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Fig. 3 | Hereditas

Fig. 3

From: TGF-β1/SMOC2/AKT and ERK axis regulates proliferation, migration, and fibroblast to myofibroblast transformation in lung fibroblast, contributing with the asthma progression

Fig. 3

SMOC2 regulated FMT of lung fibroblasts. HBFs and IMR-90 cells were transfected with shNC, shSMOC2, vector or SMOC2, and then treated with TGF-β1. (A) Flow cytometry analysis was performed to demonstrate the number of myofibroblasts in HBFs and IMR-90 cells. **p < 0.01 compared with NT group; &&p < 0.01 compared with shNC+TGF-β1 group; @p < 0.05 compared with vector+TGF-β1 group. (B) The protein levels of collagen I and α-SMA in HBFs and IMR-90 cells were evaluated via western blot analysis. **p < 0.01 compared with NT group; &&p < 0.01 compared with shNC+TGF-β1 group; @@p < 0.01 compared with vector+TGF-β1 group. (C) IF staining was perfoemed to measure the protein content and distribution of α-SMA in HBFs and IMR-90 cells

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Hereditas

ISSN: 1601-5223

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