Fig. 1

Identification of altered genes and associated KEGG analyses from eight groups. A Heatmap showing the top 50 up-regulated and top 50 down-regulated genes from the eight groups. Red = up-regulated; Blue = down-regulated. The expression intensity value is derived from gene expression levels using R software analysis. B Venn diagram showing shared genes between down-regulated genes, recognized oncogenes, lincRNAs, and TSGs. C Venn diagram showing shared genes between up-regulated genes, recognized oncogenes, lincRNAs, and TSGs. D KEGG pathway results of the up-regulated genes. The size of each circle represents the gene number in the corresponding pathway, which is proportional to the circles in the caption. E KEGG pathway results for down-regulated genes; the x-axis represents fold enrichment, different colors represent −log10 (P-value), and circle sizes represent gene numbers in a specific pathway. Abbreviations: lincRNA, long intergenic non-coding RNA; TSG, tumor suppressor gene; KEGG, Kyoto Encyclopedia of Genes and Genomes