Table 2 Genotype and allele distributions in ACS patients and control subjects
Polymorphisms | Uygur | Han | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Control (n = 461) | ACS (n = 471) | OR | 95%CI | P-value | Control (n = 687) | ACS (n = 547) | OR | 95%CI | P-value | |||
rs6576776 | Genotype | CC | 14 (3.0) | 30 (6.4) | 2.493 | 1.295-4.802 | 0.001 | 40 (5.8) | 26 (4.8) | 0.797 | 0.477-1.333 | 0.68 |
CG | 141 (30.6) | 178 (37.8) | 0.589 | 0.301-1.153 | 230 (33.5) | 181 (33.1) | 1.211 | 0.712-2.058 | ||||
GG | 306 (66.4) | 263 (55.8) | 0.401 | 0.208-0.772 | 417 (60.7) | 340 (62.2) | 1.254 | 0.750-2.097 | ||||
Dominant model | CC+CG | 155(33.6) | 208(44.2) | 1.561 | 1.197-2.036 | 0.001 | 270 (39.3) | 207 (37.8) | 0.94 | 0.746-1.184 | 0.601 | |
GG | 306(66.4) | 263(55.8) | 417 (60.7) | 340 (62.2) | ||||||||
Recessive model | CC | 14(3.0) | 30(6.4) | 0.46 | 0.241-0.880 | 0.016 | 40 (5.8) | 26(4.8) | 1.239 | 0.746-2.057 | 0.407 | |
CG+GG | 447(97.0) | 441(93.6) | 647 (94.2) | 521 (95.2) | ||||||||
Allele | C | 169(18.3) | 238(25.3) | 0.664 | 0.532-0.829 | <0.001 | 310 (22.6) | 233 (21.3) | 1.077 | 0.888-1.305 | 0.451 | |
G | 753(81.7) | 704(74.7) | 1064 (77.4) | 861 (78.7) | ||||||||
rs954353 | Genotype | AA | 205 (44.5) | 208 (44.2) | 1.118 | 0.726-1.723 | 0.777 | 285 (41.5) | 220 (40.2) | 1.049 | 0.727-1.516 | 0.714 |
GA | 202 (43.8) | 214 (45.4) | 1.044 | 0.795-1.371 | 315 (45.9) | 263 (48.1) | 1.082 | 0.851-1.375 | ||||
GG | 54 (11.7) | 49 (10.4) | 0.894 | 0.581-1.378 | 87 (12.7) | 64 (11.7) | 0.953 | 0.660-1.376 | ||||
Dominant model | GA+GG | 256 (55.5) | 263(55.8) | 1.013 | 0.782-1.311 | 0.925 | 402 (58.5) | 327 (59.8) | 1.054 | 0.838-1.324 | 0.653 | |
AA | 205 (44.5) | 208 (44.2) | 285 (41.5) | 220 (40.2) | ||||||||
Recessive model | GG | 54(11.7) | 49 (10.4) | 1.143 | 0.758-1.722 | 0.524 | 87 (12.7) | 64 (11.7) | 1.094 | 0.776-1.544 | 0.608 | |
AA+GA | 407 (88.3) | 422 (89.6) | 600 (87.3) | 483 (88.3) | ||||||||
Allele | A | 612 (66.4) | 630 (66.9) | 0.978 | 0.806-1.185 | 0.818 | 885 (64.4) | 703 (64.3) | 1.007 | 0.853-1.188 | 0.938 | |
G | 310(33.6) | 312 (33.1) | 489 (35.6) | 391 (35.7) | ||||||||
rs3753794 | Genotype | GG | 187 (40.6) | 190 (40.3) | 1.227 | 0.809-1.860 | 0.429 | 298 (43.4) | 238 (43.5) | 0.849 | 0.579-1.243 | 0.556 |
GA | 210 (45.6) | 228 (48.4) | 1.311 | 0.871-1.974 | 321 (46.7) | 245 (44.8) | 0.811 | 0.555-1.185 | ||||
AA | 64 (13.9) | 53 (11.3) | 0.8115 | 0.538-1.236 | 68 (9.9) | 64 (11.7) | 1.178 | 0.805-1.726 | ||||
Dominant model | AA+GA | 274 (59.4) | 281 (59.7) | 1.009 | 0.777-1.311 | 0.944 | 389 (56.6) | 309 (56.5) | 0.995 | 0.793-1.248 | 0.963 | |
GG | 187 (40.6) | 190 (40.3) | 298 (43.4) | 238 (43.5) | ||||||||
Recessive model | AA | 64 (13.9) | 53 (11.3) | 0.787 | 0.533-1.161 | 0.226 | 68 (9.9) | 64 (11.7) | 1.206 | 0.840-1.731 | 0.309 | |
GA+GG | 397 (86.1) | 418 (88.7) | 619 (90.1) | 483 (88.3) | ||||||||
Allele | A | 338 (36.7) | 334 (35.7) | 1.043 | 0.863-1.261 | 0.662 | 457 (33.3) | 373 (34.1) | 0.963 | 0.814-1.140 | 0.663 | |
G | 584 (63.3) | 602 (64.3) | 917 (66.7) | 721 (65.9) | ||||||||