has served as a paradigm for a morphogen in textbooks for decades. Discovered in 1986 as a mutation affecting anterior development in the embryo, its expression pattern as a pr...
Citation: Hereditas 2024 161:1 -
Mechanisms of Actinidia chinensis Planch in treating colon cancer based on the integration of network pharmacology, molecular docking, and experimental verification
As an anticancer Chinese herbal medicine, the effective components and mechanism of Actinidia chinensis Planch (ACP, Tengligen) in the treatment of colon cancer are still unclear. In the present study, the integr...
Citation: Hereditas 2023 160:39 -
A pan-cancer analysis of Dyskeratosis congenita 1 (DKC1) as a prognostic biomarker
Dyskeratosis congenita 1 (DKC1), a critical component of telomerase complex, is highly expressed in a variety of human cancers. However, the association of DKC1 with cancer occurrence and development stages is...
Citation: Hereditas 2023 160:38 -
A novel mutation of CTC1 leads to telomere shortening in a chinese family with interstitial lung disease
Interstitial lung diseases (ILDs), or diffuse pulmonary lung disease, are a subset of lung diseases that primarily affect lung alveoli and the space around interstitial tissue and bronchioles. It clinically ma...
Citation: Hereditas 2023 160:37 -
Insulin-like growth factor binding protein 2: a core biomarker of left ventricular dysfunction in dilated cardiomyopathy
RNA modifications, especially N6-methyladenosine, N1-methyladenosine and 5–methylcytosine, play an important role in the progression of cardiovascular disease. However, its regulatory function in dilated cardi...
Citation: Hereditas 2023 160:36 -
Correction to: Performance comparison of four types of target enrichment baits for exome DNA sequencing
Citation: Hereditas 2023 160:35 -
Construction and validation of a cuproptosis-related diagnostic gene signature for atrial fibrillation based on ensemble learning
Atrial fibrillation (AF) is the most common type of cardiac arrhythmia. Nonetheless, the accurate diagnosis of this condition continues to pose a challenge when relying on conventional diagnostic techniques. C...
Citation: Hereditas 2023 160:34 -
Elevated HMGB1 promotes the malignant progression and contributes to cisplatin resistance of non-small cell lung cancer
HMGB1 (high mobility group box B-1) exhibits crucial role in tumor genesis and development, including lung cancer. Whereas, more HMGB1-related details in non-small cell lung cancer (NSCLC) are still largely un...
Citation: Hereditas 2023 160:33 -
Significance of methylation-related genes in diagnosis and subtype classification of renal interstitial fibrosis
RNA methylation modifications, such as N1-methyladenosine/N6-methyladenosine /N5-methylcytosine (m1A/m6A/m5C), are the most common RNA modifications and are crucial for a number of biological processes. Nonethele...
Citation: Hereditas 2023 160:32 -
A cuproptosis-related lncRNA signature for predicting prognosis and immunotherapy response of lung adenocarcinoma
Copper-induced cell death (cuproptosis) is a new regulatory cell death mechanism. Long noncoding RNAs (lncRNAs) are related to tumor immunity and metastasis. However, the correlation of cuproptosis-related lnc...
Citation: Hereditas 2023 160:31 -
An 8-gene predicting survival model of hepatocellular carcinoma (HCC) related to pyroptosis and cuproptosis
The study aimed to establish a prognostic survival model with 8 pyroptosis-and-cuproptosis-related genes to examine the prognostic effect in patients of hepatocellular carcinoma (HCC).
Citation: Hereditas 2023 160:30 -
Enhancer-driven transcription of MCM8 by E2F4 promotes ATR pathway activation and glioma stem cell characteristics
Glioma stem cells (GSCs) are responsible for glioma recurrence and drug resistance, yet the mechanisms underlying their maintenance remains unclear. This study aimed to identify enhancer-controlled genes invol...
Citation: Hereditas 2023 160:29 -
Mutations in the acetolactate synthase (ALS) enzyme affect shattercane (Sorghum bicolor) response to ALS-inhibiting herbicides
Shattercane [Sorghum bicolor (L.) Moench ssp. Arundinaceum (Desv.)] is a competitive weed in North America's corn, soybean, sorghum, and other agronomic crops. Control of shattercane with POST herbicides in co...
Citation: Hereditas 2023 160:28 -
NPM3 as a novel oncogenic factor and poor prognostic marker contributes to cell proliferation and migration in lung adenocarcinoma
Lung cancer is the leading cause of cancer-related deaths worldwide, and despite recent advances in targeted therapies and immunotherapies, the clinical benefit remains limited. Therefore, there is an urgent n...
Citation: Hereditas 2023 160:27 -
LncRNA WAC-AS1 expression in human tumors correlates with immune infiltration and affects prognosis
WAC-antisense RNA1 (WAC-AS1) is a newly identified long non-coding RNA (lncRNA) implicated in the prognosis and development of a few types of tumors. However, the correlations of WAC-AS1 with immune infiltrati...
Citation: Hereditas 2023 160:26 -
Identifying and predicting the pathogenic effects of a novel variant inducing severe early onset MMA: a bioinformatics approach
Methylmalonic acidemia (MMA) is a rare metabolic disorder resulting from functional defects in methylmalonyl-CoA mutase. Mutations in the MMAB gene are responsible for the cblB type of vitamin B12-responsive MMA.
Citation: Hereditas 2023 160:25 -
Correction: Genomics in animal breeding from the perspectives of matrices and molecules
Citation: Hereditas 2023 160:24 -
EZH2 regulates pancreatic cancer cells through E2F1, GLI1, CDK3, and Mcm4
Pancreatic cancer (PC) is one of the most common malignant tumors in digestive tract. To explore the role of epigenetic factor EZH2 in the malignant proliferation of PC, so as to provide effective medical help in...
Citation: Hereditas 2023 160:23 -
Whole-exome sequencing detected a novel AIFM1 variant in a Han-Chinese family with Cowchock syndrome
Charcot-Marie-Tooth disease(CMT) is a hereditary peripheral neuropathy, characterized by progressive distal hypoesthesia and amyotrophia. CMT is characterized by an X- linked recessive inheritance pattern. The...
Citation: Hereditas 2023 160:22 -
A potential immunotherapeutic and prognostic biomarker for multiple tumors including glioma: SHOX2
Short stature homeobox 2 (SHOX2) is significant gene in the development and progression of multiple types of tumors. Nonetheless, the biological role of SHOX2 within pan-cancer datasets has not been investigat...
Citation: Hereditas 2023 160:21 -
Genomics in animal breeding from the perspectives of matrices and molecules
This paper describes genomics from two perspectives that are in use in animal breeding and genetics: a statistical perspective concentrating on models for estimating breeding values, and a sequence perspective...
Citation: Hereditas 2023 160:20 -
Stable populations and Hardy-Weinberg equilibrium
The conditions on the mating matrix associated with a stable equilibrium are specified for an autosomal locus with five alleles. This points the way to the maintenance of Hardy-Weinberg proportions with non-ra...
Citation: Hereditas 2023 160:19 -
Deciphering the potential ability of RG108 in cisplatin-induced HEI-OC1 ototoxicity: a research based on RNA-seq and molecular biology experiment
Drug-induced hearing loss (DIHL) is very common, and seriously affects people's happiness in life. RG108 is a small molecule inhibitor. RG108 is protective against DIHL. Our purpose is to probe the incidence o...
Citation: Hereditas 2023 160:18 -
Identification and validation of autophagy-related genes in Kawasaki disease
Kawasaki disease (KD) is a systemic vasculitis of unknown etiology affecting mainly children. Studies have shown that the pathogenesis of KD may be related to autophagy. Using bioinformatics analysis, we asses...
Citation: Hereditas 2023 160:17 -
Mendel’s terminology and notation reveal his understanding of genetics
We describe both the terminology and use of symbols introduced by Mendel in his 1866 paper and discuss some misconceptions concerning their interpretation.
Citation: Hereditas 2023 160:16 -
γ-tocotrienol regulates gastric cancer by targeting notch signaling pathway
Gastric cancer is a common cause of death from cancer and an important global health care issue. Consequently, there is an urgent need to find new drugs and therapeutic targets for the treatment of gastric can...
Citation: Hereditas 2023 160:15 -
Comprehensive evaluations of individual discrimination, kinship analysis, genetic relationship exploration and biogeographic origin prediction in Chinese Dongxiang group by a 60-plex DIP panel
Dongxiang group, as an important minority, resides in Gansu province which is located at the northwest China, forensic detection system with more loci needed to be studied to improve the application efficiency...
Citation: Hereditas 2023 160:14 -
CCNE1 is a predictive and immunotherapeutic indicator in various cancers including UCEC: a pan-cancer analysis
CCNE1 plays an important oncogenic role in several tumors, especially high-stage serous ovarian cancer and endometrial cancer. Nevertheless, the fundamental function of CCNE1 has not been explored in multiple ...
Citation: Hereditas 2023 160:13 -
Circular RNA circHMCU promotes breast tumorigenesis through miR-4458/PGK1 regulatory cascade
Circular RNAs (circRNAs) are abnormally expressed in breast cancer (BC). However, the biological function and mechanism of circHMCU still need to be further explored.
Citation: Hereditas 2023 160:12 -
SMPD1 expression profile and mutation landscape help decipher genotype–phenotype association and precision diagnosis for acid sphingomyelinase deficiency
Acid sphingomyelinase deficiency (ASMD) disorder, also known as Niemann–Pick disease (NPD) is a rare genetic disease caused by mutations in SMPD1 gene, which encodes sphingomyelin phosphodiesterase (ASM). Except ...
Citation: Hereditas 2023 160:11 -
Development and validation of an RBP gene signature for prognosis prediction in colorectal cancer based on WGCNA
RNA binding proteins (RBPs) have been implicated in oncogenesis and progression in various cancers. However, the potential value of RBPs as prognostic indicators and therapeutic targets in colorectal cancer (C...
Citation: Hereditas 2023 160:10 -
Identification of the shared genes and immune signatures between systemic lupus erythematosus and idiopathic pulmonary fibrosis
Systemic lupus erythematosus (SLE) is an autoimmune disorder which could lead to inflammation and fibrosis in various organs. Pulmonary fibrosis is a severe complication in patients with SLE. Nonetheless, SLE-...
Citation: Hereditas 2023 160:9 -
Identification of autophagy-related genes in neuropathic pain through bioinformatic analysis
Neuropathic pain (NP) is one of the most common types of chronic pain and significantly compromises the quality of life. Autophagy is an intracellular catabolic process that is required to maintain cellular ho...
Citation: Hereditas 2023 160:8 -
Exploration of the underlying comorbidity mechanism in psoriasis and periodontitis: a bioinformatics analysis
Increasing evidence indicates that psoriasis (PSO) and periodontitis (PD) are likely to occur together, however, the underlying mechanism remains unclear.
Citation: Hereditas 2023 160:7 -
m6A-related lncRNA-based immune infiltration characteristic analysis and prognostic model for colonic adenocarcinoma
Colonic adenocarcinoma (COAD) is a common gastrointestinal tract tumor, and its occurrence and progression are typically associated with genomic instability, tumor-suppressor gene and oncogene mutations, and t...
Citation: Hereditas 2023 160:6 -
Understanding the contemporary high obesity rate from an evolutionary genetic perspective
The topic of obesity is gaining increasing popularity globally. From an evolutionary genetic perspective, it is believed that the main cause of the high obesity rate is the mismatch between environment and gen...
Citation: Hereditas 2023 160:5 -
Development of a risk model based on autophagy-related genes to predict survival and immunotherapy response in ovarian cancer
Autophagy is a highly conserved cellular proteolytic process that can interact with innate immune signaling pathways to affect the growth of tumor cells. However, the regulatory mechanism of autophagy in the t...
Citation: Hereditas 2023 160:4 -
Forkhead box P3 gene polymorphisms predispose to type 2 diabetes and diabetic nephropathy in the Han Chinese populations: a genetic-association and gender-based evaluation study
Functional mutations or polymorphisms affecting forkhead box P3 (FOXP3) can lead to their abnormal FOXP3 gene expression and/or defective Treg cells generation, thus resulting in autoimmune disease and inflammato...
Citation: Hereditas 2023 160:3
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