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Fig. 2 | Hereditas

Fig. 2

From: TGF-β1/SMOC2/AKT and ERK axis regulates proliferation, migration, and fibroblast to myofibroblast transformation in lung fibroblast, contributing with the asthma progression

Fig. 2

SMOC2 modulated the proliferation and migration of lung fibroblasts. (A) RT-qPCR was carried out to disclose the expression of SMOC2 in HBFs and IMR-90 cells after transfection of shNC, shSMOC2, vector or SMOC2. **p < 0.01 compared with NT group; &&p < 0.01 compared with vector group. (B) The protein level of SMOC2 was assessed via western blot analysis in HBFs and IMR-90 cells after transfection of shNC, shSMOC2, vector or SMOC2. **p < 0.01 compared with NT group; &&p < 0.01 compared with vector group. (C) BrdU assay was performe to assess the proliferation of HBFs and IMR-90 cells after TGF-β1 treatment or combined with transfection of shNC, shSMOC2, vector or SMOC2. **p < 0.01 compared with NT group; &&p < 0.01 compared with shNC+TGF-β1 group; @@p < 0.01 compared with vector+TGF-β1 group. (D) The migration ability was detected by wound-healing assay in HBFs and IMR-90 cells after TGF-β1 treatment or combined with transfection of shNC, shSMOC2, vector or SMOC2. **p < 0.01 compared with NT group; &&p < 0.01 compared with shNC+TGF-β1 group; @@p < 0.01 compared with vector+TGF-β1 group

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Hereditas

ISSN: 1601-5223

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