Table 3 KEGG analysis result of 22 enriched pathways

hsa04060

Cytokine-cytokine receptor interaction

34/155

295/8108

< 0.001

< 0.001

0.115

hsa04061

Viral protein interaction with cytokine and cytokine receptor

19/155

100/8108

< 0.001

< 0.001

0.190

hsa05340

Primary immunodeficiency

12/155

38/8108

< 0.001

< 0.001

0.316

hsa05332

Graft-versus-host disease

12/155

42/8108

< 0.001

< 0.001

0.286

hsa04659

Th17 cell differentiation

16/155

107/8108

< 0.001

< 0.001

0.149

hsa04612

Antigen processing and presentation

14/155

78/8108

< 0.001

< 0.001

0.179

hsa04650

Natural killer cell mediated cytotoxicity

16/155

131/8108

< 0.001

< 0.001

0.122

hsa04062

Chemokine signaling pathway

18/155

192/8108

< 0.001

< 0.001

0.094

hsa05321

Inflammatory bowel disease

11/155

65/8108

< 0.001

< 0.001

0.169

hsa04640

Hematopoietic cell lineage

12/155

99/8108

< 0.001

< 0.001

0.121

hsa04658

Th1 and Th2 cell differentiation

11/155

92/8108

< 0.001

< 0.001

0.119

hsa04514

Cell adhesion molecules

13/155

149/8108

< 0.001

< 0.001

0.087

hsa04660

T cell receptor signaling pathway

10/155

104/8108

< 0.001

< 0.001

0.096

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

9/155

89/8108

< 0.001

< 0.001

0.101

hsa05320

Autoimmune thyroid disease

7/155

53/8108

< 0.001

< 0.001

0.132

hsa05330

Allograft rejection

6/155

38/8108

< 0.001

< 0.001

0.158

hsa04940

Type I diabetes mellitus

6/155

43/8108

0.002

0.001

0.139

hsa05323

Rheumatoid arthritis

8/155

93/8108

0.004

0.003

0.086

hsa05143

African trypanosomiasis

5/155

37/8108

0.006

0.006

0.135

hsa04672

Intestinal immune network for IgA production

5/155

49/8108

0.022

0.019

0.102

hsa04630

JAK-STAT signaling pathway

9/155

162/8108

0.034

0.030

0.056

hsa05416

Viral myocarditis

5/155

60/8108

0.049

0.043

0.083