Articles

Common founder effects of hereditary hemochromatosis, Wilson´s disease, the long QT syndrome and autosomal recessive deafness caused by two novel mutations in the WHRN and TMC1 genes

Genealogy and molecular genetic studies of a Swedish river valley population resulted in a large pedigree, showing that the hereditary hemochromatosis (HH) HFE/p.C282Y mutation is inherited with other recessive d...

Authors: K. Sigvard Olsson, Olof Wålinder, Ulf Jansson, Maria Wilbe, Marie-Louise Bondeson, Eva-Lena Stattin, Ruma Raha-Chowdhury and Roger Williams

Hybrid identification and genetic variation of Elymus sibiricus hybrid populations using EST-SSR markers

Elymus sibiricus is an important native grass in Qinghai-Tibetan Plateau. Seed shattering is a serious problem for E. sibiricus, especially at harvest time. Cross breeding is an effect...

Authors: Xuhong Zhao, Junchao Zhang, Zongyu Zhang, Yanrong Wang and Wengang Xie

Switchgrass PvDREB1C plays opposite roles in plant cold and salt tolerance in transgenic tobacco

The C-repeat-binding factors/DRE-binding factors (CBF/DREBs) comprise a key transcription factor family involved in plant stress tolerance. Yet, there is limited information about switchgrass DREB genes and th...

Authors: Wuwu Wen, Zheni Xie, Guohui Yu, Chengliang Zhao, Jing Zhang, Linkai Huang, Bin Xu and Bingru Huang

Characterizing the transcriptome and microsatellite markers for almond (Amygdalus communis L.) using the Illumina sequencing platform

The almond tree (Prunus amygdalus Batsch) is an important nut tree grown in subtropical regions that produces nutrient-rich nuts. However, a paucity of genomic information and DNA markers has restricted the devel...

Authors: Linsen Zhang, Xiaoni Yang, Xiangning Qi, Chunhui Guo and Zhaobin Jing

Regulatory pathway analysis of coat color genes in Mongolian horses

Studies on the molecular genetics of horse skin pigmentation have typically focused on very few genes and proteins. In this study, we used Illumina sequencing to determine the global gene expression profiles i...

Authors: Bei Li, Xiaolong He, Yiping Zhao, Dongyi Bai, Wunierfu Shiraigo, Qinan Zhao and Dugarjaviin Manglai

Drosophila exoribonuclease nibbler is a tumor suppressor, acts within the RNAⁱ machinery and is not enriched in the nuage during early oogenesis

micro RNAs (miRNAs) are important regulators of many biological pathways. A plethora of steps are required to form, from a precursor, the mature miRNA that eventually acts on its target RNA to repress its expr...

Authors: Casimiro Castillejo-López, Xiaoli Cai, Khalid Fahmy and Stefan Baumgartner

Identification of candidate genes involved in the sugar metabolism and accumulation during pear fruit post-harvest ripening of ‘Red Clapp’s Favorite’ (Pyrus communis L.) by transcriptome analysis

Pear (Pyrus spp.) is a popular fruit that is commercially cultivated in most temperate regions. In fruits, sugar metabolism and accumulation are important factors for fruit organoleptic quality. Post-harvest ripe...

Authors: Long Wang, Yun Chen, Suke Wang, Huabai Xue, Yanli Su, Jian Yang and Xiugen Li

Mutations in the gene of the Gα subunit of the heterotrimeric G protein are the cause for the brachytic1 semi-dwarf phenotype in barley and applicable for practical breeding

Short-culm mutants have been widely used in breeding programs to increase lodging resistance. In barley (Hordeum vulgare L.), several hundreds of short-culm mutants have been isolated over the years. The objectiv...

Authors: Ilka Braumann, Christoph Dockter, Sebastian Beier, Axel Himmelbach, Finn Lok, Udda Lundqvist, Birgitte Skadhauge, Nils Stein, Shakhira Zakhrabekova, Ruonan Zhou and Mats Hansson

MiRNAs of peripheral blood as the biomarker of schizophrenia

The diagnosis of schizophrenia is currently based on the symptoms and bodily signs rather than on the pathological and physiological markers of the patient. In the search for new molecular targeted therapy med...

Authors: Kuanjun He, Chuang Guo, Lin He and Yongyong Shi

Genotypic and phenotypic evaluation of off-type grasses in hybrid Bermudagrass [Cynodon dactylon (L.) Pers. x C. transvaalensis Burtt-Davy] putting greens using genotyping-by-sequencing and morphological characterization

Interspecific hybrid bermudagrass [Cynodon dactylon (L.) Pers. x C. transvaalensis Burtt-Davy] is one of the most widely used grasses on golf courses, with cultivars derived from ‘Tifgreen’ or ‘Tifdwarf’ particul...

Authors: Eric H. Reasor, James T. Brosnan, Margaret E. Staton, Thomas Lane, Robert N. Trigiano, Phillip A. Wadl, Joann A. Conner and Brian M. Schwartz

Human genetics in troubled times and places

The development of human genetics world-wide during the twentieth century, especially across Europe, has occurred against a background of repeated catastrophes, including two world wars and the ideological pro...

Authors: Peter S. Harper

SSR marker variations in Brassica species provide insight into the origin and evolution of Brassica amphidiploids

Oilseed Brassica represents an important group of oilseed crops with a long history of evolution and cultivation. To understand the origin and evolution of Brassica amphidiploids, simple sequence repeat (SSR) ...

Authors: Ajay Kumar Thakur, Kunwar Harendra Singh, Lal Singh, Joghee Nanjundan, Yasin Jeshima Khan and Dhiraj Singh

Genetic risk between the CACNA1I gene and schizophrenia in Chinese Uygur population

Schizophrenia (SCZ) is a common mental disorder with high heritability, and genetic factors play a major role in the pathogenesis. Recent researches indicated that the CACNA1I involved in calcium channels probabl...

Authors: Wei Xu, Yahui Liu, Jianhua Chen, Qingli Guo, Ke Liu, Zujia Wen, Zhaowei Zhou, Zhijian Song, Juan Zhou, Lin He, Qizhong Yi and Yongyong Shi

Microarray study of gene expression profile to identify new candidate genes involved in the molecular mechanism of leptin-induced knee joint osteoarthritis in rat

Osteoarthritis (OA) is one of the most prevalent chronic joint diseases while the precise genetic mechanism remains elusive. In this study, we investigated the gene expression profile in OA by microarray analy...

Authors: Qing Fan, Zhu Liu, Chao Shen, Hai Li, Jing Ding, Fangchun Jin, Lin Sha and Ziming Zhang

Genetic diversity and structure of core collection of winter mushroom (Flammulina velutipes) developed by genomic SSR markers

A core collection is a subset of an entire collection that represents as much of the genetic diversity of the entire collection as possible. The establishment of a core collection for crops is practical for ef...

Authors: Xiao Bin Liu, Jing Li and Zhu L. Yang

Identity-by-descent refines mapping of candidate regions for preaxial polydactyly II /III in a large Chinese pedigree

Preaxial polydactyly (PPD) is congenital hand malformation characterized by the duplication of digit. Herein, we scan the genome-wide SNPs for a large Chinese family with PPD-II/III. We employ the refined IBD ...

Authors: Xingyan Yang, Quankuan Shen, Xierzhatijiang Sulaiman, Hequn Liu, Minsheng Peng and Yaping Zhang

Adaptation of human skin color in various populations

Skin color is a well-recognized adaptive trait and has been studied extensively in humans. Understanding the genetic basis of adaptation of skin color in various populations has many implications in human evol...

Authors: Lian Deng and Shuhua Xu

A systematic review of rye (Secale cereale L.) as a source of resistance to pathogens and pests in wheat (Triticum aestivum L.)

Wheat is globally one of the most important crops. With the current human population growth rate, there is an increasing need to raise wheat productivity by means of plant breeding, along with development of m...

Authors: Leonardo A. Crespo-Herrera, Larisa Garkava-Gustavsson and Inger Åhman

Microdissection of the A_h01 chromosome in upland cotton and microcloning of resistance gene anologs from the single chromosome

Chromosome microdissection is one of the most important techniques in molecular cytogenetic research. Cotton (Gossypium Linnaeus, 1753) is the main natural fiber crop in the world. The resistance gene analog (RGA...

Authors: Xinchuan Cao, Yuling Liu, Zhen Liu, Fang Liu, Yalei Wu, Zhongli Zhou, Xiaoyan Cai, Xingxing Wang, Zhenmei Zhang, Yuhong Wang, Zhimin Luo, Renhai Peng and Kunbo Wang

A comparative genomics approach revealed evolutionary dynamics of microsatellite imperfection and conservation in genus Gossypium

Ongoing molecular processes in a cell could target microsatellites, a kind of repetitive DNA, owing to length variations and motif imperfection. Mutational mechanisms underlying such kind of genetic variations...

Authors: Muhammad Mahmood Ahmed, Chao Shen, Anam Qadir Khan, Muhammad Atif Wahid, Muhammad Shaban and Zhongxu Lin

Contrasting patterns of nucleotide polymorphism suggest different selective regimes within different parts of the PgiC1 gene in Festuca ovina L.

Phosphoglucose isomerase (PGI, EC 5.3.1.9) is an essential metabolic enzyme in all eukaryotes. An earlier study of the PgiC1 gene, which encodes cytosolic PGI in the grass Festuca ovina L., revealed a marked diff...

Authors: Yuan Li, Bengt Hansson, Lena Ghatnekar and Honor C. Prentice

Analysis of differentially expressed genes and adaptive mechanisms of Prunus triloba Lindl. under alkaline stress

Prunus triloba Lindl. is a naturally salt-alkaline-tolerant plant with several unique characteristics, and it can be used as the rootstock of Chinese plum (Prunus salicina Lindl.) in s...

Authors: Jia Liu, Yongqing Wang and Qingtian Li

Genetic diversity and population structure analysis of Kala bhat (Glycine max (L.) Merrill) genotypes using SSR markers

Kala bhat (Black soybean) is an important legume crop in Uttarakhand state, India, due to its nutritional and medicinal properties. In the current study, the genetic variabilities present in Kala bhat were est...

Authors: Yegappa Hipparagi, Rakesh Singh, Debjani Roy Choudhury and Veena Gupta

Ancient role of ten-m/odz in segmentation and the transition from sequential to syncytial segmentation

Until recently, mechanisms of segmentation established for Drosophila served as a paradigm for arthropod segmentation. However, with the discovery of gene expression waves in vertebrate segmentation, another para...

Authors: Axel Hunding and Stefan Baumgartner

The complete mitogenome of Orcula dolium (Draparnaud, 1801); ultra-deep sequencing from a single long-range PCR using the Ion-Torrent PGM

With the increasing capacity of present-day next-generation sequencers the field of mitogenomics is rapidly changing. Enrichment of the mitochondrial fraction, is no longer necessary for obtaining mitogenomic ...

Authors: D. S. J. Groenenberg, J. Harl, E. Duijm and E. Gittenberger

Psychomotor retardation with a 1q42.11–q42.12 deletion

A 1q42 deletion is a rare structure variation that commonly harbours various deletion breakpoints along with diversified phenotypes. In our study, we found a de novo 1q42 deletion in a boy who did not have a clef...

Authors: Jialing He, Yingjun Xie, Shu Kong, Wenjun Qiu, Xiaoman Wang, Ding Wang, Xiaofang Sun and Deming Sun

Genome-wide association study of rust traits in orchardgrass using SLAF-seq technology

While orchardgrass (Dactylis glomerata L.) is a well-known perennial forage species, rust diseases cause serious reductions in the yield and quality of orchardgrass; however, genetic mechanisms of rust resistance...

Authors: Bing Zeng, Haidong Yan, Xinchun Liu, Wenjing Zang, Ailing Zhang, Sifan Zhou, Linkai Huang and Jinping Liu

Estimation of genetic diversity in Gute sheep: pedigree and microsatellite analyses of an ancient Swedish breed

Breeds with small population size are in danger of an increased inbreeding rate and loss of genetic diversity, which puts them at risk for extinction. In Sweden there are a number of local breeds, native breed...

Authors: Christina M. Rochus and Anna M. Johansson

PCR-based assays for validation of single nucleotide polymorphism markers in rice and mungbean

Single nucleotide polymorphism (SNP) markers are the method of choice for genetic analyses including diversity and quantitative trait loci (QTL) studies. Marker validation is essential for QTL studies, but the...

Authors: Thu Giang Thi Bui, Nguyen Thi Lan Hoa, Jo-yi Yen and Roland Schafleitner

A replication study of schizophrenia-related rare copy number variations in a Han Southern Chinese population

Schizophrenia (SCZ) is a common, complex and severe psychiatric disorder associated with many different genetic and environmental risk factors. Evidence from genetic studies has revealed the role of genome str...

Authors: Jianmin Yuan, Jianlin Hu, Zhiqiang Li, Fuquan Zhang, Dexiang Zhou and Chunhui Jin

Molecular breeding of a novel orange-brown tomato fruit with enhanced beta-carotene and chlorophyll accumulation

Tomatoes provide a significant dietary source of the carotenoids, lycopene and β-carotene. During ripening, carotenoid accumulation determines the fruit colors while chlorophyll degradation. These traits have ...

Authors: Ranjith Kumar Manoharan, Hee-Jeong Jung, Indeok Hwang, Namhee Jeong, Kang Hee Kho, Mi-Young Chung and Ill-Sup Nou

Transcriptome analysis of genes involved in anthocyanins biosynthesis and transport in berries of black and white spine grapes (Vitis davidii)

The color of berry skin is an important economic trait for grape and is essentially determined by the components and content of anthocyanins. The fruit color of Chinese wild grapes is generally black, and the ...

Authors: Lei Sun, Xiucai Fan, Ying Zhang, Jianfu Jiang, Haisheng Sun and Chonghuai Liu

PineElm_SSRdb: a microsatellite marker database identified from genomic, chloroplast, mitochondrial and EST sequences of pineapple (Ananas comosus (L.) Merrill)

Simple Sequence Repeats or microsatellites are resourceful molecular genetic markers. There are only few reports of SSR identification and development in pineapple. Complete genome sequence of pineapple availa...

Authors: Sakshi Chaudhary, Bharat Kumar Mishra, Thiruvettai Vivek, Santoshkumar Magadum and Jeshima Khan Yasin

Negative frequency dependent selection on sympatric mtDNA haplotypes in Drosophila subobscura

Recent experimental evidence for selection on mitochondrial DNA (mtDNA) has prompted the question as to what processes act to maintain within-population variation in mtDNA. Balancing selection though negative ...

Authors: Göran Arnqvist, Zorana Kurbalija Novičić, José A. Castro and Ahmed Sayadi

A C-banded karyotype of mitotic chromosomes in diploid purple coneflower (Echinacea purpurea L.)

Aneuploid ermpglasm is an important resource for genetic studies and identification of individual chromosomes in the cells of the aneuploid is an important step. The karyotype has already been established for ...

Authors: Weizhen Jiang, Qingling Li, Xiaolu Chen, Yi Ren, Rong Chen, Hong Wu and Yuesheng Yang

Effect on the expression of drd2 and drd3 after neonatal lesion in the lymphocytes, nucleus accumbens, hippocampus and prefrontal cortex: comparative analysis between juvenile and adult Wistar rats

Neonatal lesion in the ventral hippocampus (NLVH) is a validated animal model to study schizophrenia from a neurodevelopmental perspective. This animal model is also used to investigate how neonatal lesions ma...

Authors: Alma Delia Genis-Mendoza, Carlos Alfonso Tovilla-Zárate, Lilia López-Narvaez, Patricia Mendoza-Lorenzo, Patricia Ostrosky-Wegman, Humberto Nicolini, Thelma Beatriz González-Castro and Yazmin Hernández-Diaz

Efficient callus formation and plant regeneration are heritable characters in sugar beet (Beta vulgaris L.)

Obtaining dedifferentiated cells (callus) that can regenerate into whole plants is not always feasible for many plant species. Sugar beet is known to be recalcitrant for dedifferentiation and plant regeneratio...

Authors: Hiroyo Kagami, Kazunori Taguchi, Takumi Arakawa, Yosuke Kuroda, Hideto Tamagake and Tomohiko Kubo

Whole genome SNP typing to investigate methicillin-resistant Staphylococcus aureus carriage in a health-care provider as the source of multiple surgical site infections

Prevention of nosocomial transmission of infections is a central responsibility in the healthcare environment, and accurate identification of transmission events presents the first challenge. Phylogenetic anal...

Authors: Chandler C. Roe, Kimberly S. Horn, Elizabeth M. Driebe, Jolene Bowers, Joel A. Terriquez, Paul Keim and David M. Engelthaler

Genetic diversity and occurrence of the F129L substitutions among isolates of Alternaria solani in south-eastern Sweden

Early blight, caused by the fungus Alternaria solani, occurs on potato mainly in the south-eastern part of Sweden, but also in other parts of the country. The aim of this study was to investigate the genetic dive...

Authors: Firuz Odilbekov, Eva Edin, Larisa Garkava-Gustavsson, Helena Persson Hovmalm and Erland Liljeroth

Insight into the genetic variability analysis and cultivar identification of tall fescue by using SSR markers

Genetic diversity of 19 forage-type and 2 turf-type cultivars of tall fescue (Festuca arundinacea Schreb.) was revealed using SSR markers in an attempt to explore the genetic relationships among them, and examine...

Authors: Kaixin Fu, Zhihui Guo, Xinquan Zhang, Yan Fan, Wendan Wu, Daxu Li, Yan Peng, Linkai Huang, Ming Sun, Shiqie Bai and Xiao Ma

Genetic structure of Mount Huang honey bee (Apis cerana) populations: evidence from microsatellite polymorphism

The Mount Huang eastern honey bees (Apis cerana) are an endemic population, which is well adapted to the local agricultural and ecological environment. In this study, the genetic structure of seven eastern honey ...

Authors: Fang Liu, Tengfei Shi, Sisi Huang, Linsheng Yu and Shoudong Bi

Assessment of diversity and genetic relationships of Neonectria ditissima: the causal agent of fruit tree canker

Neonectria ditissima is one of the most important fungal pathogens of apple trees, where it causes fruit tree canker. Information about the amount and partitioning of genetic variation...

Authors: Marjan Ghasemkhani, Larisa Garkava-Gustavsson, Erland Liljeroth and Hilde Nybom

eRFSVM: a hybrid classifier to predict enhancers-integrating random forests with support vector machines

Enhancers are tissue specific distal regulation elements, playing vital roles in gene regulation and expression. The prediction and identification of enhancers are important but challenging issues for bioinfor...

Authors: Fang Huang, Jiawei Shen, Qingli Guo and Yongyong Shi

Assessment of genetic diversity in Nordic timothy (Phleum pratense L.)

Timothy (Phleum pratense L.), a cool-season hexaploid perennial, is the most important forage grass species in Nordic countries. Earlier analyses of genetic diversity in a collection of 96 genebank accessions of ...

Authors: Pirjo Tanhuanpää, Maria Erkkilä, Ruslan Kalendar, Alan Howard Schulman and Outi Manninen

Genetic variation, population structure and linkage disequilibrium in Switchgrass with ISSR, SCoT and EST-SSR markers

To evaluate genetic variation, population structure, and the extent of linkage disequilibrium (LD), 134 switchgrass (Panicum virgatum L.) samples were analyzed with 51 markers, including 16 ISSRs, 20 SCoTs, and 1...

Authors: Yu Zhang, Haidong Yan, Xiaomei Jiang, Xiaoli Wang, Linkai Huang, Bin Xu, Xinquan Zhang and Lexin Zhang

Cloning and characterization of an ABA-independent DREB transcription factor gene, HcDREB2, in Hemarthria compressa

Hemarthria compressa is a stoloniferous perennial tropical forage grass with a wide geographic distribution; however, environmental stress has a great influence on its growth. The DREB...

Authors: Yongxia Chen, Linkai Huang, Haidong Yan, Xinquan Zhang, Bin Xu and Xiao Ma

Leptin receptor gene polymorphisms and morbid obesity in Mexican patients

Human obesity is due to a complex interaction among environmental, behavioral, developmental and genetic factors, including the interaction of leptin (LEP) and leptin receptor (LEPR). Several LEPR mutations and p...

Authors: Martin Edgardo Rojano-Rodriguez, Jose Luis Beristain-Hernandez, Beatriz Zavaleta-Villa, Pablo Maravilla, Mirza Romero-Valdovinos and Angelica Olivo-Diaz

A preliminary phylogeny of the South African Lentulidae

The grasshopper family Lentulidae is endemic to eastern and southern Africa, with its center of diversity situated in South Africa, the highest diversity being found in the Cape Floristic Region, which is one ...

Authors: Daniela Matenaar, Linda Bröder and Axel Hochkirch

Resurrection of Hereditas, a journal with almost 100 years of tradition

Authors: Stefan Baumgartner

Analysis of genetic diversity of Tunisian caprifig (Ficus carica L.) accessions using simple sequence repeat (SSR) markers

The common fig (Ficus carica L.) is a gynodioecious species with two sexual forms: male trees (caprifigs) with male and female flowers and female trees that produce only female flowers that will result in the edi...

Authors: Awatef Essid, Fateh Aljane, Ali Ferchichi and Jose Ignacio Hormaza