Fig. 2

Consistent DEGs screening, GO enrichment and pathway enrichment analysis. (A and B) Identification of consistently changed DEGs from the four datasets (GSE28750, GSE57065, GSE65682 and GSE69528). The 444 common DEGs can be classified into 246 up-regulated and 198 down-regulated genes . Each color area repersented the corresponding dataset. (C, D and E) The results of GO analysis for the common DEGs were shown in three groups: cellular component (C), molecular function (D), and biological process (E). F The top 10 significant GO terms were shown in a GOCircle plot. The height of bars in the inner ring indicated the -log10 (P values) of GO terms, with higher bars representing higher significance. The colors of these bars indicated the z-score (standard score), with darker colors representing larger absolute value. The scatter plots in the out ring showed the regulation of each gene in the corresponding GO terms, with red representing up-regulated and blue representing down-regulated. The descriptions of GO categories were displayed in the table by the side. G The common DEGs and their linked GO terms were showed by GO chord plot. Different colors corresponding to the genes indicated different fold change levels. H Signaling pathway enrichment analysis for the common DEGs. DEGs, Differentially Expressed Genes. GO, Gene Ontology