Description | Gene markers | HNSC | KIRC | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Tumor | Normal | Tumor | Normal | |||||||
R | P | R | P | R | P | R | P | |||
CD8 + T cell | CD8A | -0.012 | 0.79 | 0.059 | 0.7 | 0.26 | *** | 0.027 | 0.82 | |
CD8B | 0.028 | 0.52 | 0.06 | 0.7 | 0.27 | *** | -0.17 | 0.31 | ||
T cell(general) | CD3D | 0.017 | 0.7 | 0.099 | 0.52 | 0.33 | *** | -0.003 | 0.8 | |
CD3E | 0.029 | 0.51 | 0.13 | 0.41 | 0.32 | *** | -0.15 | 0.22 | ||
CD2 | 0.038 | 0.13 | 0.4 | 0.33 | 0.3 | *** | -0.12 | 0.33 | ||
B cell | CD19 | 0.13 | 0.2 | 0.19 | 0.75 | 0.35 | *** | -0.15 | 0.2 | |
CD79A | 0.093 | * | 0.34 | * | 0.3 | *** | -0.3 | * | ||
Monocyte | CD86 | -0.017 | 0.7 | 0.23 | 0.14 | 0.24 | *** | -0.06 | 0.62 | |
CD115(CSF1R) | 0.019 | 0.67 | 0.22 | 0.16 | 0.33 | *** | -0.072 | 0.55 | ||
TAM | CD68 | -0.087 | * | 0.3 | 0.051 | 0.16 | *** | -0.06 | 0.62 | |
M1Macrophage | INOS(NOS2) | 0.25 | *** | 0.19 | 0.22 | -0.075 | 0.089 | -0.001 | 0.68 | |
IRF5 | 0.16 | *** | 0.57 | *** | 0.35 | *** | -0.049 | 0.68 | ||
M2 Macrophage | VSIG4 | -0.027 | 0.54 | 0.35 | * | 0.27 | *** | 0.0054 | 0.96 | |
Neutrophils | CD11b(ITGAM) | 0.15 | *** | 0.22 | 0.15 | 0.35 | *** | -0.16 | 0.17 | |
CCR7 | 0.054 | 0.22 | 0.14 | 0.36 | 0.28 | *** | -0.034 | 0.77 | ||
Dendritic cell | CD11c(ITGAX) | 0.12 | ** | 0.37 | * | 0.43 | *** | -0.12 | 0.33 | |
Th1 | STAT4 | 0.072 | 0.1 | 0.26 | 0.091 | 0.38 | *** | - 0.063 | 0.6 | |
IFN-γ(IFNG) | -0.025 | 0.56 | -0.049 | 0.75 | 0.31 | *** | 0.12 | 0.34 | ||
TNF-α(TNF) | 0.084 | 0.055 | 0.068 | 0.66 | 0.28 | *** | 0.27 | * | ||
Th2 | STAT5A | 0.19 | *** | 0.27 | 0.079 | 0.36 | *** | 0.17 | 0.16 | |
Tfh | BCL6 | 0.26 | *** | 0.4 | ** | 0.33 | *** | 0.78 | *** | |
Treg | FOXP3 | 0.087 | * | 0.34 | * | 0.33 | *** | 0.48 | *** | |
CCR8 | 0.06 | 0.17 | 0.13 | 0.39 | 0.33 | *** | -0.16 | 0.17 | ||
TGFβ(TGFB1) | 0.039 | 0.38 | 0.39 | ** | 0.34 | *** | 0.76 | *** | ||
Tcell exhaustion | PD-1(PDCD1) | 0.051 | 0.25 | 0.099 | 0.52 | 0.4 | *** | -0.18 | 0.14 | |
CTLA4 | 0.086 | 0.051 | 0.16 | 0.31 | 0.42 | *** | -0.044 | 0.72 | ||
LAG3 | 0.039 | 0.37 | 0.15 | 0.32 | 0.39 | *** | 0.73 | *** |