Table 1 Regulation of certain hub genes in several functional pathways

Cell differentiation

Up

PPARG, CEBPA, FOXO1, LEP, LPL, SREBF1, FABP4, PPARGC1A, INSIG1, ZBTB16, MAFB, and SORT1

Down

IL6, CCND1, LEP, DDIT3, KLF4, PTGS2, WNT5A, PDGFRA, and TRIB3

Extracellular matrix organization

Up

-

Down

COL1A1, COL1A2, COL5A1, COL6A2, COL6A1, COL6A3, COL5A2, COL11A1, COL12A1, COL7A1, COL16A1, COL8A1, PLOD1, PLOD2, P4HB, COL13A1, P4HA2, COL22A1, P4HA1, and PLOD3

Angiogenesis development

Up

AKT1, GRB2, and MAP2K1

Down

GAPDH, HSP90AA1, MAPK3, VEGFA, FN1, JUN, HRAS, RHOA, CDC42, ITGB3, VCL, CCND1, STAT1, BCL2L1, RAF1, IQGAP1, and CSK