Description | Gene markers | HNSC | Â | Â | Â | KIRC | Â | ||
---|---|---|---|---|---|---|---|---|---|
 |  | None |  | Purity |  | None |  | Purity |  |
 |  | Cor | P | Cor | P | Cor | P | Cor | P |
CD8 + T cell | CD8A | 0.035 | 4.21e-01 | 0.101 | 2.52e-02 | 0.243 | *** | 0.201 | *** |
CD8B | 0.086 | 4.88e-02 | 0.144 | * | 0.26 | *** | 0.226 | *** | |
T cell(general) | CD3D | 0.102 | 2.04e-02 | 0.179 | *** | 0.308 | *** | 0.271 | *** |
CD3E | 0.082 | 6.03e-02 | 0.159 | ** | 0.303 | *** | 0.263 | *** | |
CD2 | 0.099 | 2.39e-02 | 0.166 | ** | 0.289 | *** | 0.244 | *** | |
B cell | CD19 | 0.185 | *** | 0.256 | *** | 0.354 | *** | 0.309 | *** |
CD79A | 0.157 | ** | 0.216 | *** | 0.308 | *** | 0.265 | *** | |
Monocyte | CD86 | 0.009 | 8.45e-01 | 0.067 | 1.39e-01 | 0.232 | *** | 0.215 | *** |
CD115(CSF1R) | 0.024 | 5.91e-01 | 0.086 | 5.52e-02 | 0.289 | *** | 0.266 | *** | |
TAM | CCL2 | -0.019 | 6.65e-01 | 0.036 | 4.27e-01 | -0.072 | 9.48e-02 | -0.122 | * |
CD68 | -0.1 | 2.23e-02 | -0.066 | 1.43e-01 | 0.227 | *** | 0.241 | *** | |
IL10 | -0.063 | 1.50e-01 | -0.002 | 9.66e-01 | 0.118 | * | 0.072 | 1.20e-01 | |
M1Macrophage | INOS(NOS2) | 0.262 | *** | 0.252 | *** | -0.127 | * | -0.127 | * |
IRF5 | 0.173 | *** | 0.18 | *** | 0.301 | *** | 0.301 | *** | |
COX2(PTGS2) | -0.017 | 6.95e-01 | -0.043 | 3.38e-01 | 0.057 | 1.92e-01 | 0.057 | 1.92e-01 | |
M2 Macrophage | CD163 | -0.017 | 6.92e-01 | 0.04 | 3.76e-01 | 0.123 | * | 0.113 | 1.53e-02 |
VSIG4 | -0.027 | 5.33e-01 | 0.034 | 4.52e-01 | 0.247 | *** | 0.233 | *** | |
MS4A4A | 0.006 | 8.91e-01 | 0.069 | 1.28e-01 | 0.12 | * | 0.081 | 8.11e-02 | |
Neutrophils | CD66b(CEACAM8) | 0.053 | 2.29e-01 | 0.045 | 3.22e-01 | -0.007 | 8.72e-01 | -0.012 | 7.90e-01 |
CD11b(ITGAM) | 0.131 | * | 0.161 | ** | 0.271 | *** | 0.261 | *** | |
CCR7 | 0.083 | 5.91e-02 | 0.154 | ** | 0.275 | *** | 0.25 | *** | |
Naturalkiller cell | KIR2DL1 | 0.026 | 5.51e-01 | 0.06 | 1.83e-01 | -0.06 | 1.67e-01 | -0.061 | 1.94e-01 |
KIR2DL3 | 0.003 | 8.49e-01 | 0.043 | 3.46e-01 | 0.005 | 9.00e-01 | 0.024 | 6.13e-01 | |
KIR2DL4 | 0.009 | 8.44e-01 | 0.063 | 1.62e-01 | 0.136 | * | 0.122 | * | |
KIR3DL1 | 0.012 | 7.83e-01 | 0.042 | 3.57e-01 | -0.066 | 1.29e-01 | -0.051 | 2.73e-01 | |
KIR3DL2 | 0.036 | 4.01e-01 | 0.069 | 1.26e-01 | 0.059 | 1.71e-01 | 0.071 | 1.29e-01 | |
KIR3DL3 | 0.059 | 1.76e-01 | 0.094 | 3.78e-02 | 0.028 | 5.16e-01 | 0.012 | 8.01e-01 | |
KIR2DS4 | 0.052 | 2.38e-01 | 0.087 | 5.45e-02 | 0.004 | 9.36e-01 | 0.01 | 8.35e-01 | |
Dendritic cell | HLA-DPB1 | 0.065 | 1.40e-01 | 0.135 | 2.64e-03 | 0.191 | *** | 0.178 | *** |
HLA-DQB1 | 0.064 | 1.44e-01 | 0.108 | 1.63e-02 | 0.093 | 3.21e-02 | 0.073 | 1.19e-01 | |
HLA-DRA | 0.014 | 7.52e-01 | 0.078 | 8.27e-02 | 0.128 | * | 0.111 | 1.67e-02 | |
HLA-DPA1 | 0.023 | 5.97e-01 | 0.085 | 5.92e-02 | 0.136 | * | 0.105 | 2.43e-02 | |
BCDA-1(CD1C) | 0.019 | 6.66e-01 | 0.084 | 6.20e-02 | 0.04 | 3.58e-01 | 0.002 | 9.66e-01 | |
BDCA-4(NRP1) | -0.067 | 1.25e-01 | -0.026 | 5.62e-01 | -0.123 | * | -0.169 | ** | |
CD11c(ITGAX) | 0.095 | 3.02e-02 | 0.173 | * | 0.315 | *** | 0.313 | *** | |
Th1 | T-bet (TBX21) | 0.081 | 6.35e-02 | 0.142 | * | 0.145 | ** | 0.112 | 1.62e-02 |
STAT4 | 0.088 | 4.48e-02 | 0.145 | * | 0.297 | *** | 0.259 | *** | |
STAT1 | -0.052 | 2.37e-01 | -0.012 | 7.87e-01 | 0.195 | *** | 0.154 | ** | |
IFN-γ(IFNG) | 0.017 | 7.05e-01 | 0.076 | 9.04e-02 | 0.284 | *** | 0.243 | *** | |
TNF-α(TNF) | 0.052 | 2.32e-01 | 0.067 | 1.40e-01 | 0.24 | *** | 0.212 | *** | |
Th2 | GATA3 | 0.04 | 3.65e-01 | 0.078 | 8.50e-02 | 0.174 | *** | 0.147 | * |
STAT6 | 0.172 | *** | 0.168 | ** | 0.141 | * | 0.151 | * | |
STAT5A | 0.23 | *** | 0.255 | 9.09e-02 | 0.312 | *** | 0.271 | *** | |
IL13 | 0.075 | 8.69e-02 | 0.115 | 1.06e-02 | 0.153 | ** | 0.126 | * | |
Tfh | BCL6 | 0.264 | *** | 0.236 | *** | 0.292 | *** | 0.279 | *** |
IL21 | 0.001 | 9.76e-01 | 0.03 | 5.06e-01 | 0.161 | ** | 0.155 | ** | |
Th17 | STAT3 | 0.056 | 2.01e-01 | 0.054 | 2.32e-01 | 0.029 | 4.99e-01 | -0.003 | 9.41e-01 |
IL17A | -0.013 | 7.69e-01 | 0.014 | 7.53e-01 | 0.058 | 1.79e-01 | 0.031 | 5.11e-01 | |
Treg | FOXP3 | 0.08 | 6.9e-02 | 0.133 | * | 0.444 | *** | 0.418 | *** |
CCR8 | 0.022 | 6.09e-01 | 0.062 | 1.71e-01 | 0.285 | *** | 0.246 | *** | |
STAT5B | 0.084 | 5.61e-02 | 0.092 | 4.08e-02 | -0.144 | *** | -0.156 | ** | |
TGFβ(TGFB1) | -0.054 | 2.18e-01 | -0.031 | 4.95e-01 | 0.29 | *** | 0.265 | *** | |
T cell exhaustion | PD-1(PDCD1) | 0.11 | 1.19e-02 | 0.174 | ** | 0.378 | *** | 0.357 | *** |
CTLA4 | 0.125 | * | 0.199 | *** | 0.364 | *** | 0.333 | *** | |
LAG3 | 0.099 | 2.40e-02 | 0.152 | ** | 0.359 | *** | 0.321 | *** | |
TIM-3(HAVCR2) | 0.063 | 1.49e-01 | 0.123 | * | -0.009 | 8.44e-01 | -0.022 | 6.34e-01 | |
GZMB | 0.039 | 3.76e-01 | 0.096 | 3.27e-02 | 0.103 | 1.71e-02 | 0.085 | 6.77e-02 |