Fig. 3

Validation of hub genes in TCGA database and Human Protein Atlas database. a Box plots show the mRNA levels of the 10 hub genes (FN1, CXCL8, CXCL10, SPP1, FOXM1, AURKA, ISG15, PLAUR, TPX2, and BIRC5) in HNSCC/OSCC tissues and normal oral tissues using data from the TCGA database in GEPIA (http://gepia.cancer-pku.cn/index.html). The validation results were consistent with these observed in GEO datasets. *P < 0.05 was considered statistically significant. b Representative immunohistochemistry images of AURKA, BIRC5, FN1, ISG15, SPP1, TPX2 in OSCC and normal oral tissues derived from the Human Protein Atlas database; OSCC, Oral squamous cell carcinoma; HNSCC, Head and neck squamous cell carcinoma; TCGA, The Cancer Genome Atlas