Fig. 1
Correlation and survival risk of m6A-associated prognostic lncRNAs with m6A regulators and expression in COAD and adjacent tissues. a Heat map of correlations between m6A regulators and 43 m6A-associated lncRNAs in TCGA data using one-way Cox regression analysis. The m6A-related prognostic lncRNAs were positively correlated with m6A regulators except RBM15B and ALKBH5, both of which showed a negative relationship with m6A-related prognostic lncRNA. b Survival risk ratios of 43 m6A-associated prognostic lncRNAs related to m6A in TCGA database were significantly associated with overall survival (OS) in patients with COAD; all of these lncRNAs were negatively associated with OS except for AL137782.1, AC073896.3, and AC104819.3. c and d Heat map (c) and box plot (d) showed that m6A methylation-related prognostic lncRNAs expression in COAD tumors and adjacent normal tissues by using Cancer Genome Map (TCGA) data to systematically examine the expression of 43 m6A methylation-related prognostic lncRNAs in COAD and its adjacent normal tissues. These lncRNAs were significantly differentially expressed in COAD and normal tissues, showing overall upregulated expression. e Differential expression of immune checkpoints in COAD and paracancerous normal tissue species. Comparison of eight common immune checkpoints in COAD tumors and paracancerous tissues revealed inconsistent expression patterns. *P < 0.05, **P < 0.01, ***P < 0.001. COAD, colon adenocarcinoma; lncRNA, long non-coding RNA; m6A: N6-methyladenosine