Fig. 2

Clinical features of the pedigree with sagittal craniosynostosis. a Pedigree of the family. Proband is marked with an upward arrow. Open squares/circles denote unaffected individuals; squares denote males and circles denote females. b Schematic diagram of fetal position before delivery. Proband (II-1) was in breech presentation at left side of the uterus, while her healthy sister (II-2) was in cephalic presentation at right side of the uterus. c Computerized tomographic (CT) scan revealed premature closure of sagittal suture (solid circle) and digital impressions (arrowheads) in proband’s head (left panel). Cranial index of the proband is 70.9%. The co-twin sister was also received CT examination under the request of the parents. Her sagittal suture remains patent (dotted circle) and cranial index is 83.2% (right panel)