Fig. 2

a Gross appearence of a GCMN lesion in patient 1# during excision. b Hematoxylin-eosin staining of GCMN tissue from patient 1# (original magnification × 100). c Hematoxylin-eosin staining of adipose tissue in the deeper layers of the GCMN in patient 1# (original magnification × 400). d Gross appearence of a GCMN lesion in patient 2# during excision. e Hematoxylin-eosin staining of nPGCMN tissue of patient 2# (original magnification × 100). f Hematoxylin-eosin staining of dPGCMN tissue of patient 2# (original magnification × 100). g Hematoxylin-eosin staining of deep adipose tissue of patient 2# in the nPGCMN (original magnification × 100). h Hematoxylin-eosin staining of the deep tissue of patient 2# in the dPGCMN (original magnification × 100). The adipose tissue disappears and is replaced by melanocytes. GCMN: Giant congenital melanocytic nevus; nPGCMN: Non-penetrating giant congenital melanocytic nevus; dPGCMN: Deep penetrating giant congenital melanocytic nevus