The Mendelian Society of Lund has been publishing the journal Hereditas since 1920.
Articles
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Citation: Hereditas 2021 158:19
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Somatic frameshift mutation in PIK3CA causes CLOVES syndrome by provoking PI3K/AKT/mTOR pathway
CLOVES syndrome (OMIM# 612918) is a rare overgrowth disorder resulted from mosaic gain-of-function mutations in the PIK3CA gene. All the reported CLOVES-associated PIK3CA mutations are missense mutations affectin...
Citation: Hereditas 2021 158:18 -
Up-regulated RFC2 predicts unfavorable progression in hepatocellular carcinoma
Replication factor C (RFC) is closely related to tumor progression and metastasis. However, the functional significance of RFC2 in hepatocellular carcinoma remains unclear.
Citation: Hereditas 2021 158:17 -
Association between CCN1 gene polymorphism and acute coronary syndrome in Chinese Han and Uygur populations
CCN1 plays a crucial role in the modulation of cardiovascular diseases. However, whether CCN1 genetic variants are involved in the susceptibility of ACS remains unknown. Hence, the present study investigates the ...
Citation: Hereditas 2021 158:16 -
Prognostic biomarkers and therapeutic targets in oral squamous cell carcinoma: a study based on cross-database analysis
Oral squamous cell carcinoma (OSCC) is a malignant cancer, the survival rate of patients is disappointing. Therefore, it is necessary to identify the driven-genes and prognostic biomarkers in OSCC.
Citation: Hereditas 2021 158:15 -
Identification of metabolism genes related to hepatocarcinogenesis and progression in type 2 diabetes mellitus via co-expression networks analysis
Type 2 Diabetes Mellitus (T2DM) is an independent risk factor of hepatocellular carcinoma (HCC). However, the related genes and modules to hepatocarcinogenesis and progression in T2DM remain unclear.
Citation: Hereditas 2021 158:14 -
Bioinformatic analysis identifies potential biomarkers and therapeutic targets of septic-shock-associated acute kidney injury
Sepsis and septic shock are life-threatening diseases with high mortality rate in intensive care unit (ICU). Acute kidney injury (AKI) is a common complication of sepsis, and its occurrence is a poor prognosti...
Citation: Hereditas 2021 158:13 -
Genetic polymorphism of IDOL gene was associated with the susceptibility of coronary artery disease in Han population in Xinjiang, China
Coronary artery disease (CAD) is the leading cause of death worldwide. In this study, we aimed to explore whether some genetic variants of the human IDOL gene were associated with CAD among Chinese population ...
Citation: Hereditas 2021 158:12 -
Nucleo-cytoplasmic shuttling of murine RBPJ by Hairless protein matches that of Su(H) protein in the model system Drosophila melanogaster
CSL transcription factors are central to signal transduction in the highly conserved Notch signaling pathway. CSL acts as a molecular switch: depending on the cofactors recruited, CSL induces either activation...
Citation: Hereditas 2021 158:11 -
Performance comparison of four types of target enrichment baits for exome DNA sequencing
Next-generation sequencing technology is developing rapidly and target capture sequencing has become an important technique. Several different platforms for library preparation and target capture with differen...
Citation: Hereditas 2021 158:10 -
Development and analysis of long non-coding RNA-associated competing endogenous RNA network for osteosarcoma metastasis
Osteosarcoma is the primary bone malignant neoplasm that often develops metastasis. Increasing evidences have shown that non-coding RNAs (ncRNAs) relate to the progression of osteosarcoma. However, the ncRNAs’...
Citation: Hereditas 2021 158:9 -
Correction to: A century of Hereditas: from local publication to international journal
An amendment to this paper has been published and can be accessed via the original article.
Citation: Hereditas 2021 158:8 -
PeakMatcher facilitates updated Aedes aegypti embryonic cis-regulatory element map
The Aedes aegypti mosquito is a threat to human health across the globe. The A. aegypti genome was recently re-sequenced and re-assembled. Due to a combination of long-read PacBio and Hi-C sequencing, the AaegL5 ...
Citation: Hereditas 2021 158:7 -
A novel intron mutation in FBN-1 gene identified in a pregnant woman with Marfan syndrome
Marfan syndrome (MFS) is one of the most common hereditary connective tissue diseases, with great individual heterogeneity. We reported a Chinese pregnancy with Clinical diagnosis of MFS, performed whole-exome...
Citation: Hereditas 2021 158:6 -
Identification of differentially expressed genes, signaling pathways and immune infiltration in rheumatoid arthritis by integrated bioinformatics analysis
The disability rate associated with rheumatoid arthritis (RA) ranks high among inflammatory joint diseases. However, the cause and potential molecular events are as yet not clear. Here, we aimed to identify di...
Citation: Hereditas 2021 158:5 -
Mediators of SARS-CoV-2 entry are preferentially enriched in cardiomyocytes
The coronavirus disease 2019 (COVID-19) has spread rapidly around the world. In addition to common respiratory symptoms such as cough and fever, some patients also have cardiac injury, however, the mechanism o...
Citation: Hereditas 2021 158:4 -
IFI27 may predict and evaluate the severity of respiratory syncytial virus infection in preterm infants
Preterm infants are a special population that vulnerable to respiratory syncytial virus (RSV) infection and the lower respiratory tract infections (LRTIs) caused by RSV could be severe and even life-threating....
Citation: Hereditas 2021 158:3 -
Immunological analysis and differential genes screening of venous thromboembolism
To explore the pathogenesis of venous thromboembolism (VTE) and provide bioinformatics basis for the prevention and treatment of VTE.
Citation: Hereditas 2021 158:2 -
Defining muscle-invasive bladder cancer immunotypes by introducing tumor mutation burden, CD8+ T cells, and molecular subtypes
Immunotherapy, especially anti-PD-1, is becoming a pillar of modern muscle-invasive bladder cancer (MIBC) treatment. However, the objective response rates (ORR) are relatively low due to the lack of precise bi...
Citation: Hereditas 2021 158:1 -
The reversal of human phylogeny: Homo left Africa as erectus, came back as sapiens sapiens
The molecular out of Africa hypothesis, OOAH, has been considered as an established fact amid population geneticists for some 25–30 years despite the early concern with it among phylogeneticists with experienc...
Citation: Hereditas 2020 157:51 -
A century of Hereditas: from local publication to international journal
The Mendelian Society of Lund launched Hereditas in 1920. The purpose of this article is to give an overview of Hereditas’s hundred-year existence, focusing on the conditions for a learned society to publish a sc...
Citation: Hereditas 2020 157:50 -
Population genomics of East Asian ethnic groups
East Asia constitutes one-fifth of the global population and exhibits substantial genetic diversity. However, genetic investigations on populations in this region have been largely under-represented compared w...
Citation: Hereditas 2020 157:49 -
Race biology
The founders of Hereditas envisioned that race biology would be a major subject that had social applications with utmost importance in the near future. Anthropometrics was in this context understood to be the ...
Citation: Hereditas 2020 157:48 -
Two novel likely pathogenic variants of HARS2 identified in a Chinese family with sensorineural hearing loss
Mutations in HARS2 are one of the genetic causes of Perrault syndrome, characterized by sensorineural hearing loss (SNHL) and ovarian dysfunction. Here, we identified two novel putative pathogenic variants of HAR...
Citation: Hereditas 2020 157:47 -
The homeodomain transcription factor Orthopedia is involved in development of the Drosophila hindgut
The Drosophila hindgut is commonly used model for studying various aspects of organogenesis like primordium establishment, further specification, patterning, and morphogenesis. During embryonic development of Dro...
Citation: Hereditas 2020 157:46 -
The centenary of Hereditas - almost a fairytale
This is the Editorial for a series of articles illuminating the history and success story of Hereditas, one of the oldest journals in the area of genetics. For this reason, we invite you to read this special s...
Citation: Hereditas 2020 157:45 -
Göte Turesson’s research legacy to Hereditas: from the ecotype concept in plants to the analysis of landraces’ diversity in crops
Hereditas began with articles on plants since its first issue in May 1920 (six out of eight) and continued with more original articles (43% of the total of this journal) on plants (of which 72% of those in plants...
Citation: Hereditas 2020 157:44 -
Exploring the mRNA expression level of RELN in peripheral blood of schizophrenia patients before and after antipsychotic treatment
The Reelin (RELN) gene encodes the protein reelin, which is a large extracellular matrix glycoprotein that plays a key role in brain development. Additionally, this protein may be involved in memory formation, ne...
Citation: Hereditas 2020 157:43 -
Weighted gene co-expression network analysis revealed key biomarkers associated with the diagnosis of hypertrophic cardiomyopathy
To reveal the molecular mechanism underlying the pathogenesis of HCM and find new effective therapeutic strategies using a systematic biological approach.
Citation: Hereditas 2020 157:42 -
Enhancer of mRNA Decapping protein 4 (EDC4) interacts with replication protein a (RPA) and contributes to Cisplatin resistance in cervical Cancer by alleviating DNA damage
Cervical cancer (CC) is the third most common gynecological malignancy around the world. Cisplatin is an effective drug, but cisplatin resistance is a vital factor limiting the clinical usage of cisplatin. Enh...
Citation: Hereditas 2020 157:41 -
Genetic diversity of avocado from the southern highlands of Tanzania as revealed by microsatellite markers
Avocado is an important cash crop in Tanzania, however its genetic diversity is not thoroughly investigated. This study was undertaken to explore the genetic diversity of avocado in the southern highlands usin...
Citation: Hereditas 2020 157:40 -
Comparative transcriptomic analysis of the tea plant (Camellia sinensis) reveals key genes involved in pistil deletion
The growth process of the tea plant (Camellia sinensis) includes vegetative growth and reproductive growth. The reproductive growth period is relatively long (approximately 1.5 years), during which a large number...
Citation: Hereditas 2020 157:39 -
A seven-gene signature model predicts overall survival in kidney renal clear cell carcinoma
Kidney renal clear cell carcinoma (KIRC) is a potentially fatal urogenital disease. It is a major cause of renal cell carcinoma and is often associated with late diagnosis and poor treatment outcomes. More evi...
Citation: Hereditas 2020 157:38 -
Microarray data analysis reveals gene expression changes in response to ionizing radiation in MCF7 human breast cancer cells
The aim of this study was to identify potential therapeutic target genes for breast cancer (BC) by the investigation of gene expression changes after ionizing radiation (IR) in BC cells. Gene expression profil...
Citation: Hereditas 2020 157:37 -
PP2A and tumor radiotherapy
Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase that serves as a key regulator of cellular physiology in the context of apoptosis, mitosis, and DNA damage responses. Canonically, PP2A functions...
Citation: Hereditas 2020 157:36 -
Novel genetic alteration in congenital melanocytic nevus: MAP2K1 germline mutation with BRAF somatic mutation
Congenital melanocytic nevus (CMN) represent a benign proliferative skin disease in the epidermis and dermis. CMN are historically known to be associated with activating NRAS or BRAF mutations. Melanoma freque...
Citation: Hereditas 2020 157:35 -
A recurrent mutation of GJB6 in a big Chinese family with Hidrotic ectodermal dysplasia
Hidrotic ectodermal dysplasia (HED) is a rare inherited syndrome characterised by nail dystrophy, palmoplantar hyperkeratosis and alopecia. Four mutations (p.G11R, p.A88V, p.V37E and p.D50N) in gap junction be...
Citation: Hereditas 2020 157:34 -
Association between polymorphisms in mannose-binding lectin 2 gene with pulmonary tuberculosis susceptibility
Mannose-binding lectin (MBL2) is considered to play a role in the human innate immune response to tuberculosis (TB) infections, and 4 common single nucleotide polymorphisms (SNPs) may be associated with pulmon...
Citation: Hereditas 2020 157:33 -
Identification of MMP1 as a potential gene conferring erlotinib resistance in non-small cell lung cancer based on bioinformatics analyses
Non-small cell lung cancer (NSCLC) is the major type of lung cancer with high morbidity and poor prognosis. Erlotinib, an inhibitor of epidermal growth factor receptor (EGFR), has been clinically applied for N...
Citation: Hereditas 2020 157:32 -
Re-testing reported significant SNPs related to suicide in a historical high -risk isolated population from north east India
Genetic diathesis of suicide is supported by family and twin studies. Few candidate gene pathways are known, but does not explain fully the complexity of suicide genetic risk. Recent investigations opting for ...
Citation: Hereditas 2020 157:31 -
Identification of candidate biomarkers and pathways associated with psoriasis using bioinformatics analysis
The aim of this study was to identify the candidate biomarkers and pathways associated with psoriasis. GSE13355 and GSE14905 were extracted from the Gene Expression Omnibus (GEO) database. Then the differentia...
Citation: Hereditas 2020 157:30 -
Identification of potential crucial genes and key pathways in osteosarcoma
The aim of this study is to identify the potential pathogenic and metastasis-related differentially expressed genes (DEGs) in osteosarcoma through bioinformatic analysis of Gene Expression Omnibus (GEO) database.
Citation: Hereditas 2020 157:29 -
miR-183-3p suppresses proliferation and migration of keratinocyte in psoriasis by inhibiting GAB1
MicroRNAs (miRNAs) target genes involved in the hyperproliferation of keratinocytes or immune dysfunction of psoriasis. This study prospectively determined the involvement of miR-183-3p in the pathogenesis of ...
Citation: Hereditas 2020 157:28 -
Unilateral and segmental distribution of facial erythema: is it a real port-wine stain?
Capillary malformation-arteriovenous malformations (CM-AVMs) caused by a RASA-1 or EPHB4 mutation are characterized as hereditary sporadic or multifocal capillary malformations (CMs), associated with potential...
Citation: Hereditas 2020 157:27 -
Common variants in LAMC1 confer risk for pelvic organ prolapse in Chinese population
Pelvic organ prolapse (POP) affects around 15% of postmenopausal women in China. Although it has been widely accepted that genetic variants could confer risk for POP, the genetic susceptibility variants remain...
Citation: Hereditas 2020 157:26 -
Aberrant expression for microRNA is potential crucial factors of haemorrhoid
Haemorrhoids occur commonly and frequently in the human digestive system. There are diverse causes of haemorrhoids and their in-depth pathogenesis is still currently unclear.
Citation: Hereditas 2020 157:25 -
Development of novel EST microsatellite markers for genetic diversity analysis and correlation analysis of velvet antler growth characteristics in Sika deer
Sika deer is one of the most popular and valued animals in China. However, few studies have been conducted on the microsatellite of Sika deer, which has hampered the progress of genetic selection breeding. To ...
Citation: Hereditas 2020 157:24 -
Identification of a 6-month-old baby with a combination of WAGR and Potocki-Shaffer contiguous deletion syndromes by SNP array testing
WAGR 11p13 deletion syndrome is associated with abnormalities including (W) ilms tumor, (A) niridia, (G) enitourinary abnormalities, and growth and mental (R) etardation (WAGR). Potocki–Schaffer syndrome is a ...
Citation: Hereditas 2020 157:23 -
Relationship between circulating miR-132 and non-alcoholic fatty liver disease in a Chinese population
Non-invasive diagnostic markers are of great importance for early screening nonalcoholic fatty liver disease (NAFLD). MicroRNAs (miRNAs) play significant roles in many metabolic disease, including NAFLD. There...
Citation: Hereditas 2020 157:22 -
Giant congenital melanocytic nevus of the scalp: from clinical-histological to molecular diagnosis
Congenital melanocytic nevus (CMN) is a benign proliferative skin disease in the epidermis and dermis. Large to giant CMNs are estimated to be associated with an increased lifetime risk of malignancy. It is ne...
Citation: Hereditas 2020 157:21
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