Fig. 1
From: Leopard syndrome: the potential cardiac defect underlying skin phenotypes
a Clinical manifestation of the patient. Multiple pigmented spots were unevenly distributed in different areas of his body, predominantly concentrated on the face, and involved the palpebral conjunctiva. b The spots were scattered with various light-to-dark brown colors and heterogeneous sizes less than 3 mm. c Histological analysis confirmed the diagnosis of multiple lentigines (hematoxylin–eosin, original magnification × 100). d Sanger sequence of germline mutation of PTPN11 (Tyr279Cys, c.836A > G). e ECG examination showed extreme right axis deviation (QRS axis: + 232°; Paper speed: 25mm/s; Sensitivity: 10mm/mV)