Forkhead box P3 gene polymorphisms predispose to type 2 diabetes and diabetic nephropathy in the Han Chinese populations: a genetic-association and gender-based evaluation study

Table 2 Genotype and allele frequency distribution of rs3761548C/A and rs2294021 Polymorphism among HC, T2DM and T2DN

		Genotype		χ2 (p-value)			Alleles	OR 95%CI	p-value	Group comparison	OR 95%CI	p-value
rs3761548		CC (%)	CA (%)	AA (%)		C	A
	HC (200)	145 (72.5)	37 (18.5)	18 (9)	10.452 (0.005)	0.82	0.18	0.625 (0.463–0.843)	0.002	CC vs. Others	0.530 (0.354–0.791)	0.002
	Patients (400)	269 (67)	56 (14)	75 (19)		0.74	0.26			CA vs Others	0.855 (0.533–1.370)	0.514
	Patients (400)	269 (67)	56 (14)	75 (19)		0.74	0.26			AA vs. Others	4.897 (2.398–10.003)	< 0.001
	T2DM (200)	144 (72)	38 (19)	18 (9)	28.765 (< 0.001)	0.815	0.185	0.461 (0.332–0.639)	< 0.001	CC vs. Others	0.648 (0.425–0.987)	0.043
	T2DN (200)	125 (62.5)	18 (9)	57 (28.5)		0.67	0.33			CA vs Others	0.422 (0.232–0.768)	0.005
	T2DN (200)	125 (62.5)	18 (9)	57 (28.5)		0.67	0.33			AA vs. Others	4.030 (2.272–7.151)	< 0.001
rs2294021		CC (%)	CT (%)	TT (%)		C	T
	HC (200)	82 (41)	55 (27.5)	63 (31.5)	10.672 (0.005)	0.55	0.45	0.826 (0.650–1.051)	0.121	CC vs. Others	1.021 (0.723–1.441)	0.907
	Patients (400)	166 (41.5)	68 (17)	166 (41.5)		0.50	0.50			CT vs Others	0.540 (0.360–0.810)	0.003
	Patients (400)	166 (41.5)	68 (17)	166 (41.5)		0.50	0.50			TT vs. Others	1.543 (1.078–2.208)	0.018
	T2DM (200)	89 (44.5)	44 (22)	67 (33.5)	12.918 (0.002)	0.55	0.45	0.643 (0.486–0.850)	0.002	CC vs. Others	0.781 (0.524–1.163)	0.224
	T2DN (200)	77 (38.5)	24 (12)	99 (49.5)		0.68	0.32			CT vs Others	0.483 (0.281–0.831)	0.009
	T2DN (200)	77 (38.5)	24 (12)	99 (49.5)		0.68	0.32			TT vs. Others	1.946 (1.299–2.914)	0.001

OR Odds Ratio and 95% CI, HC Healthy controls, T2DM Type 2 diabetes, T2DN Type 2 diabetic Nephropathy; patients = Female/Male (T2DN + T2DM)

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