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Table 5 Identified hub genes

From: Arecoline promotes proliferation and migration of human HepG2 cells through activation of the PI3K/AKT/mTOR pathway

Gene

Protein

UniProtKB ID

Biological process

CDK1

Cyclin-dependent kinase 1

p06493 (CDK1_HUMAN)

Apoptosis, Biological rhythms, Cell cycle, Cell division, Host-virus interaction, Mitosis

CCND1

G1/S-specific cyclin-D1

p24385 (CCND1_HUMAN)

Cell cycle, Cell division, DNA damage, Transcription, Transcription regulation

RAF1

RAF proto-oncogene serine/threonine-protein kinase

p04049 (RAF1_HUMAN)

Activation of adenylate cyclase and MAPK activity, Apoptosis, cell differentiation, death-inducing signaling complex assembly

CDKN1B

Cyclin-dependent kinase inhibitor 1B

p46527 (CDN1B_HUMAN)

Cell cycle

BTRC

F-box/WD repeat-containing protein 1A

Q9Y297 (FBW1A_HUMAN)

Biological rhythms, Host-virus interaction, Ubl conjugation pathway, Wnt pathway