HLA-A*03, the hemochromatosis ancestral haplotype, and phenotypes of referred hemochromatosis probands with HFE p.C282Y homozygosity

Table 3 QFe/age in hemochromatosis probands with HFE p.C282Y homozygosity ^a

		Highest quartile, QFe/age, mg/y (n = 26)	Lowest three quartiles, QFe/age, mg/y (n = 78)	Value of p
Men (n = 104)	Median QFe/age, mg/y (range)	1913 (1226, 7143)^b	486 (0, 1217)^b	< 0.0001
	HLA-A^a03 positivity ^c, % (n)	76.9 (20)	85.9 (67)	0.3583
	HLA-A^a03 allele frequency ^d (n)	0.4615 (24/52)	0.5385 (84/156)	0.8535
		Highest quartile, QFe/age, mg/y (n = 19)	Lowest three quartiles, QFe/age, mg/y (n = 57)	Value of p
Women (n = 76)	Median QFe/age, mg/y (range)	1667 (1212, 6452)	444 (0, 1133)	< 0.0001
	HLA-A^a03 positivity ^c, % (n)	68.4 (13)	71.9 (41)	0.7765
	HLA-A^a03 allele frequency ^d (n)	0.4737 (18/38)	0.4561 (52/114)	0.3424

^a Abbreviations: HLA human leukocyte antigen, QFe/age is defined as the quotient of quantity of iron removed to achieve iron depletion by age at diagnosis (mg/y)
^b These values did not differ significantly from corresponding values in women
^c Positivity is defined as either A*03 homozygosity or heterozygosity
^d Allele frequency is defined as the quotient of total A*03 alleles by total A alleles

ISSN: 1601-5223