Fig. 3
From: Somatic frameshift mutation in PIK3CA causes CLOVES syndrome by provoking PI3K/AKT/mTOR pathway
qRT-PCR results and representative western blots of PI3K/AKT/mTOR pathway. a The expression of PIK3CA mRNA in the patient’s lesion of dermis was comparable to that of an age and sex-matched control. b The GAPDH was used as a control. The phosphorylation of AKT at Ser473 and Thr308 is significantly elevated in the four mutations compared with the empty vector and wild-type (WT)