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Fig. 5 | Hereditas

Fig. 5

From: SLC3A2 inhibits ferroptosis in laryngeal carcinoma via mTOR pathway

Fig. 5

SLC3A2 inhibits ferroptosis partly through mTOR pathway. A SLC3A2-Knockdown laryngeal cancer cells were treated with or without L-Leu (activator of mTOR pathway), the protein expression of mTOR, p-mTOR, P70S6K and p-P70S6K was measured by western blotting. B-F The same cells were treated as in (A), then western blotting was perform to measure the ferroptosis related protein expression. G HN13 cells stably expressing control, SLC3A2 knockdown plasmids were injected subcutaneously into nude mice. Representative images showing xenograft mice tumors at day 28 post subcutaneous injection (n = 3). Tumor sizes were measured and depicted as tumor volume and tumor weight. Results presented represent the means of triplicate experiments ± SEM. **p < 0.01. (H) IHC analysis of SLC3A2 and GPX4 expression in xenograft mice tumors. Scale bars, 100 μm

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