Fig. 1

Relationship between differences in compartments and gene expression between primary monocytes and THP-1 cells. a Comparison of gene expression levels at regions that switched from A- compartment in the primary monocytes to B-compartment in the monocytic THP-1 cells (“***” represents p < 0.001, Wilcoxon rank sum test) TPM refers to transcript per million. b Gene ontology analysis of the genes that reside in the compartments described in (a). Colored in green are those terms related to typical immune cell functions. c Example of immune cell-related genes (DEFA1, DEFA1B, DEFA3) whose changed expression is associated with the different compartments depicted in (a). A-compartments are colored in red and B-compartments are colored in blue. d Comparison of gene expression levels at regions that switched from B-compartment in primary monocytes to A-compartment in the monocytic THP-1 cells (“***” represents p < 0.001, Wilcoxon rank sum test). e Gene ontology analysis of the genes reside in the compartments described in (d). Colored in purple are those terms related to cell proliferation. f Example of a gene that plays a role in the regulation of cell division (CDC7) whose changed expression is associated with the different compartments. A-compartments are colored in red and B-compartments are colored in blue