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Table 2 Correlation analysis between LPAR2 and relate genes and markers of immune cells in TIMER

From: LPAR2 correlated with different prognosis and immune cell infiltration in head and neck squamous cell carcinoma and kidney renal clear cell carcinoma

Description

Gene markers

HNSC

   

KIRC

 
  

None

 

Purity

 

None

 

Purity

 
  

Cor

P

Cor

P

Cor

P

Cor

P

CD8 + T cell

CD8A

0.035

4.21e-01

0.101

2.52e-02

0.243

***

0.201

***

CD8B

0.086

4.88e-02

0.144

*

0.26

***

0.226

***

T cell(general)

CD3D

0.102

2.04e-02

0.179

***

0.308

***

0.271

***

CD3E

0.082

6.03e-02

0.159

**

0.303

***

0.263

***

CD2

0.099

2.39e-02

0.166

**

0.289

***

0.244

***

B cell

CD19

0.185

***

0.256

***

0.354

***

0.309

***

CD79A

0.157

**

0.216

***

0.308

***

0.265

***

Monocyte

CD86

0.009

8.45e-01

0.067

1.39e-01

0.232

***

0.215

***

CD115(CSF1R)

0.024

5.91e-01

0.086

5.52e-02

0.289

***

0.266

***

TAM

CCL2

-0.019

6.65e-01

0.036

4.27e-01

-0.072

9.48e-02

-0.122

*

CD68

-0.1

2.23e-02

-0.066

1.43e-01

0.227

***

0.241

***

IL10

-0.063

1.50e-01

-0.002

9.66e-01

0.118

*

0.072

1.20e-01

M1Macrophage

INOS(NOS2)

0.262

***

0.252

***

-0.127

*

-0.127

*

IRF5

0.173

***

0.18

***

0.301

***

0.301

***

COX2(PTGS2)

-0.017

6.95e-01

-0.043

3.38e-01

0.057

1.92e-01

0.057

1.92e-01

M2 Macrophage

CD163

-0.017

6.92e-01

0.04

3.76e-01

0.123

*

0.113

1.53e-02

VSIG4

-0.027

5.33e-01

0.034

4.52e-01

0.247

***

0.233

***

MS4A4A

0.006

8.91e-01

0.069

1.28e-01

0.12

*

0.081

8.11e-02

Neutrophils

CD66b(CEACAM8)

0.053

2.29e-01

0.045

3.22e-01

-0.007

8.72e-01

-0.012

7.90e-01

CD11b(ITGAM)

0.131

*

0.161

**

0.271

***

0.261

***

CCR7

0.083

5.91e-02

0.154

**

0.275

***

0.25

***

Naturalkiller cell

KIR2DL1

0.026

5.51e-01

0.06

1.83e-01

-0.06

1.67e-01

-0.061

1.94e-01

KIR2DL3

0.003

8.49e-01

0.043

3.46e-01

0.005

9.00e-01

0.024

6.13e-01

KIR2DL4

0.009

8.44e-01

0.063

1.62e-01

0.136

*

0.122

*

KIR3DL1

0.012

7.83e-01

0.042

3.57e-01

-0.066

1.29e-01

-0.051

2.73e-01

KIR3DL2

0.036

4.01e-01

0.069

1.26e-01

0.059

1.71e-01

0.071

1.29e-01

KIR3DL3

0.059

1.76e-01

0.094

3.78e-02

0.028

5.16e-01

0.012

8.01e-01

KIR2DS4

0.052

2.38e-01

0.087

5.45e-02

0.004

9.36e-01

0.01

8.35e-01

Dendritic cell

HLA-DPB1

0.065

1.40e-01

0.135

2.64e-03

0.191

***

0.178

***

HLA-DQB1

0.064

1.44e-01

0.108

1.63e-02

0.093

3.21e-02

0.073

1.19e-01

HLA-DRA

0.014

7.52e-01

0.078

8.27e-02

0.128

*

0.111

1.67e-02

HLA-DPA1

0.023

5.97e-01

0.085

5.92e-02

0.136

*

0.105

2.43e-02

BCDA-1(CD1C)

0.019

6.66e-01

0.084

6.20e-02

0.04

3.58e-01

0.002

9.66e-01

BDCA-4(NRP1)

-0.067

1.25e-01

-0.026

5.62e-01

-0.123

*

-0.169

**

CD11c(ITGAX)

0.095

3.02e-02

0.173

*

0.315

***

0.313

***

Th1

T-bet (TBX21)

0.081

6.35e-02

0.142

*

0.145

**

0.112

1.62e-02

STAT4

0.088

4.48e-02

0.145

*

0.297

***

0.259

***

STAT1

-0.052

2.37e-01

-0.012

7.87e-01

0.195

***

0.154

**

IFN-γ(IFNG)

0.017

7.05e-01

0.076

9.04e-02

0.284

***

0.243

***

TNF-α(TNF)

0.052

2.32e-01

0.067

1.40e-01

0.24

***

0.212

***

Th2

GATA3

0.04

3.65e-01

0.078

8.50e-02

0.174

***

0.147

*

STAT6

0.172

***

0.168

**

0.141

*

0.151

*

STAT5A

0.23

***

0.255

9.09e-02

0.312

***

0.271

***

IL13

0.075

8.69e-02

0.115

1.06e-02

0.153

**

0.126

*

Tfh

BCL6

0.264

***

0.236

***

0.292

***

0.279

***

IL21

0.001

9.76e-01

0.03

5.06e-01

0.161

**

0.155

**

Th17

STAT3

0.056

2.01e-01

0.054

2.32e-01

0.029

4.99e-01

-0.003

9.41e-01

IL17A

-0.013

7.69e-01

0.014

7.53e-01

0.058

1.79e-01

0.031

5.11e-01

Treg

FOXP3

0.08

6.9e-02

0.133

*

0.444

***

0.418

***

CCR8

0.022

6.09e-01

0.062

1.71e-01

0.285

***

0.246

***

STAT5B

0.084

5.61e-02

0.092

4.08e-02

-0.144

***

-0.156

**

TGFβ(TGFB1)

-0.054

2.18e-01

-0.031

4.95e-01

0.29

***

0.265

***

T cell exhaustion

PD-1(PDCD1)

0.11

1.19e-02

0.174

**

0.378

***

0.357

***

CTLA4

0.125

*

0.199

***

0.364

***

0.333

***

LAG3

0.099

2.40e-02

0.152

**

0.359

***

0.321

***

TIM-3(HAVCR2)

0.063

1.49e-01

0.123

*

-0.009

8.44e-01

-0.022

6.34e-01

GZMB

0.039

3.76e-01

0.096

3.27e-02

0.103

1.71e-02

0.085

6.77e-02

  1. Cor, R value of Spearman’s correlation; None, correlation without adjustment. Purity, correlation adjusted by purity. *P < 0 .01(1e-02); **P < 0.001(1e-03); ***P < 0.0001(1e-04)
  2. Abbreviations: HNSC Head and Neck squamous cell carcinoma, KIRC kidney renal clear cell carcinoma, TAM tumor-correlated macrophage, Tfh follicular helper T cell, Th T helper cell, Treg regulatory T cell