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Table 2 GO, KEGG and BIOCARTA analysis based on DAVID. (Down-DEGs between DMSO with CIS)

From: Deciphering the potential ability of RG108 in cisplatin-induced HEI-OC1 ototoxicity: a research based on RNA-seq and molecular biology experiment

GO

Category

Count

-Log2(P Value)

GOTERM_BP_DIRECT

GO:0030010 ~ establishment of cell polarity

6

4.84265555

GOTERM_BP_DIRECT

GO:0007420 ~ brain development

10

9.291692541

GOTERM_BP_DIRECT

GO:0030198 ~ extracellular matrix organization

8

8.723977207

GOTERM_BP_DIRECT

GO:0007399 ~ nervous system development

12

7.879202652

GOTERM_BP_DIRECT

GO:0007030 ~ Golgi organization

6

7.848307704

GOTERM_BP_DIRECT

GO:0015031 ~ protein transport

15

7.756581427

GOTERM_BP_DIRECT

GO:0016020 ~ membrane

100

17.7794164

GOTERM_BP_DIRECT

GO:0005737 ~ cytoplasm

105

16.41697626

GOTERM_BP_DIRECT

GO:0005794 ~ Golgi apparatus

31

13.40458113

GOTERM_BP_DIRECT

GO:0030315 ~ T-tubule

6

11.00613272

GOTERM_CC_DIRECT

GO:0043005 ~ neuron projection

15

8.74749388

GOTERM_CC_DIRECT

GO:0005856 ~ cytoskeleton

26

8.386444372

GOTERM_CC_DIRECT

GO:0000166 ~ nucleotide binding

33

11.0905486

GOTERM_CC_DIRECT

GO:0035091 ~ phosphatidylinositol binding

6

7.733881177

GOTERM_CC_DIRECT

GO:0005524 ~ ATP binding

27

7.467695552

GOTERM_CC_DIRECT

GO:0005085 ~ guanyl-nucleotide exchange factor activity

8

7.030604737

GOTERM_CC_DIRECT

GO:0051015 ~ actin filament binding

8

6.842845867

GOTERM_CC_DIRECT

GO:0004698 ~ calcium-dependent protein kinase C activity

3

6.508653954

GOTERM_CC_DIRECT

mmu04015:Rap1 signaling pathway

11

13.97604962

GOTERM_CC_DIRECT

mmu04360:Axon guidance

8

8.657491879

GOTERM_MF_DIRECT

mmu04730:Long-term depression

5

8.273286919

GOTERM_MF_DIRECT

mmu04925:Aldosterone synthesis and secretion

6

8.025647526

GOTERM_MF_DIRECT

mmu04510:Focal adhesion

8

7.819253967

GOTERM_MF_DIRECT

mmu04070:Phosphatidylinositol signaling system

5

5.905605906

GOTERM_MF_DIRECT

m_plcdPathway:Phospholipase C d1 in phospholipid associated cell signaling

2

4.333272899

GOTERM_MF_DIRECT

GO:0030010 ~ establishment of cell polarity

6

14.84265555

GOTERM_MF_DIRECT

GO:0007420 ~ brain development

10

9.291692541

GOTERM_MF_DIRECT

GO:0030198 ~ extracellular matrix organization

8

8.723977207

GOTERM_MF_DIRECT

GO:0007399 ~ nervous system development

12

7.879202652

GOTERM_MF_DIRECT

GO:0007030 ~ Golgi organization

6

7.848307704

KEGG_PATHWAY

GO:0015031 ~ protein transport

15

7.756581427

KEGG_PATHWAY

GO:0016020 ~ membrane

100

17.7794164

KEGG_PATHWAY

GO:0005737 ~ cytoplasm

105

16.41697626

KEGG_PATHWAY

GO:0005794 ~ Golgi apparatus

31

13.40458113

KEGG_PATHWAY

GO:0030315 ~ T-tubule

6

11.00613272

KEGG_PATHWAY

GO:0043005 ~ neuron projection

15

8.74749388

KEGG_PATHWAY

GO:0005856 ~ cytoskeleton

26

8.386444372

KEGG_PATHWAY

GO:0000166 ~ nucleotide binding

33

11.0905486

KEGG_PATHWAY

GO:0035091 ~ phosphatidylinositol binding

6

7.733881177

KEGG_PATHWAY

GO:0005524 ~ ATP binding

27

7.467695552

BIOCARTA

GO:0005085 ~ guanyl-nucleotide exchange factor activity

8

7.030604737