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Table 2 Correlation analysis between LPAR2 and relate genes and markers of immune cells in TIMER

From: LPAR2 correlated with different prognosis and immune cell infiltration in head and neck squamous cell carcinoma and kidney renal clear cell carcinoma

Description Gene markers HNSC     KIRC  
   None   Purity   None   Purity  
   Cor P Cor P Cor P Cor P
CD8 + T cell CD8A 0.035 4.21e-01 0.101 2.52e-02 0.243 *** 0.201 ***
CD8B 0.086 4.88e-02 0.144 * 0.26 *** 0.226 ***
T cell(general) CD3D 0.102 2.04e-02 0.179 *** 0.308 *** 0.271 ***
CD3E 0.082 6.03e-02 0.159 ** 0.303 *** 0.263 ***
CD2 0.099 2.39e-02 0.166 ** 0.289 *** 0.244 ***
B cell CD19 0.185 *** 0.256 *** 0.354 *** 0.309 ***
CD79A 0.157 ** 0.216 *** 0.308 *** 0.265 ***
Monocyte CD86 0.009 8.45e-01 0.067 1.39e-01 0.232 *** 0.215 ***
CD115(CSF1R) 0.024 5.91e-01 0.086 5.52e-02 0.289 *** 0.266 ***
TAM CCL2 -0.019 6.65e-01 0.036 4.27e-01 -0.072 9.48e-02 -0.122 *
CD68 -0.1 2.23e-02 -0.066 1.43e-01 0.227 *** 0.241 ***
IL10 -0.063 1.50e-01 -0.002 9.66e-01 0.118 * 0.072 1.20e-01
M1Macrophage INOS(NOS2) 0.262 *** 0.252 *** -0.127 * -0.127 *
IRF5 0.173 *** 0.18 *** 0.301 *** 0.301 ***
COX2(PTGS2) -0.017 6.95e-01 -0.043 3.38e-01 0.057 1.92e-01 0.057 1.92e-01
M2 Macrophage CD163 -0.017 6.92e-01 0.04 3.76e-01 0.123 * 0.113 1.53e-02
VSIG4 -0.027 5.33e-01 0.034 4.52e-01 0.247 *** 0.233 ***
MS4A4A 0.006 8.91e-01 0.069 1.28e-01 0.12 * 0.081 8.11e-02
Neutrophils CD66b(CEACAM8) 0.053 2.29e-01 0.045 3.22e-01 -0.007 8.72e-01 -0.012 7.90e-01
CD11b(ITGAM) 0.131 * 0.161 ** 0.271 *** 0.261 ***
CCR7 0.083 5.91e-02 0.154 ** 0.275 *** 0.25 ***
Naturalkiller cell KIR2DL1 0.026 5.51e-01 0.06 1.83e-01 -0.06 1.67e-01 -0.061 1.94e-01
KIR2DL3 0.003 8.49e-01 0.043 3.46e-01 0.005 9.00e-01 0.024 6.13e-01
KIR2DL4 0.009 8.44e-01 0.063 1.62e-01 0.136 * 0.122 *
KIR3DL1 0.012 7.83e-01 0.042 3.57e-01 -0.066 1.29e-01 -0.051 2.73e-01
KIR3DL2 0.036 4.01e-01 0.069 1.26e-01 0.059 1.71e-01 0.071 1.29e-01
KIR3DL3 0.059 1.76e-01 0.094 3.78e-02 0.028 5.16e-01 0.012 8.01e-01
KIR2DS4 0.052 2.38e-01 0.087 5.45e-02 0.004 9.36e-01 0.01 8.35e-01
Dendritic cell HLA-DPB1 0.065 1.40e-01 0.135 2.64e-03 0.191 *** 0.178 ***
HLA-DQB1 0.064 1.44e-01 0.108 1.63e-02 0.093 3.21e-02 0.073 1.19e-01
HLA-DRA 0.014 7.52e-01 0.078 8.27e-02 0.128 * 0.111 1.67e-02
HLA-DPA1 0.023 5.97e-01 0.085 5.92e-02 0.136 * 0.105 2.43e-02
BCDA-1(CD1C) 0.019 6.66e-01 0.084 6.20e-02 0.04 3.58e-01 0.002 9.66e-01
BDCA-4(NRP1) -0.067 1.25e-01 -0.026 5.62e-01 -0.123 * -0.169 **
CD11c(ITGAX) 0.095 3.02e-02 0.173 * 0.315 *** 0.313 ***
Th1 T-bet (TBX21) 0.081 6.35e-02 0.142 * 0.145 ** 0.112 1.62e-02
STAT4 0.088 4.48e-02 0.145 * 0.297 *** 0.259 ***
STAT1 -0.052 2.37e-01 -0.012 7.87e-01 0.195 *** 0.154 **
IFN-γ(IFNG) 0.017 7.05e-01 0.076 9.04e-02 0.284 *** 0.243 ***
TNF-α(TNF) 0.052 2.32e-01 0.067 1.40e-01 0.24 *** 0.212 ***
Th2 GATA3 0.04 3.65e-01 0.078 8.50e-02 0.174 *** 0.147 *
STAT6 0.172 *** 0.168 ** 0.141 * 0.151 *
STAT5A 0.23 *** 0.255 9.09e-02 0.312 *** 0.271 ***
IL13 0.075 8.69e-02 0.115 1.06e-02 0.153 ** 0.126 *
Tfh BCL6 0.264 *** 0.236 *** 0.292 *** 0.279 ***
IL21 0.001 9.76e-01 0.03 5.06e-01 0.161 ** 0.155 **
Th17 STAT3 0.056 2.01e-01 0.054 2.32e-01 0.029 4.99e-01 -0.003 9.41e-01
IL17A -0.013 7.69e-01 0.014 7.53e-01 0.058 1.79e-01 0.031 5.11e-01
Treg FOXP3 0.08 6.9e-02 0.133 * 0.444 *** 0.418 ***
CCR8 0.022 6.09e-01 0.062 1.71e-01 0.285 *** 0.246 ***
STAT5B 0.084 5.61e-02 0.092 4.08e-02 -0.144 *** -0.156 **
TGFβ(TGFB1) -0.054 2.18e-01 -0.031 4.95e-01 0.29 *** 0.265 ***
T cell exhaustion PD-1(PDCD1) 0.11 1.19e-02 0.174 ** 0.378 *** 0.357 ***
CTLA4 0.125 * 0.199 *** 0.364 *** 0.333 ***
LAG3 0.099 2.40e-02 0.152 ** 0.359 *** 0.321 ***
TIM-3(HAVCR2) 0.063 1.49e-01 0.123 * -0.009 8.44e-01 -0.022 6.34e-01
GZMB 0.039 3.76e-01 0.096 3.27e-02 0.103 1.71e-02 0.085 6.77e-02
  1. Cor, R value of Spearman’s correlation; None, correlation without adjustment. Purity, correlation adjusted by purity. *P < 0 .01(1e-02); **P < 0.001(1e-03); ***P < 0.0001(1e-04)
  2. Abbreviations: HNSC Head and Neck squamous cell carcinoma, KIRC kidney renal clear cell carcinoma, TAM tumor-correlated macrophage, Tfh follicular helper T cell, Th T helper cell, Treg regulatory T cell