Table 2 Top 10 up- and downregulated DEGs
From: Identification of crucial genes involved in pathogenesis of regional weakening of the aortic wall
Gene symbol | Log FC | P-Value | Gene official full name |
|---|---|---|---|
UP-regulated | |||
IGLL5 | 4.085 | 0.000788 | Immunoglobulin lambda like polypeptide 5 |
SFRP4 | 4.048333 | 0.00244 | Secreted frizzled related protein 4 |
SAA2 | 3.856667 | 3.63E-06 | Serum amyloid A2 |
HLA-DRB5 | 3.7725 | 0.000798 | Major histocompatibility complex, class II, DR beta 5 |
CD79A | 3.7375 | 0.00175 | CD79a molecule |
IBSP | 3.65 | 0.019102 | Integrin binding sialoprotein |
MMP12 | 3.648333 | 0.012571 | Matrix metallopeptidase 12 |
CXCL13 | 3.636667 | 0.014243 | C-X-C motif chemokine ligand 13 |
DCC | 3.555833 | 0.001552 | DCC netrin 1 receptor |
FDCSP | 3.548333 | 0.018089 | Follicular dendritic cell secreted protein |
DOWN-regulated | |||
CNN1 | -7.26083 | 5.03E-09 | Calponin 1 |
ITGA8 | -6.8025 | 3.15E-07 | Integrin subunit alpha 8 |
ACTC1 | -6.3375 | 8.10E-06 | Actin, alpha, cardiac muscle 1 |
MYH11 | -6.31667 | 3.48E-06 | Myosin heavy chain 11 |
MFAP4 | -5.71417 | 1.54E-05 | Microfibrillar associated protein 4 |
PLN | -5.65833 | 3.44E-07 | Phospholamban |
MYOCD | -5.61333 | 2.76E-07 | Myocardin |
PPP1R12B | -5.51 | 3.17E-07 | Protein phosphatase 1 regulatory subunit 12B |
RCAN2 | -5.41333 | 1.96E-09 | Regulator of calcineurin 2 |
PCDH7 | -5.405 | 4.90E-07 | Protocadherin 7 |